Published in Cell Death Dis on October 11, 2012
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci (2013) 1.26
Spermidine protects against α-synuclein neurotoxicity. Cell Cycle (2014) 1.02
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death Differ (2014) 1.00
The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev (2013) 0.95
Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes. Cell Death Dis (2013) 0.93
Spermidine promotes mating and fertilization efficiency in model organisms. Cell Cycle (2012) 0.89
Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int (2014) 0.85
Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice. Autophagy (2015) 0.81
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo. Cell Cycle (2015) 0.81
Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry. J Chromatogr A (2014) 0.80
Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE. J Biol Chem (2016) 0.77
Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition. PLoS One (2014) 0.76
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000Res (2016) 0.75
Spermidine on neurodegenerative diseases. Cell Cycle (2015) 0.75
Spermidine cures flies of senior moments. Nat Neurosci (2013) 0.75
Metabolomics reveal physiological changes in mayfly larvae (Neocloeon triangulifer) at ecological upper thermal limits. J Insect Physiol (2017) 0.75
Exploring Autophagy in Drosophila. Cells (2017) 0.75
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. NPJ Aging Mech Dis (2017) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
Extending healthy life span--from yeast to humans. Science (2010) 12.12
The genetics of ageing. Nature (2010) 12.08
Regulation of longevity and stress resistance by Sch9 in yeast. Science (2001) 5.93
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A (1995) 5.18
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
Biodemography of human ageing. Nature (2010) 4.26
Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev (2007) 3.18
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23
Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells. Toxicol Sci (2007) 1.87
Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis. Plant Physiol (2006) 1.84
Genome wide analysis of common and specific stress responses in adult drosophila melanogaster. BMC Genomics (2004) 1.82
Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction. J Biol Chem (2004) 1.62
Autophagy genes and ageing. Cell Death Differ (2008) 1.47
Polyamines in aging and disease. Aging (Albany NY) (2011) 1.36
The functional costs and benefits of dietary restriction in Drosophila. Aging Cell (2007) 1.33
Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp Gerontol (2009) 1.32
Carbon dioxide sensing modulates lifespan and physiology in Drosophila. PLoS Biol (2010) 1.28
Spermidine: a novel autophagy inducer and longevity elixir. Autophagy (2010) 1.23
Decrease in polyamines with aging and their ingestion from food and drink. J Biochem (2006) 1.15
Spermidine surprise for a long life. Nat Cell Biol (2009) 1.03
The propeptide of yeast cathepsin D inhibits programmed necrosis. Cell Death Dis (2011) 0.98
The effects of polyphenols on survival and locomotor activity in Drosophila melanogaster exposed to iron and paraquat. Neurochem Res (2009) 0.91
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice. Biochem J (2001) 0.88
Effect of rapamycin on lifespan in Drosophila. Geriatr Gerontol Int (2010) 0.86
Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging (Albany NY) (2011) 0.85
Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell (2011) 0.83
The role of calcium channel blockers and resveratrol in the prevention of paraquat-induced parkinsonism in Drosophila melanogaster: a locomotor analysis. Invert Neurosci (2011) 0.82
Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Molecular mechanisms of cisplatin resistance. Oncogene (2011) 5.20
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
Organelle-specific initiation of cell death pathways. Nat Cell Biol (2001) 5.03
Mitochondrial control of nuclear apoptosis. J Exp Med (1996) 5.01
Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol (2000) 4.89
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med (1995) 4.88
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science (1998) 4.84
Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol (1999) 4.76
Lysosomal membrane permeabilization in cell death. Oncogene (2008) 4.40
Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med (1995) 4.20
Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ (2007) 4.12
Bcl-2 inhibits the mitochondrial release of an apoptogenic protease. J Exp Med (1996) 4.00
The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol (2001) 3.66
Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis. Cytometry (1996) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Cell death modalities: classification and pathophysiological implications. Cell Death Differ (2007) 3.19
Mechanisms of cytochrome c release from mitochondria. Cell Death Differ (2006) 3.13
Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol (2001) 3.05
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene (2007) 2.85
Two distinct pathways leading to nuclear apoptosis. J Exp Med (2000) 2.84
Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ (2008) 2.84
The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med (1997) 2.83
Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med (1999) 2.79
Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene (2009) 2.74
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis (2010) 2.69
Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol (2001) 2.68
Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J (2000) 2.65
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J Exp Med (2000) 2.62
The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol (1998) 2.60
Calreticulin exposure is required for the immunogenicity of gamma-irradiation and UVC light-induced apoptosis. Cell Death Differ (2007) 2.58
Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun (2001) 2.56
The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J Exp Med (1998) 2.51
Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med (1996) 2.39
Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ (2010) 2.34
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ (2009) 2.29
NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem (2001) 2.22
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene (2010) 2.15
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2. J Exp Med (2001) 2.07
The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ (2008) 2.01
Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta (1998) 1.97
Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst (2000) 1.95
Molecular characteristics of immunogenic cancer cell death. Cell Death Differ (2007) 1.92
Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia. Oncogene (2011) 1.87
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ (1999) 1.84
Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene (2006) 1.83
Mitochondrial dysfunctions in circulating T lymphocytes from human immunodeficiency virus-1 carriers. Blood (1995) 1.83
Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett (2000) 1.82
Apoptosis. Mitochondria--the death signal integrators. Science (2000) 1.81
No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80
Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ (2006) 1.77
Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress. Oncogene (2010) 1.75
Metacaspases are caspases. Doubt no more. Cell Death Differ (2010) 1.74
Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ (2002) 1.72
GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization. Oncogene (2006) 1.65
Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic. Cell Death Differ (2002) 1.64
Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J Immunol (1996) 1.64
Molecular mechanisms of ATP secretion during immunogenic cell death. Cell Death Differ (2013) 1.64
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J (2001) 1.64
Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death Differ (2000) 1.64
Apoptosis-inducing factor (AIF): caspase-independent after all. Cell Death Differ (2004) 1.64
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ (2009) 1.62
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene (2000) 1.61
Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death. Oncogene (2008) 1.60
Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med (2000) 1.59
Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ (2009) 1.58
Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett (1996) 1.58
Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ (2010) 1.57
The mitochondrion in cell death control: certainties and incognita. Exp Cell Res (2000) 1.54
The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene (1997) 1.53
Mitochondria and programmed cell death: back to the future. FEBS Lett (1996) 1.52
New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level. EMBO J (2001) 1.52
Mechanisms of apoptosis induction by the HIV-1 envelope. Cell Death Differ (2005) 1.52
Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes. Immunol Lett (1998) 1.51
Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling. Cell Death Differ (2013) 1.49
Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett (1998) 1.49
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene (1998) 1.47
Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation. J Exp Med (2001) 1.47
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis. Oncogene (2000) 1.45
Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study. Oncogene (2011) 1.43
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal. Oncogene (2001) 1.42
Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ (2002) 1.42
BH3 mimetics activate multiple pro-autophagic pathways. Oncogene (2011) 1.41
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem (1998) 1.41
Targeting NF-kappaB in hematologic malignancies. Cell Death Differ (2006) 1.38
Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. Cell Death Differ (2000) 1.36
Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomembr (1997) 1.36
Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition pore. Exp Cell Res (1999) 1.33
Mammalian Bax triggers apoptotic changes in yeast. FEBS Lett (1998) 1.33
Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene (2001) 1.32