Published in BMC Genomics on September 30, 2004
The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors. Proc Natl Acad Sci U S A (2005) 3.09
Immunity and other defenses in pea aphids, Acyrthosiphon pisum. Genome Biol (2010) 2.09
The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Genome Biol (2005) 1.93
Full genome gene expression analysis of the heat stress response in Drosophila melanogaster. Cell Stress Chaperones (2005) 1.63
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance. Proc Natl Acad Sci U S A (2009) 1.45
Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics (2005) 1.39
The association among gene expression responses to nine abiotic stress treatments in Arabidopsis thaliana. Genetics (2006) 1.31
Transcriptional regulation of xenobiotic detoxification in Drosophila. Genes Dev (2011) 1.25
Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh fly. Proc Natl Acad Sci U S A (2010) 1.25
Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics (2006) 1.22
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech Dev (2009) 1.18
Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. PLoS One (2012) 1.14
Detoxification enzymes associated with insecticide resistance in laboratory strains of Anopheles arabiensis of different geographic origin. Parasit Vectors (2012) 1.11
Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis (2012) 1.10
Integrative analysis of large scale expression profiles reveals core transcriptional response and coordination between multiple cellular processes in a cyanobacterium. BMC Syst Biol (2010) 1.08
Genome-wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster. PLoS One (2012) 1.07
Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. PLoS One (2011) 1.02
Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Pestic Biochem Physiol (2010) 1.00
Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genet (2008) 1.00
Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol (2010) 0.99
Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene products. BMC Genomics (2008) 0.95
Gene expression changes governing extreme dehydration tolerance in an Antarctic insect. Proc Natl Acad Sci U S A (2012) 0.93
Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes. BMC Genomics (2012) 0.92
Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proc Natl Acad Sci U S A (2013) 0.91
Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Aging Cell (2013) 0.90
Gene-expression changes caused by inbreeding protect against inbreeding depression in Drosophila. Genetics (2012) 0.90
Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics (2012) 0.90
dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila. PLoS Genet (2012) 0.88
Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife (2014) 0.88
Expression of the Drosophila melanogaster GADD45 homolog (CG11086) affects egg asymmetric development that is mediated by the c-Jun N-terminal kinase pathway. Genetics (2007) 0.88
Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease. PLoS One (2014) 0.87
SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival. Fly (Austin) (2011) 0.86
Microarray methods in Drosophila neurobiology. Invert Neurosci (2005) 0.86
The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Genetics (2005) 0.85
Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PLoS One (2015) 0.84
Stress response in the ascidian Ciona intestinalis: transcriptional profiling of genes for the heat shock protein 70 chaperone system under heat stress and endoplasmic reticulum stress. Cell Stress Chaperones (2009) 0.83
Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. Neurobiol Dis (2011) 0.83
A transposable element insertion confers xenobiotic resistance in Drosophila. PLoS Genet (2014) 0.83
The role of calcium channel blockers and resveratrol in the prevention of paraquat-induced parkinsonism in Drosophila melanogaster: a locomotor analysis. Invert Neurosci (2011) 0.82
Expression of genes involved in energy mobilization and osmoprotectant synthesis during thermal and dehydration stress in the Antarctic midge, Belgica antarctica. J Comp Physiol B (2012) 0.80
Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism. PLoS One (2011) 0.79
Functional Characterization of Hypertrehalosemic Hormone Receptor in Relation to Hemolymph Trehalose and to Oxidative Stress in the Cockroach Blattella germanica. Front Endocrinol (Lausanne) (2012) 0.79
Heme Signaling Impacts Global Gene Expression, Immunity and Dengue Virus Infectivity in Aedes aegypti. PLoS One (2015) 0.78
Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster. PLoS One (2015) 0.78
Abiotic and biotic stressors causing equivalent mortality induce highly variable transcriptional responses in the soybean aphid. G3 (Bethesda) (2014) 0.78
A putative amino acid transporter of the solute carrier 6 family is upregulated by lithium and is required for resistance to lithium toxicity in Drosophila. Neuroscience (2009) 0.77
Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis. PLoS Genet (2014) 0.77
Are transcriptional responses to inbreeding a functional response to alleviate inbreeding depression? Fly (Austin) (2013) 0.76
Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis. J Mol Evol (2008) 0.76
Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS One (2016) 0.76
Ovarian gene expression is stable after exposure to trichloroethylene. Toxicol Lett (2007) 0.76
Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models. Front Genet (2012) 0.76
Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. Nat Commun (2017) 0.76
Genome-wide analysis on Chlamydomonas reinhardtii reveals the impact of hydrogen peroxide on protein stress responses and overlap with other stress transcriptomes. Plant J (2015) 0.75
Cloning and characterization of a novel Drosophila stress induced DNase. PLoS One (2014) 0.75
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress. Autophagy (2017) 0.75
Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. PLoS One (2013) 0.75
Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging. Biochim Biophys Acta (2016) 0.75
Interplay between RNA interference and heat shock response systems in Drosophila melanogaster. Open Biol (2016) 0.75
GAMMA-BASED CLUSTERING VIA ORDERED MEANS WITH APPLICATION TO GENE-EXPRESSION ANALYSIS. Ann Stat (2010) 0.75
In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. BMC Genet (2017) 0.75
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics (2003) 82.89
Creating the gene ontology resource: design and implementation. Genome Res (2001) 55.73
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev (1999) 13.24
Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell (2001) 9.63
The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem (1999) 8.97
Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc Natl Acad Sci U S A (2001) 5.45
Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 5.02
Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J (2001) 4.75
Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. EMBO J (2002) 3.58
A hierarchical unsupervised growing neural network for clustering gene expression patterns. Bioinformatics (2001) 3.56
The genomics of yeast responses to environmental stress and starvation. Funct Integr Genomics (2002) 3.37
Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene (2003) 3.32
The H2O2 stimulon in Saccharomyces cerevisiae. J Biol Chem (1998) 3.19
Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 2.94
Degradation of oxidized proteins by the 20S proteasome. Biochimie (2001) 2.93
Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science (2001) 2.40
Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc Natl Acad Sci U S A (2000) 2.39
Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med (1999) 2.32
The cellular response to p53: the decision between life and death. Oncogene (1999) 2.31
Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. J Biol Chem (2003) 2.02
Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci U S A (2000) 1.91
Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. J Biol Chem (1999) 1.83
Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem (1996) 1.75
Activity of ubiquitin-dependent pathway in response to oxidative stress. Ubiquitin-activating enzyme is transiently up-regulated. J Biol Chem (1997) 1.58
Iron metabolism in insects. Annu Rev Entomol (2002) 1.57
Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr Opin Genet Dev (2003) 1.41
Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc Natl Acad Sci U S A (1996) 1.36
Stress response in a juvenile hormone-deficient Drosophila melanogaster mutant apterous56f. Insect Mol Biol (2003) 1.34
Regulation of glutathione synthesis. Curr Top Cell Regul (2000) 1.31
Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. EMBO J (2002) 1.23
Thioredoxin peroxidases can foster cytoprotection or cell death in response to different stressors: over- and under-expression of thioredoxin peroxidase in Drosophila cells. Biochem J (2003) 1.16
Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells. Cell Mol Life Sci (2001) 1.12
Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. Free Radic Biol Med (2002) 0.94
Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation. Int J Biochem Cell Biol (2003) 0.93
A genetic variant of ACE increases cell survival: a new paradigm for biology and disease. Biochem Biophys Res Commun (2004) 0.93
Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster and identification of a novel behavioural mutant with a Shaker phenotype. Genome (1996) 0.91
Immunocytochemical analyses and targeted gene disruption of GTPBP1. Mol Cell Biol (2000) 0.87
Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Genesis (2002) 0.83
Paraquat selection identifies X-linked oxygen defense genes in Drosophila melanogaster. Genome (1993) 0.81
The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling. Cell Host Microbe (2009) 1.63
Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics (2006) 1.22
The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner. Mech Ageing Dev (2009) 1.14
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. J Neurosci (2007) 1.06
The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization. EMBO Rep (2007) 1.05
The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Genes Cells (2006) 1.03
Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. Free Radic Biol Med (2002) 0.94
Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1. PLoS Genet (2012) 0.90
dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila. PLoS Genet (2012) 0.88
Methylene blue rescues heart defects in a Drosophila model of Friedreich's ataxia. Hum Mol Genet (2013) 0.86
Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Genesis (2002) 0.83
Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster. Mech Ageing Dev (2010) 0.81
Characterization of the Drosophila myeloid leukemia factor. Genes Cells (2006) 0.80
Lack of miRNA Misregulation at Early Pathological Stages in Drosophila Neurodegenerative Disease Models. Front Genet (2012) 0.76
Methylene Blue Partially Rescues Heart Defects in a Drosophila Model of Huntington's Disease. J Huntingtons Dis (2015) 0.75