Regulation of voltage-dependent calcium channels by RGK proteins.

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Published in Biochim Biophys Acta on October 10, 2012

Authors

Tingting Yang1, Henry M Colecraft

Author Affiliations

1: Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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Calcium channels, stores, and oscillations. Annu Rev Cell Biol (1990) 6.12

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev (1994) 5.51

Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature (1999) 5.36

Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels. Neuron (1999) 5.32

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev (2005) 5.25

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature (1994) 4.34

Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80

The regulation of the calcium conductance of cardiac muscle by adrenaline. J Physiol (1977) 3.33

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat Cell Biol (1999) 3.18

Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron (2004) 3.05

Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature (2004) 3.04

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. J Biol Chem (1992) 3.03

The roles of the subunits in the function of the calcium channel. Science (1991) 2.97

Beta subunits of voltage-gated calcium channels. J Bioenerg Biomembr (2003) 2.96

CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65

Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science (1993) 2.57

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Nature (2004) 2.38

The ß subunit of voltage-gated Ca2+ channels. Physiol Rev (2010) 2.30

Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature (2001) 2.28

Roles of a membrane-localized beta subunit in the formation and targeting of functional L-type Ca2+ channels. J Biol Chem (1995) 2.19

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol (2005) 2.18

Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells. J Physiol (2002) 2.18

An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. Neuron (2007) 1.98

Gem: an induced, immediate early protein belonging to the Ras family. Science (1994) 1.94

Preferential closed-state inactivation of neuronal calcium channels. Neuron (1998) 1.92

Ca2+ channel regulation by a conserved beta subunit domain. Neuron (1994) 1.92

Creation of a genetic calcium channel blocker by targeted gem gene transfer in the heart. Circ Res (2004) 1.87

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Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit. J Biol Chem (2000) 1.85

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Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating. Biophys J (2003) 1.83

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