Human RAS superfamily proteins and related GTPases.

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59

Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system. PLoS One (2008) 3.09

A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89

It takes two to tango: regulation of G proteins by dimerization. Nat Rev Mol Cell Biol (2009) 2.34

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22

Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol (2010) 2.17

Inferring protein domain interactions from databases of interacting proteins. Genome Biol (2005) 1.97

Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat Cell Biol (2009) 1.87

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87

Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci U S A (2006) 1.77

Rare codons regulate KRas oncogenesis. Curr Biol (2012) 1.74

Evolution: Tracing the origins of centrioles, cilia, and flagella. J Cell Biol (2011) 1.69

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proc Natl Acad Sci U S A (2011) 1.57

TIP47 is a key effector for Rab9 localization. J Cell Biol (2006) 1.55

IFN-inducible GTPases in host cell defense. Cell Host Microbe (2012) 1.53

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol (2008) 1.53

The Ras protein superfamily: evolutionary tree and role of conserved amino acids. J Cell Biol (2012) 1.50

Evolution of the Ras-like small GTPases and their regulators. Small GTPases (2011) 1.48

Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44

Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi. Mol Biol Cell (2008) 1.43

The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling. Cell Signal (2007) 1.40

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. EMBO J (2006) 1.39

Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase. J Physiol (2010) 1.38

Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum. Mol Biol Cell (2006) 1.36

Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating. J Virol (2008) 1.36

DLC1: a significant GAP in the cancer genome. Genes Dev (2008) 1.36

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol (2007) 1.32

Functional specificity of ras isoforms: so similar but so different. Genes Cancer (2011) 1.30

Sculpting the endomembrane system in deep time: high resolution phylogenetics of Rab GTPases. J Cell Sci (2012) 1.25

An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Mol Biol Cell (2011) 1.22

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis. BMC Biol (2012) 1.21

The emerging role of the RAB25 small GTPase in cancer. Traffic (2009) 1.21

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. Proc Natl Acad Sci U S A (2011) 1.15

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management. Oncogene (2012) 1.15

Role of nucleotide binding in septin-septin interactions and septin localization in Saccharomyces cerevisiae. Mol Cell Biol (2008) 1.13

Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood (2007) 1.13

Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A (2012) 1.13

The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Cell Res (2012) 1.10

RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. Mol Cell Biol (2007) 1.07

Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A (2013) 1.07

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels. PLoS One (2012) 1.06

Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation. J Biol Chem (2009) 1.06

Genetic and biochemical alterations in non-small cell lung cancer. Biochem Res Int (2012) 1.05

RIN1 is a breast tumor suppressor gene. Cancer Res (2007) 1.05

Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. BMC Evol Biol (2007) 1.05

Guidelines for visualizing and annotating rule-based models. Mol Biosyst (2011) 1.05

TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci U S A (2012) 1.04

Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med (2012) 1.03

The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol (2010) 1.03

Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart. Circ Res (2010) 1.02

Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res (2013) 1.02

Intersecting pathways in cell biology. Sci Signal (2010) 1.01

Defining the boundaries: Rab GEFs and GAPs. Proc Natl Acad Sci U S A (2009) 1.01

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response. Nat Cell Biol (2013) 1.00

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet (2012) 1.00

RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR. J Cell Sci (2012) 0.98

Topological and functional properties of the small GTPases protein interaction network. PLoS One (2012) 0.98

Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am J Cancer Res (2011) 0.97

Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. J Biol Chem (2009) 0.97

A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J (2005) 0.97

The interaction properties of the human Rab GTPase family--comparative analysis reveals determinants of molecular binding selectivity. PLoS One (2012) 0.96

Evolution of the TOR pathway. J Mol Evol (2011) 0.95

A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress. Mol Cell Biol (2011) 0.94

Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. AAPS J (2010) 0.94

Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering. J Mol Biol (2009) 0.94

Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids. Cell Signal (2007) 0.94

Identification of a novel class of farnesylation targets by structure-based modeling of binding specificity. PLoS Comput Biol (2011) 0.93

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res (2010) 0.93

Regulation of voltage-dependent calcium channels by RGK proteins. Biochim Biophys Acta (2012) 0.92

GIMAP Proteins in T-Lymphocytes. J Signal Transduct (2010) 0.92

RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion. Cell Adh Migr (2011) 0.91

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1. J Biol Chem (2007) 0.91

NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation. Proc Natl Acad Sci U S A (2014) 0.91

Rit subfamily small GTPases: regulators in neuronal differentiation and survival. Cell Signal (2013) 0.90

Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms. Tissue Barriers (2013) 0.90

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J (2015) 0.90

The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue. Arthritis Res Ther (2009) 0.90

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation. Front Physiol (2014) 0.90

Targeted therapy for melanoma: a primer. Surg Oncol Clin N Am (2011) 0.89

Molecular genetics of testicular germ cell tumors. Am J Cancer Res (2012) 0.89

High genomic instability predicts survival in metastatic high-risk neuroblastoma. Neoplasia (2012) 0.89

The centaurin gamma-1 GTPase-like domain functions as an NTPase. Biochem J (2007) 0.89

Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. J Cell Biol (2013) 0.88

Down-regulation of c9orf86 in human breast cancer cells inhibits cell proliferation, invasion and tumor growth and correlates with survival of breast cancer patients. PLoS One (2013) 0.87

Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics (2011) 0.87

Structure of the disordered C terminus of Rab7 GTPase induced by binding to the Rab geranylgeranyl transferase catalytic complex reveals the mechanism of Rab prenylation. J Biol Chem (2009) 0.87

The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis. PLoS One (2009) 0.86

The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. Mol Cell Biol (2007) 0.86

Engineering proteins for custom inhibition of Ca(V) channels. Physiology (Bethesda) (2009) 0.86

Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase. PLoS One (2011) 0.85

Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Nucleic Acids Res (2011) 0.85

Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein. J Cell Biol (2007) 0.85

Targeting Cdc42 in cancer. Expert Opin Ther Targets (2013) 0.85

Large nucleotide-dependent conformational change in Rab28. FEBS Lett (2008) 0.85

Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia. Clin Cancer Res (2014) 0.85

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta (2011) 0.84

Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Biochim Biophys Acta (2007) 0.84

Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. J Biol Chem (2012) 0.83

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J (1982) 38.14

The GTPase superfamily: conserved structure and molecular mechanism. Nature (1991) 19.64

Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell (1993) 16.91

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88

Rho and Rac take center stage. Cell (2004) 10.64

Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (1994) 10.34

Proteins regulating Ras and its relatives. Nature (1993) 9.87

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev (2003) 9.58

The guanine nucleotide-binding switch in three dimensions. Science (2001) 9.34

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol (2003) 8.25

RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol (1988) 7.06

AN UNIDENTIFIED VIRUS WHICH CAUSES THE RAPID PRODUCTION OF TUMOURS IN MICE. Nature (1964) 6.96

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell (2003) 6.76

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell (1997) 6.55

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J (2000) 6.55

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell (1999) 6.42

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol (2003) 6.32

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature (1983) 5.90

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell (1991) 5.87

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol (1999) 5.84

A ras-related gene with transformation suppressor activity. Cell (1989) 5.81

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc Natl Acad Sci U S A (1987) 5.80

The Rab5 effector EEA1 is a core component of endosome docking. Nature (1999) 5.78

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science (1990) 5.76

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell (1996) 5.67

Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol (2003) 5.55

Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science (2003) 5.50

G protein pathways. Science (2002) 5.29

Multiple Ras functions can contribute to mammalian cell transformation. Cell (1995) 5.24

The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24

GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A (1987) 5.16

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell (2003) 5.05

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (1993) 5.02

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98

Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell (1990) 4.84

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts. Nature (1981) 4.72

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol (2002) 4.68

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (1993) 4.61

Evolution of the Rab family of small GTP-binding proteins. J Mol Biol (2001) 4.52

Two G protein oncogenes in human endocrine tumors. Science (1990) 4.46

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature (1983) 4.44

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol (2001) 4.42

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. Cell (1995) 4.39

Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A (1993) 4.30

Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30

Human-tumor-derived cell lines contain common and different transforming genes. Cell (1981) 4.29

Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell (2004) 4.21

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12

Transforming activity of human tumor DNAs. Proc Natl Acad Sci U S A (1981) 4.02

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J (1996) 3.99

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell (2004) 3.95

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell (1997) 3.93

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol (2003) 3.91

Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol (2002) 3.89

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell (1985) 3.73

Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun (1992) 3.66

The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Curr Biol (2001) 3.64

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell (1990) 3.56

Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. Nature (2003) 3.48

The Rab GTPase family. Genome Biol (2001) 3.37

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev (1995) 3.37

The exocyst is a Ral effector complex. Nat Cell Biol (2002) 3.33

DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol (2002) 3.32

Tubulin and FtsZ form a distinct family of GTPases. Nat Struct Biol (1998) 3.29

Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci (2004) 3.27

The complexity of Raf-1 regulation. Curr Opin Cell Biol (1997) 3.25

H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol (2000) 3.24

rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (1996) 3.18

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J Biol Chem (2000) 3.17

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell (1990) 3.16

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol (2000) 3.15

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol (1996) 3.13

Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature (2003) 3.08

Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. Science (2001) 3.02

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal (1999) 3.00

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99

Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J (2001) 2.97

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem (1996) 2.92

Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia. Nat Genet (2001) 2.86

Focus on pancreas cancer. Cancer Cell (2002) 2.82

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours. Nature (2002) 2.79

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat Cell Biol (2001) 2.78

The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J Cell Biol (2000) 2.72

Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem (1995) 2.69

Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol Chem (1995) 2.69

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem (2003) 2.66

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron (1998) 2.63

DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc Natl Acad Sci U S A (2002) 2.58

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Biochem Sci (2000) 2.58

Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science (1993) 2.57

Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Mol Cell Biol (1988) 2.57

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem (2002) 2.56

Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S A (2003) 2.52

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. Proc Natl Acad Sci U S A (1994) 2.50