Published in J Am Chem Soc on October 25, 2012
Direct stereospecific synthesis of unprotected N-H and N-Me aziridines from olefins. Science (2014) 1.48
Pd-catalyzed Semmler-Wolff reactions for the conversion of substituted cyclohexenone oximes to primary anilines. J Am Chem Soc (2013) 0.93
Dirhodium-catalyzed C-H arene amination using hydroxylamines. Science (2016) 0.88
Copper-catalyzed electrophilic amination of organolithiums mediated by recoverable siloxane transfer agents. Org Lett (2013) 0.81
One-pot anti-Markovnikov hydroamination of unactivated alkenes by hydrozirconation and amination. J Org Chem (2013) 0.78
Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters. Chemistry (2016) 0.75
Transition-Metal-Free ipso-Functionalization of Arylboronic Acids and Derivatives. Adv Synth Catal (2014) 0.75
Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as an Amide Source: Application in the Synthesis of an HDAC6 Inhibitor. Org Lett (2016) 0.75
Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds. Nat Chem (2016) 0.75
Density functionals with broad applicability in chemistry. Acc Chem Res (2008) 8.06
Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. J Phys Chem B (2009) 7.24
Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Phys Chem Chem Phys (2008) 5.98
Development of density functionals for thermochemical kinetics. J Chem Phys (2004) 1.44
Copper-catalyzed electrophilic amination of diorganozinc reagents. J Am Chem Soc (2004) 1.40
Direct stereospecific amination of alkyl and aryl pinacol boronates. J Am Chem Soc (2012) 1.34
Pd-catalyzed intermolecular C-H amination with alkylamines. J Am Chem Soc (2011) 1.19
Umpolung amination: nickel-catalyzed coupling reactions of N,N-dialkyl-N-chloroamines with diorganozinc reagents. J Am Chem Soc (2009) 1.18
ipso-nitration of arylboronic acids with chlorotrimethylsilane-nitrate salts. Org Lett (2004) 1.10
Synthesis of hindered anilines: copper-catalyzed electrophilic amination of aryl boronic esters. Angew Chem Int Ed Engl (2012) 1.01
Nitrosation of aryl and heteroaryltrifluoroborates with nitrosonium tetrafluoroborate. J Org Chem (2012) 0.97
A new entry of amination reagents for heteroaromatic C-H bonds: copper-catalyzed direct amination of azoles with chloroamines at room temperature. J Am Chem Soc (2010) 0.94
Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides. Org Lett (2012) 0.94
Transition-metal-free electrophilic amination of arylboroxines. Org Lett (2012) 0.93
Catalytic organometallic reactions of ammonia. Angew Chem Int Ed Engl (2011) 0.93
Direct amination of aryl halides with ammonia. Chem Soc Rev (2010) 0.88
Highly efficient synthesis of O-(2,4-dinitrophenyl)hydroxylamine. Application to the synthesis of substituted N-benzoyliminopyridinium ylides. J Org Chem (2003) 0.87
1,2-aryl and 1,2-hydride migration in transition metal complex catalyzed diazo decomposition: a novel approach to alpha-aryl-beta-enamino esters. Org Lett (2001) 0.86
Easy copper-catalyzed synthesis of primary aromatic amines by couplings aromatic boronic acids with aqueous ammonia at room temperature. Angew Chem Int Ed Engl (2009) 0.84
Expanding the [1,2]-aryl migration to the synthesis of substituted indoles. Angew Chem Int Ed Engl (2008) 0.84
Convenient and mild synthesis of nitroarenes by metal-free nitration of arylboronic acids. Chem Commun (Camb) (2011) 0.84
ipso-Nitration of arylboronic acids with bismuth nitrate and perdisulfate. Org Lett (2012) 0.82
Targeting QseC signaling and virulence for antibiotic development. Science (2008) 3.26
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab (2007) 2.41
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science (2007) 2.36
Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res (2006) 2.33
Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol (2007) 2.17
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91
Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors. Hypertension (2007) 1.83
Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J (2010) 1.82
Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. Cardiovasc Res (2006) 1.80
Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol (2005) 1.76
Proton-coupled electron transfer. Chem Rev (2012) 1.75
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
Reactivity and regioselectivity in 1,3-dipolar cycloadditions of azides to strained alkynes and alkenes: a computational study. J Am Chem Soc (2009) 1.60
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol (2007) 1.59
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest (2006) 1.59
Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci (2005) 1.59
Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. Am J Physiol Heart Circ Physiol (2007) 1.54
Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. J Pharmacol Exp Ther (2007) 1.53
Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ann Thorac Surg (2011) 1.52
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem (2005) 1.52
Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. J Pharmacol Exp Ther (2009) 1.51
Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J (2010) 1.48
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. J Cereb Blood Flow Metab (2007) 1.48
Steroid-producing cells regulate arterial tone of adrenal cortical arteries. Endocrinology (2007) 1.48
Direct stereospecific synthesis of unprotected N-H and N-Me aziridines from olefins. Science (2014) 1.48
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem (2005) 1.47
Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol (2002) 1.45
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol (2008) 1.44
Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis. Am J Physiol Cell Physiol (2008) 1.42
Inhibitors of cytochrome P450 4A suppress angiogenic responses. Am J Pathol (2005) 1.41
Global identification of O-GlcNAc-modified proteins. Anal Chem (2006) 1.40
20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther (2007) 1.40
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol (2006) 1.38
Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res (2007) 1.36
Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. Circ Res (2004) 1.36
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos (2007) 1.35
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension (2006) 1.34
Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol (2004) 1.33
Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. Prostaglandins Other Lipid Mediat (2002) 1.33
Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J (2007) 1.31
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem (2007) 1.30
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. Cancer Res (2004) 1.30
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. J Pharmacol Exp Ther (2008) 1.30
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. Hypertension (2003) 1.29
Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids. Br J Pharmacol (2005) 1.28
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. Cardiovasc Res (2005) 1.28
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J (2008) 1.28
Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation (2004) 1.27
Enantioselective synthesis of (E)-delta-stannyl homoallylic alcohols via aldehyde allylboration using alpha-stannylallylboranes generated by allene hydroboration followed by a highly diastereoselective 1,3-boratropic shift. J Am Chem Soc (2010) 1.27
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2006) 1.25
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J Biol Chem (2002) 1.25
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. J Mol Cell Cardiol (2007) 1.24
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol (2007) 1.24
Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle. Circ Res (2005) 1.22
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20
9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. J Pharmacol Exp Ther (2005) 1.19
Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine], a selective inhibitor of CYP4A. J Pharmacol Exp Ther (2005) 1.19
Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. J Mol Cell Cardiol (2004) 1.18
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. J Biol Chem (2008) 1.17
Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells. Antioxid Redox Signal (2005) 1.17
Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J (2005) 1.17
Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels. Microcirculation (2008) 1.16
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.15
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol (2004) 1.14
Tagging-via-substrate strategy for probing O-GlcNAc modified proteins. J Proteome Res (2005) 1.14
20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. J Pharmacol Exp Ther (2009) 1.13
Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. Kidney Int (2008) 1.13
Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation. Prostaglandins Other Lipid Mediat (2006) 1.12
Selective enrichment of thiophosphorylated polypeptides as a tool for the analysis of protein phosphorylation. Mol Cell Proteomics (2003) 1.11
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. Hypertension (2011) 1.10
Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation. Circ Res (2003) 1.10
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. Am J Physiol Renal Physiol (2009) 1.09
Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes. Free Radic Biol Med (2006) 1.08
Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.08
Thermodynamic control of 1,3-boratropic shifts of α- and γ-stannyl-substituted allylboranes: hyperconjugation outweighs steric effects. Org Lett (2011) 1.08
Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A (2013) 1.08
Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. Am J Physiol Regul Integr Comp Physiol (2007) 1.08
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer (2007) 1.07
Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol (2008) 1.07
Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc (2009) 1.06
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells. Am J Physiol Heart Circ Physiol (2009) 1.05
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex. Am J Physiol Heart Circ Physiol (2008) 1.05
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension (2010) 1.05
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. Am J Physiol Renal Physiol (2009) 1.05
The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents. Exp Physiol (2007) 1.04
Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. Prostaglandins Other Lipid Mediat (2011) 1.04
Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog. Am J Physiol Heart Circ Physiol (2009) 1.04
Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol (2010) 1.03
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. J Lipid Res (2012) 1.03
Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice. Am J Physiol Heart Circ Physiol (2008) 1.03
Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry. Clin Chem (2004) 1.03
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo. J Pharmacol Exp Ther (2008) 1.03
11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells. Prostaglandins Other Lipid Mediat (2006) 1.03
Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin Sci (Lond) (2010) 1.03
Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes. Angew Chem Int Ed Engl (2008) 1.03
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. Hypertension (2005) 1.03