Global identification of O-GlcNAc-modified proteins.

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl (2009) 8.15

The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66

Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A (2006) 1.85

Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nat Chem Biol (2008) 1.60

Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury. Circ Res (2008) 1.50

Metabolic glycoengineering: sialic acid and beyond. Glycobiology (2009) 1.45

O-GlcNAc signaling in the cardiovascular system. Circ Res (2010) 1.43

dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. BMC Bioinformatics (2011) 1.36

Chemical approaches to perturb, profile, and perceive glycans. Acc Chem Res (2009) 1.33

The chemical neurobiology of carbohydrates. Chem Rev (2008) 1.33

Quantitative proteomic analysis of histone modifications. Chem Rev (2015) 1.32

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1. Proc Natl Acad Sci U S A (2011) 1.21

Protein O-linked β-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol (2011) 1.14

Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics (2013) 1.12

Cancer metabolism and elevated O-GlcNAc in oncogenic signaling. J Biol Chem (2014) 1.11

Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc Natl Acad Sci U S A (2010) 1.08

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry. J Proteome Res (2013) 1.02

Glycomic analysis: an array of technologies. ACS Chem Biol (2009) 1.00

Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis. Cell Stress Chaperones (2013) 0.98

The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease. Am J Physiol Heart Circ Physiol (2012) 0.97

Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Mol Biol (2011) 0.94

Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Protein Sci (2011) 0.93

A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Bioorg Med Chem Lett (2007) 0.91

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification. J Am Chem Soc (2014) 0.90

Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination. Mol Cell Proteomics (2013) 0.90

Characterization and identification of protein O-GlcNAcylation sites with substrate specificity. BMC Bioinformatics (2014) 0.88

Multiple proteins with essential mitochondrial functions have glycosylated isoforms. Mitochondrion (2012) 0.86

Hallmarks of glycosylation in cancer. Oncotarget (2016) 0.86

Aberrant O-GlcNAcylated Proteins: New Perspectives in Breast and Colorectal Cancer. Front Endocrinol (Lausanne) (2014) 0.86

Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods. PLoS One (2013) 0.85

O-GlcNAc signaling in cancer metabolism and epigenetics. Cancer Lett (2014) 0.84

Metabolic labeling of Caenorhabditis elegans primary embryonic cells with azido-sugars as a tool for glycoprotein discovery. PLoS One (2012) 0.84

Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc (2014) 0.84

Chemical approaches to study O-GlcNAcylation. Chem Soc Rev (2012) 0.84

Recent advances in chemical proteomics: exploring the post-translational proteome. J Chem Biol (2008) 0.84

Regulation of cancer metabolism by O-GlcNAcylation. Glycoconj J (2013) 0.82

A two-layered machine learning method to identify protein O-GlcNAcylation sites with O-GlcNAc transferase substrate motifs. BMC Bioinformatics (2015) 0.82

A bird's-eye view of post-translational modifications in the spliceosome and their roles in spliceosome dynamics. Mol Biosyst (2010) 0.78

Chemical Glycoproteomics. Chem Rev (2016) 0.78

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. Mol Cancer Res (2015) 0.78

Recent advances in the MS analysis of glycoproteins: Capillary and microfluidic workflows. Electrophoresis (2010) 0.77

Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells. Biomed Res Int (2015) 0.76

Incorporation of unnatural sugars for the identification of glycoproteins. Methods Mol Biol (2013) 0.76

The Role of the O-GlcNAc Modification in Regulating Eukaryotic Gene Expression. Curr Signal Transduct Ther (2010) 0.76

Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells. Glycobiology (2014) 0.75

O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans. Sci Rep (2017) 0.75

Illuminating the wall: using click chemistry to image pectins in Arabidopsis cell walls. Plant Signal Behav (2012) 0.75

Exercise training increases protein O-GlcNAcylation in rat skeletal muscle. Physiol Rep (2016) 0.75

Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function and survival in HeLa cells. J Biol Chem (2017) 0.75

Analysis of Protein O-GlcNAcylation by Mass Spectrometry. Curr Protoc Protein Sci (2017) 0.75

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38

Acetylation is indispensable for p53 activation. Cell (2008) 5.70

Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26

RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell (2006) 5.08

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96

Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36

Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J Biol Chem (2003) 3.90

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science (2003) 3.59

JMJD6 is a histone arginine demethylase. Science (2007) 3.48

Targeting QseC signaling and virulence for antibiotic development. Science (2008) 3.26

Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09

Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99

CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature (2010) 2.88

Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol (2010) 2.87

The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83

Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res (2007) 2.76

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci U S A (2004) 2.74

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell (2012) 2.46

Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab (2007) 2.41

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science (2007) 2.36

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res (2006) 2.33

Integrated approach for manual evaluation of peptides identified by searching protein sequence databases with tandem mass spectra. J Proteome Res (2005) 2.27

Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol (2007) 2.17

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell (2013) 2.17

Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol (2006) 2.04

A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01

Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. J Cell Biol (2003) 1.91

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A (2006) 1.90

Prevalence of prehypertension and hypertension in a Chinese rural area from 1991 to 2007. Hypertens Res (2010) 1.90

2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers. Mol Cell Proteomics (2002) 1.85

Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors. Hypertension (2007) 1.83

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice. FASEB J (2010) 1.82

Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81

Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries. Cardiovasc Res (2006) 1.80

Proteomic analysis of integral plasma membrane proteins. Anal Chem (2004) 1.78

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol (2005) 1.76

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell (2006) 1.67

Proteomics of human breast ductal carcinoma in situ. Cancer Res (2002) 1.62

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest (2006) 1.59

TAO kinases mediate activation of p38 in response to DNA damage. EMBO J (2007) 1.59

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. Am J Physiol Heart Circ Physiol (2007) 1.59

Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci (2005) 1.59

Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction. Proc Natl Acad Sci U S A (2005) 1.59

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J (2007) 1.55

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Mol Cell Proteomics (2012) 1.54

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia. Am J Physiol Heart Circ Physiol (2007) 1.54

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. J Pharmacol Exp Ther (2007) 1.53

Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ann Thorac Surg (2011) 1.52

Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem (2005) 1.52

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. J Pharmacol Exp Ther (2009) 1.51

Evaluation of ethanol-fixed, paraffin-embedded tissues for proteomic applications. Proteomics (2003) 1.50

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice. FASEB J (2010) 1.48

Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. J Cereb Blood Flow Metab (2007) 1.48

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48

Direct stereospecific synthesis of unprotected N-H and N-Me aziridines from olefins. Science (2014) 1.48

Steroid-producing cells regulate arterial tone of adrenal cortical arteries. Endocrinology (2007) 1.48

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem (2005) 1.47

PTMap--a sequence alignment software for unrestricted, accurate, and full-spectrum identification of post-translational modification sites. Proc Natl Acad Sci U S A (2009) 1.46

Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol (2002) 1.45

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res (2004) 1.44

Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol (2008) 1.44

Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem (2008) 1.44

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis. Am J Physiol Cell Physiol (2008) 1.42

Impact of transradial coronary procedures on radial artery function. Angiology (2013) 1.41

Inhibitors of cytochrome P450 4A suppress angiogenic responses. Am J Pathol (2005) 1.41

Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol (2010) 1.40

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40

20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells. J Pharmacol Exp Ther (2007) 1.40

Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex. Nucleic Acids Res (2008) 1.39

Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.39

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One (2011) 1.38

Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury. Am J Physiol Heart Circ Physiol (2006) 1.38

Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. Circ Res (2004) 1.36

Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors. Circ Res (2007) 1.36

Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos (2007) 1.35

Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension (2006) 1.34

Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways. J Gen Physiol (2004) 1.33

Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33

A clean, more efficient method for in-solution digestion of protein mixtures without detergent or urea. J Proteome Res (2006) 1.33

Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. Prostaglandins Other Lipid Mediat (2002) 1.33

Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J (2007) 1.31

Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics (2002) 1.31

Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem (2007) 1.30

2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. Cancer Res (2004) 1.30

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. J Pharmacol Exp Ther (2008) 1.30

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci (2013) 1.30