Published in Environ Health Perspect on October 19, 2012
The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease. J Bone Miner Res (2014) 0.89
Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice. Environ Health Perspect (2015) 0.88
Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology (2015) 0.87
Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/β-CATENIN SIGNALING PATHWAY. J Biol Chem (2015) 0.86
Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones. J Biomed Opt (2013) 0.83
Association between urinary lead and bone health in a general population from Taiwan. J Expo Sci Environ Epidemiol (2015) 0.80
Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix. Bone (2014) 0.80
Bone lead (Pb) content at the tibia is associated with thinner distal tibia cortices and lower volumetric bone density in postmenopausal women. Bone (2015) 0.80
Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue. Biomed Opt Express (2015) 0.80
Elevated Lifetime Lead Exposure Impedes Osteoclast Activity and Produces an Increase in Bone Mass in Adolescent Mice. Toxicol Sci (2015) 0.78
Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol (2015) 0.77
Environmental Factors Impacting Bone-Relevant Chemokines. Front Endocrinol (Lausanne) (2017) 0.75
A One-Two Punch to Bone: Assessing the Combined Impact of Lead and a High-Fat Diet. Environ Health Perspect (2015) 0.75
Inhibition of beta-catenin signaling by Pb leads to incomplete fracture healing. J Orthop Res (2014) 0.75
Allogeneic and Autogenous Bone Grafts Are Affected by Historical Donor Environmental Exposure. Clin Orthop Relat Res (2016) 0.75
Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells. Toxicol Sci (2016) 0.75
More fat, less bone? Flame retardant may deliver a one-two punch. Environ Health Perspect (2014) 0.75
Reduced bone and body mass in young male rats exposed to lead. Biomed Res Int (2014) 0.75
Association of fractures with the incidence of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener (2017) 0.75
Inhibition of adipogenesis by Wnt signaling. Science (2000) 9.72
National estimates of blood lead levels: United States, 1976-1980: association with selected demographic and socioeconomic factors. N Engl J Med (1982) 5.64
Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem (2005) 5.33
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res (2008) 4.82
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res (2009) 4.40
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res (2011) 3.25
Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem (2006) 3.10
Playing with bone and fat. J Cell Biochem (2006) 2.94
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood (2009) 2.61
Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol (2004) 2.52
Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol (2002) 2.28
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev (2005) 1.88
Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) Am J Hum Genet (1997) 1.75
Lead toxicity: current concerns. Environ Health Perspect (1993) 1.61
LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res (2004) 1.45
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem (2008) 1.41
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int (2008) 1.35
Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol (2004) 1.28
Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro. Bone (2002) 1.18
Osteopenia induced by long-term, low- and high-level exposure of the adult rat to lead. Miner Electrolyte Metab (1997) 1.16
The effect of Pb(2+) on the structure and hydroxyapatite binding properties of osteocalcin. Biochim Biophys Acta (2001) 1.14
Effect of lead on bone development and bone mass: a morphometric, densitometric, and histomorphometric study in growing rats. Calcif Tissue Int (1997) 1.12
Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect (2005) 1.11
Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Mol Cell Biol (2007) 1.09
A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling. J Bone Miner Res (2010) 1.02
Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. J Biomed Opt (2011) 1.02
The association between blood lead levels and osteoporosis among adults--results from the third national health and nutrition examination survey (NHANES III). Environ Health Perspect (2007) 1.01
Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress. Toxicol Sci (2010) 1.00
Regulation of osteoblastic gene expression by lead. Endocrinology (1993) 1.00
Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures. J Bone Miner Res (2008) 0.95
Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res (2007) 0.91
Effects of acute and chronic oval exposure of lead on blood pressure and bone mineral density in rats. J Inorg Biochem (2005) 0.89
The effect of lead on bone mineral properties from female adult C57/BL6 mice. Bone (2010) 0.88
PPARgamma1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion. J Cell Biochem (2004) 0.88
Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8 cells. Toxicol Appl Pharmacol (1992) 0.86
Osteon morphometry in females with femoral neck fractures. Clin Orthop Relat Res (1992) 0.83
Targeting the Wnt signaling pathway to augment bone formation. Curr Osteoporos Rep (2008) 0.82
Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med (2003) 16.73
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest (2002) 3.29
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis (2002) 2.83
Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect (2008) 2.81
The role of Axin2 in calvarial morphogenesis and craniosynostosis. Development (2005) 2.63
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (2007) 2.01
COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res (2002) 1.84
Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur J Neurosci (2003) 1.77
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci (2008) 1.67
Direct characterization and removal of interfering absorption trends in two-layer turbid media. J Opt Soc Am A Opt Image Sci Vis (2005) 1.67
ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res (2003) 1.66
High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther (2011) 1.62
The outdoor air pollution and brain health workshop. Neurotoxicology (2012) 1.60
Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem (2005) 1.56
Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. Gene (2012) 1.56
Two-detector Corrected Near Infrared Spectroscopy (C-NIRS) detects hemodynamic activation responses more robustly than single-detector NIRS. Neuroimage (2011) 1.51
Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol (2002) 1.51
Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement. Environ Health Perspect (2016) 1.50
Brain specificity of diffuse optical imaging: improvements from superficial signal regression and tomography. Front Neuroenergetics (2010) 1.48
Impaired neuropsychological functioning in lead-exposed children. Dev Neuropsychol (2004) 1.41
Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype. Neurotoxicology (2002) 1.40
Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res (2005) 1.39
Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A (2002) 1.33
Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum (2008) 1.31
Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res (2009) 1.31
NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res (2003) 1.30
Retracted Sustained exposure to the widely used herbicide atrazine: altered function and loss of neurons in brain monoamine systems. Environ Health Perspect (2005) 1.30
Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. J Cell Sci (2009) 1.29
Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. Development (2012) 1.28
Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. J Orthop Res (2008) 1.28
Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci (2005) 1.25
Method for automated background subtraction from Raman spectra containing known contaminants. Analyst (2009) 1.24
Chemical concentration measurement in blood serum and urine samples using liquid-core optical fiber Raman spectroscopy. Appl Opt (2007) 1.22
Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem (2003) 1.20
Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta. J Cell Biochem (2005) 1.18
The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod Toxicol (2007) 1.18
Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study. Neurotoxicology (2011) 1.18
Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Biol Psychiatry (2007) 1.18
In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res (2002) 1.17
Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. J Biol Chem (2006) 1.17
Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem (2007) 1.14
A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res (2002) 1.13
Maternal PUFA status but not prenatal methylmercury exposure is associated with children's language functions at age five years in the Seychelles. J Nutr (2012) 1.12
Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med (2011) 1.12
Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect (2005) 1.11
PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. J Bone Miner Res (2013) 1.11
Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum (2006) 1.10
PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Exp Cell Res (2004) 1.09
Orthopedic uses of teriparatide. Curr Osteoporos Rep (2010) 1.09
Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res (2004) 1.08
A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem (2002) 1.06
Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res (2007) 1.05
Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res (2002) 1.05
Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. J Bone Miner Res (2005) 1.04
Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. J Biomed Opt (2011) 1.02
Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Exp Cell Res (2005) 1.01
Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. J Biomed Mater Res A (2010) 1.01
Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res (2010) 1.00
Erythropoietin accelerates functional recovery after peripheral nerve injury. J Bone Joint Surg Am (2008) 0.99
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Exp Cell Res (2009) 0.99
Beta-catenin, cartilage, and osteoarthritis. Ann N Y Acad Sci (2010) 0.99
In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett (2014) 0.99
Determination of uncertainty in parameters extracted from single spectroscopic measurements. J Biomed Opt (2007) 0.98
ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Exp Cell Res (2003) 0.97
Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates. J Neurochem (2003) 0.97
Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice. Environ Health Perspect (2014) 0.97
The association between environmental lead exposure and bone density in children. Environ Health Perspect (2004) 0.96
Integrated Raman- and angular-scattering microscopy. Opt Lett (2008) 0.96
Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology (2003) 0.95
A fetal risk factor for Parkinson's disease. Dev Neurosci (2004) 0.95
Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis. Arthritis Rheum (2010) 0.95
CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol (2004) 0.95
5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem (2004) 0.94
Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J Orthop Res (2002) 0.94
Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res (2011) 0.94
Identification of different bacterial species in biofilms using confocal Raman microscopy. J Biomed Opt (2011) 0.94
Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. Cell Cycle (2009) 0.94
Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene. J Cell Physiol (2012) 0.93
Validation of an integrated Raman- and angular-scattering microscopy system on heterogeneous bead mixtures and single human immune cells. Appl Opt (2009) 0.93
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem (2005) 0.93
Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation. Biochem Biophys Res Commun (2005) 0.93
Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res (2008) 0.93
Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis Rheum (2012) 0.92