Published in Exp Physiol on October 26, 2012
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol (2013) 0.94
Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. J Biol Chem (2013) 0.87
Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus. J Neurochem (2014) 0.84
HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats. Am J Physiol Regul Integr Comp Physiol (2014) 0.82
Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats. J Neurochem (2013) 0.82
GPER-novel membrane oestrogen receptor. Clin Sci (Lond) (2016) 0.78
G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. J Neurochem (2015) 0.77
Evidence for role of acid-sensing ion channels in nucleus ambiguus neurons: essential differences in anesthetized versus awake rats. J Comp Physiol B (2014) 0.75
Activation of GPER ameliorates experimental pulmonary hypertension in male rats. Eur J Pharm Sci (2016) 0.75
Sex and the heart: timing is everything. Exp Physiol (2013) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Neuronal calcium signaling. Neuron (1998) 7.03
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol (2011) 2.33
Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology (2007) 2.29
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol (2007) 2.20
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes. Biochim Biophys Acta (1984) 1.78
Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons. Mol Endocrinol (2009) 1.72
Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Am J Physiol Heart Circ Physiol (2009) 1.59
Use of voltage-sensitive dyes and optical recordings in the central nervous system. Prog Neurobiol (1995) 1.58
Sex-related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation (1996) 1.50
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol (2011) 1.42
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem (2009) 1.42
Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol (2003) 1.38
Gender, sex hormones and autonomic nervous control of the cardiovascular system. Cardiovasc Res (2002) 1.38
Advances in Parasympathetic Control of Heart Rate and Cardiac Function. News Physiol Sci (1999) 1.37
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol (2010) 1.29
Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. J Comp Neurol (2005) 1.28
GPR30/GPER1: searching for a role in estrogen physiology. Trends Endocrinol Metab (2009) 1.24
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation. Neurosci Lett (2008) 1.19
Autonomic and cardiovascular reflex responses to central estrogen injection in ovariectomized female rats. Brain Res (2000) 1.19
Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780. Pharmacology (2010) 1.17
Firing properties of identified parasympathetic cardiac neurons in nucleus ambiguus. Am J Physiol (1996) 1.16
Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus. J Neurophysiol (2006) 1.13
Role of oestrogen in the central regulation of autonomic function. Clin Exp Pharmacol Physiol (2007) 1.11
Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res (2009) 1.11
Estrogen enhancement of baroreflex sensitivity is centrally mediated. Am J Physiol (1999) 1.10
Evidence of a role of endogenous estrogen in the modulation of autonomic nervous system. Am J Cardiol (2000) 1.09
NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. Biochem J (2009) 1.07
Oestrogen receptors in the central nervous system and evidence for their role in the control of cardiovascular function. J Chem Neuroanat (2009) 1.06
Medullary and intrathecal injections of 17beta-estradiol in male rats. Brain Res (2000) 1.04
Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. Am J Physiol Endocrinol Metab (2011) 1.02
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J Biol Chem (2010) 1.02
Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons. Neuroscience (2007) 1.00
Centrally mediated effect of 17beta-estradiol on parasympathetic tone in male rats. Am J Physiol (1999) 0.97
Cardiovascular protection by oestrogen is partly mediated through modulation of autonomic nervous function. Cardiovasc Res (1995) 0.94
17beta-estradiol modulates baroreflex sensitivity and autonomic tone of female rats. J Auton Nerv Syst (2000) 0.92
Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain (2012) 0.91
A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster. J Endocrinol (2008) 0.91
G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium. Am J Physiol Cell Physiol (2011) 0.90
17Beta-estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats. Am J Physiol Cell Physiol (2009) 0.88
Circadian and estrous cycle-dependent variations in blood pressure and heart rate in female rats. Am J Physiol (1994) 0.86
G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium. Endocrinology (2011) 0.86
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons. J Neurochem (2012) 0.86
Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia. Am J Physiol Heart Circ Physiol (2010) 0.85
Modulation of heart rate variability by estrogen in young women undergoing induction of ovulation. Eur J Appl Physiol (2008) 0.84
Voltage-gated currents in identified parasympathetic cardiac neurons in the nucleus ambiguus. Brain Res (1996) 0.79
The effect of estrogen replacement therapy on cardiac autonomic regulation. Maturitas (2000) 0.78
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension (2011) 3.26
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol (2008) 3.20
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res (2007) 2.71
In vivo effects of a GPR30 antagonist. Nat Chem Biol (2009) 2.39
Pursuing the leadlikeness concept in pharmaceutical research. Curr Opin Chem Biol (2004) 2.36
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol (2007) 2.20
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Quantifying the relationships among drug classes. J Chem Inf Model (2008) 1.92
Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology (2007) 1.90
BDDCS applied to over 900 drugs. AAPS J (2011) 1.68
Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells. J Biol Chem (2011) 1.67
An automated PLS search for biologically relevant QSAR descriptors. J Comput Aided Mol Des (2005) 1.66
The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP. Biochem J (2013) 1.62
GPR30: A G protein-coupled receptor for estrogen. Mol Cell Endocrinol (2007) 1.59
Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol (2011) 1.56
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol (2014) 1.51
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm Res (2008) 1.46
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol (2011) 1.42
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol (2007) 1.37
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol (2005) 1.37
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res (2010) 1.36
The ins and outs of GPR30: a transmembrane estrogen receptor. J Steroid Biochem Mol Biol (2008) 1.36
ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol (2006) 1.33
Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection? J Comput Aided Mol Des (2008) 1.32
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
Novel chemical space exploration via natural products. J Med Chem (2009) 1.27
Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals. Cell Calcium (2010) 1.26
GPR30: a novel therapeutic target in estrogen-related disease. Trends Pharmacol Sci (2008) 1.25
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. J Biomol Screen (2005) 1.22
Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem (2011) 1.20
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem (2005) 1.19
KiSS-1 expression and metastin-like immunoreactivity in the rat brain. J Comp Neurol (2005) 1.18
ChemProt-2.0: visual navigation in a disease chemical biology database. Nucleic Acids Res (2012) 1.17
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields. J Med Chem (2011) 1.17
Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem (2011) 1.17
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. J Med Chem (2010) 1.16
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem (2010) 1.16
In vitro differentiation of human mesenchymal stem cells to epithelial lineage. J Cell Mol Med (2007) 1.16
Ribavirin reveals a lethal threshold of allowable mutation frequency for Hantaan virus. J Virol (2007) 1.15
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Assay Drug Dev Technol (2008) 1.14
Rapid evaluation of synthetic and molecular complexity for in silico chemistry. J Chem Inf Model (2005) 1.13
Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol (2009) 1.11
Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res (2009) 1.11
Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol (2010) 1.09
Cardiovascular effects of adrenocorticotropin microinjections into the rostral ventrolateral medullary pressor area of the rat. Brain Res (2006) 1.09
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nat Protoc (2006) 1.07
NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. Biochem J (2009) 1.07
The CARLSBAD database: a confederated database of chemical bioactivities. Database (Oxford) (2013) 1.05
ChemProt: a disease chemical biology database. Nucleic Acids Res (2010) 1.03
Scaffold topologies. 2. Analysis of chemical databases. J Chem Inf Model (2008) 1.02
Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate. Biochem J (2009) 1.02
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J Biol Chem (2010) 1.02
Exemestane's 17-hydroxylated metabolite exerts biological effects as an androgen. Mol Cancer Ther (2007) 1.01
Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats. Gastroenterology (2009) 1.00
Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells. Endocrinology (2008) 1.00
The hypothalamic arcuate nucleus: a new site of cardiovascular action of angiotensin-(1-12) and angiotensin II. Am J Physiol Heart Circ Physiol (2010) 0.99
Potential importance of error catastrophe to the development of antiviral strategies for hantaviruses. Virus Res (2005) 0.98
Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells. Toxicol Appl Pharmacol (2007) 0.98
Depressor and bradycardic responses to microinjections of endomorphin-2 into the NTS are mediated via ionotropic glutamate receptors. Am J Physiol Regul Integr Comp Physiol (2004) 0.98
Emerging trends in the discovery of natural product antibacterials. Curr Opin Pharmacol (2013) 0.97
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium (2011) 0.97
Virtual screening applications: a study of ligand-based methods and different structure representations in four different scenarios. J Comput Aided Mol Des (2007) 0.95
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent. J Biomol Screen (2008) 0.95
Strategies for compound selection. Curr Drug Discov Technol (2004) 0.95
High-throughput flow cytometry for drug discovery. Expert Opin Drug Discov (2007) 0.95
Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol (2014) 0.94
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Org Biomol Chem (2010) 0.94
Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol (2013) 0.94
iPHACE: integrative navigation in pharmacological space. Bioinformatics (2010) 0.93
Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates. J Am Chem Soc (2006) 0.93
Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol (2008) 0.93
Scaffold topologies. 1. Exhaustive enumeration up to eight rings. J Chem Inf Model (2008) 0.93
A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol (2012) 0.92
Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev (2011) 0.92
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry A (2009) 0.92
Domain assembly of NAADP-gated two-pore channels. Biochem J (2012) 0.92
Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain (2012) 0.91
Carbon nanopipettes characterize calcium release pathways in breast cancer cells. Nanotechnology (2008) 0.91
Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 0.91
G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium. Am J Physiol Cell Physiol (2011) 0.90