Published in J Steroid Biochem Mol Biol on July 14, 2011
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus. Exp Physiol (2012) 1.51
Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol (2014) 1.23
MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells. Breast Cancer Res (2012) 1.00
GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Horm Cancer (2014) 0.99
Loss of GPER identifies new targets for therapy among a subgroup of ERα-positive endometrial cancer patients with poor outcome. Br J Cancer (2012) 0.96
Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol (2013) 0.94
Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia (2012) 0.92
The G-protein-coupled estrogen receptor agonist G-1 suppresses proliferation of ovarian cancer cells by blocking tubulin polymerization. Cell Death Dis (2013) 0.91
GPER Function in Breast Cancer: An Overview. Front Endocrinol (Lausanne) (2014) 0.90
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstet Gynecol Int (2013) 0.88
International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacol Rev (2015) 0.87
Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus. PLoS One (2012) 0.87
Molecular mechanisms underlying the memory-enhancing effects of estradiol. Horm Behav (2015) 0.87
G protein-coupled estrogen receptor protects from atherosclerosis. Sci Rep (2014) 0.86
G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res (2014) 0.85
GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism. Methods Mol Biol (2016) 0.84
Emerging roles of GPER in diabetes and atherosclerosis. Trends Endocrinol Metab (2015) 0.84
A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J Cell Biol (2015) 0.83
Stimulation of GPR30 increases release of EMMPRIN-containing microvesicles in human uterine epithelial cells. J Clin Endocrinol Metab (2012) 0.83
What have we learned about GPER function in physiology and disease from knockout mice? J Steroid Biochem Mol Biol (2015) 0.81
Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. PLoS One (2012) 0.81
Contributions of academic laboratories to the discovery and development of chemical biology tools. J Med Chem (2013) 0.81
Exogenous hormonal regulation in breast cancer cells by phytoestrogens and endocrine disruptors. Curr Med Chem (2014) 0.81
Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells. Front Endocrinol (Lausanne) (2015) 0.81
GPER expressed on microglia mediates the anti-inflammatory effect of estradiol in ischemic stroke. Brain Behav (2016) 0.80
A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models. Dis Model Mech (2015) 0.80
Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30. Am J Physiol Renal Physiol (2014) 0.79
The effects of (-)-epicatechin on endothelial cells involve the G protein-coupled estrogen receptor (GPER). Pharmacol Res (2015) 0.78
GPER-novel membrane oestrogen receptor. Clin Sci (Lond) (2016) 0.78
Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain. Pain (2014) 0.78
Obligatory role for GPER in cardiovascular aging and disease. Sci Signal (2016) 0.77
Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17β-estradiol. BMC Cancer (2014) 0.77
G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. J Neurochem (2015) 0.77
Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior. Front Endocrinol (Lausanne) (2015) 0.77
Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat. J Gerontol A Biol Sci Med Sci (2016) 0.77
G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity. J Endocrinol (2015) 0.76
The G protein-coupled estrogen receptor 1 (GPER-1) contributes to the proliferation and survival of mantle cell lymphoma cells. Haematologica (2015) 0.76
Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer (2015) 0.76
Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation. J Cardiovasc Pharmacol (2013) 0.76
GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells. Mol Cell Endocrinol (2015) 0.76
GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding. Mol Cancer Res (2014) 0.76
Acting on Hormone Receptors with Minimal Side Effect on Cell Proliferation: A Timely Challenge Illustrated with GLP-1R and GPER. Front Endocrinol (Lausanne) (2013) 0.76
Cytoplasmic kinases downstream of GPR30 suppress gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone secretion from bovine anterior pituitary cells. J Reprod Dev (2015) 0.75
Dissecting rapid estrogen signaling with conjugates. Steroids (2012) 0.75
Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats. PLoS One (2015) 0.75
Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands. AAPS J (2015) 0.75
G Protein-Coupled Estrogen Receptor (GPER) Agonist Dual Binding Mode Analyses toward Understanding of its Activation Mechanism: A Comparative Homology Modeling Approach. Mol Inform (2013) 0.75
Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18). PLoS One (2016) 0.75
Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors. Elife (2016) 0.75
Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells. Oncotarget (2017) 0.75
Activation of GPER ameliorates experimental pulmonary hypertension in male rats. Eur J Pharm Sci (2016) 0.75
G-1 inhibits breast cancer cell growth via targeting colchicine-binding site of tubulin to interfere with microtubule assembly. Mol Cancer Ther (2017) 0.75
GPER modulators: Opportunity Nox on the heels of a class Akt. J Steroid Biochem Mol Biol (2017) 0.75
Role of GPER in the activation of endothelial nitric oxide synthase. J Steroid Biochem Mol Biol (2017) 0.75
Roles of G protein-coupled estrogen receptor GPER in metabolic regulation. J Steroid Biochem Mol Biol (2017) 0.75
GPER Mediates Functional Endothelial Aging in Renal Arteries. Pharmacology (2017) 0.75
Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives. J Steroid Biochem Mol Biol (2017) 0.75
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Molecular basis of agonism and antagonism in the oestrogen receptor. Nature (1997) 9.09
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Mol Endocrinol (2000) 5.53
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell (2001) 4.78
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol (2008) 3.20
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res (2007) 2.71
In vivo effects of a GPR30 antagonist. Nat Chem Biol (2009) 2.39
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol (2007) 2.20
Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol (2005) 2.17
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J (2009) 1.85
Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons. Mol Endocrinol (2009) 1.72
Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G protein-coupled estrogen receptor (Gper) in zebrafish (Danio rerio). Biol Reprod (2011) 1.59
Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J Immunol (2009) 1.46
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat. Eur J Neurosci (2008) 1.25
GPR30: a novel therapeutic target in estrogen-related disease. Trends Pharmacol Sci (2008) 1.25
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol (2011) 1.24
The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation. Endocrinology (2008) 1.23
High-throughput flow cytometry: validation in microvolume bioassays. Cytometry A (2003) 1.21
Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annu Rev Physiol (2007) 1.17
Androgens promote maturation and signaling in mouse oocytes independent of transcription: a release of inhibition model for mammalian oocyte meiosis. Mol Endocrinol (2003) 1.11
GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen receptor alpha (ERα) phosphorylation signals. Endocrinology (2011) 1.11
Estrogen receptor α and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models. Neuroscience (2010) 1.11
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Org Biomol Chem (2010) 0.94
Tumor-stromal interaction through the estrogen-signaling pathway in human breast cancer. Cancer Res (2005) 0.89
Estradiol inhibits chondrogenic differentiation of mesenchymal stem cells via nonclassic signaling. Arthritis Rheum (2010) 0.88
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension (2011) 3.26
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol (2008) 3.20
Simplified nutritional screening tools for patients on maintenance hemodialysis. Am J Clin Nutr (2008) 2.89
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res (2007) 2.71
In vivo effects of a GPR30 antagonist. Nat Chem Biol (2009) 2.39
Pursuing the leadlikeness concept in pharmaceutical research. Curr Opin Chem Biol (2004) 2.36
A crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol (2009) 2.29
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol (2007) 2.20
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. Cell (2003) 1.94
Quantifying the relationships among drug classes. J Chem Inf Model (2008) 1.92
Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol (2011) 1.91
GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol (2007) 1.89
FRET detection of cellular alpha4-integrin conformational activation. Biophys J (2003) 1.88
Suspension array technology: evolution of the flat-array paradigm. Trends Biotechnol (2002) 1.81
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene (2005) 1.79
HDAC6 expression is correlated with better survival in breast cancer. Clin Cancer Res (2004) 1.74
Drug Repurposing from an Academic Perspective. Drug Discov Today Ther Strateg (2011) 1.68
BDDCS applied to over 900 drugs. AAPS J (2011) 1.68
An automated PLS search for biologically relevant QSAR descriptors. J Comput Aided Mol Des (2005) 1.66
GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol (2009) 1.63
Discovery of regulators of receptor internalization with high-throughput flow cytometry. Mol Pharmacol (2012) 1.61
Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. J Immunol (2004) 1.59
GPR30: A G protein-coupled receptor for estrogen. Mol Cell Endocrinol (2007) 1.59
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell (2005) 1.55
Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol (2009) 1.55
Arrestins block G protein-coupled receptor-mediated apoptosis. J Biol Chem (2004) 1.53
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways. Nat Cell Biol (2009) 1.51
Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus. Exp Physiol (2012) 1.51
Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res (2005) 1.51
Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol (2004) 1.50
Fluorescent genetic barcoding in mammalian cells for enhanced multiplexing capabilities in flow cytometry. Cytometry A (2013) 1.48
QSAR modeling of the blood-brain barrier permeability for diverse organic compounds. Pharm Res (2008) 1.46
Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin. J Immunol (2007) 1.43
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol (2004) 1.40
Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells. Blood (2002) 1.38
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol (2007) 1.37
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol (2005) 1.37
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res (2010) 1.36
Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide. Nucl Med Biol (2009) 1.36
The ins and outs of GPR30: a transmembrane estrogen receptor. J Steroid Biochem Mol Biol (2008) 1.36
Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing. Mol Inform (2011) 1.35
Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood (2002) 1.35
Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma. Clin Cancer Res (2008) 1.33
Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection? J Comput Aided Mol Des (2008) 1.32
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am J Physiol Cell Physiol (2006) 1.29
Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol (2006) 1.28
Novel chemical space exploration via natural products. J Med Chem (2009) 1.27
Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci (2010) 1.27
G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology (2008) 1.27
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol (2009) 1.27
GPR30: a novel therapeutic target in estrogen-related disease. Trends Pharmacol Sci (2008) 1.25
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol (2011) 1.24
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem (2013) 1.24
HLA-A2-restricted glypican-3 peptide-specific CTL clones induced by peptide vaccine show high avidity and antigen-specific killing activity against tumor cells. Cancer Sci (2011) 1.23
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem (2003) 1.23