Published in Cold Spring Harb Perspect Med on November 01, 2012
Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor. Blood (2014) 1.44
Supramolecular dynamics of mucus. Cold Spring Harb Perspect Med (2012) 1.15
CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15
Mucin glycan foraging in the human gut microbiome. Front Genet (2015) 1.14
Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa. Infect Immun (2012) 0.99
Intestinal barrier in inflammatory bowel disease. World J Gastroenterol (2014) 0.97
Regulated mucin secretion from airway epithelial cells. Front Endocrinol (Lausanne) (2013) 0.95
Acidic pH increases airway surface liquid viscosity in cystic fibrosis. J Clin Invest (2016) 0.95
Reprogrammed and transmissible intestinal microbiota confer diminished susceptibility to induced colitis in TMF-/- mice. Proc Natl Acad Sci U S A (2014) 0.91
Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One (2013) 0.85
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS One (2015) 0.79
Shigella Diversity and Changing Landscape: Insights for the Twenty-First Century. Front Cell Infect Microbiol (2016) 0.78
The Interaction between Respiratory Pathogens and Mucus. Cell Host Microbe (2016) 0.76
The colonic mucus protection depends on the microbiota. Gut Microbes (2015) 0.76
Polymers in the gut compress the colonic mucus hydrogel. Proc Natl Acad Sci U S A (2016) 0.75
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Mol Biol Evol (2016) 0.75
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A (2008) 7.43
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A (2010) 4.35
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 4.24
Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol (2008) 3.63
The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol (2001) 3.53
Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. J Biol Chem (1994) 3.29
Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology (1999) 2.67
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem (2002) 2.44
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest (2009) 2.37
Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis. Lancet (2008) 2.33
Gel-forming mucins appeared early in metazoan evolution. Proc Natl Acad Sci U S A (2007) 2.16
Studies on the "insoluble" glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage. J Biol Chem (1999) 2.11
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A (2012) 2.10
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
Assembly of Weibel-Palade body-like tubules from N-terminal domains of von Willebrand factor. Proc Natl Acad Sci U S A (2008) 1.81
Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res (2009) 1.75
Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle. Mol Cell Proteomics (2007) 1.74
Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine. J Biol Chem (1993) 1.72
O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds. J Biol Chem (1998) 1.68
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J (2003) 1.67
A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn. Glycobiology (2009) 1.64
Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding. J Dent Res (1987) 1.44
von Willebrand factor assembly and secretion. J Thromb Haemost (2009) 1.43
Microbiology. Keeping bacteria at a distance. Science (2011) 1.35
An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. J Biol Chem (2003) 1.26
Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem (2004) 1.20
A new role for bicarbonate secretion in cervico-uterine mucus release. J Physiol (2010) 1.20
Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology (2004) 1.17
Function of the CysD domain of the gel-forming MUC2 mucin. Biochem J (2011) 1.16
Supramolecular dynamics of mucus. Cold Spring Harb Perspect Med (2012) 1.15
CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15
Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. Biochem J (2006) 1.12
The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small intestine. Biochem J (1995) 1.04
C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology (2004) 1.02
MUC6 mucin expression inhibits tumor cell invasion. Exp Cell Res (2011) 0.99
Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin. Biochem J (1998) 0.92
Identification of the half-cystine residues in porcine submaxillary mucin critical for multimerization through the D-domains. Roles of the CGLCG motif in the D1- and D3-domains. J Biol Chem (1998) 0.87
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A (2008) 7.43
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A (2010) 4.35
Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS One (2010) 2.82
The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol (2013) 2.65
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem (2002) 2.44
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32
Gel-forming mucins appeared early in metazoan evolution. Proc Natl Acad Sci U S A (2007) 2.16
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A (2012) 2.10
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci U S A (2006) 2.03
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat Struct Mol Biol (2005) 2.01
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem (2005) 1.88
Composition and functional role of the mucus layers in the intestine. Cell Mol Life Sci (2011) 1.86
Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res (2009) 1.75
Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle. Mol Cell Proteomics (2007) 1.74
Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer. J Natl Cancer Inst (2014) 1.69
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J (2003) 1.67
A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn. Glycobiology (2009) 1.64
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer. J Biol Chem (2005) 1.59
Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression. Am J Physiol Gastrointest Liver Physiol (2006) 1.57
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol (2013) 1.51
Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1. Mol Cell Proteomics (2009) 1.45
An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants. Am J Physiol Gastrointest Liver Physiol (2011) 1.40
Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem (2005) 1.39
Microbiology. Keeping bacteria at a distance. Science (2011) 1.35
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis (2011) 1.27
An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. J Biol Chem (2003) 1.26
TRPV1 in brain is involved in acetaminophen-induced antinociception. PLoS One (2010) 1.25
Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase. Biochem J (2002) 1.22
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev (2014) 1.21
Mucins and their O-Glycans from human bronchial epithelial cell cultures. Am J Physiol Lung Cell Mol Physiol (2004) 1.20
The gastric mucus layers: constituents and regulation of accumulation. Am J Physiol Gastrointest Liver Physiol (2008) 1.17
Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology (2004) 1.17
Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with FISH. Methods Mol Biol (2012) 1.16
Function of the CysD domain of the gel-forming MUC2 mucin. Biochem J (2011) 1.16
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol (2013) 1.16
Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary cells. Biochem J (2003) 1.15
Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC mucin. Biochem J (2006) 1.12
Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection. PLoS One (2011) 1.08
Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida albicans. Glycobiology (2005) 1.06
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am J Physiol Gastrointest Liver Physiol (2013) 1.05
Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin. FEBS J (2007) 1.03
An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics (2006) 1.01
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J Biol Chem (2013) 1.01
The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology (2002) 1.00
Helicobacter pylori infection impairs the mucin production rate and turnover in the murine gastric mucosa. Infect Immun (2012) 0.99
Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2. Glycobiology (2012) 0.98
Proteomic study of the mucin granulae in an intestinal goblet cell model. J Proteome Res (2012) 0.95
Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus brasiliensis. Glycoconj J (2002) 0.94
Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells. J Immunol (2005) 0.92
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli. Infect Immun (2013) 0.92
Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis. Glycoconj J (2009) 0.92
Default biosynthesis pathway for blood group-related glycolipids in human small intestine as defined by structural identification of linear and branched glycosylceramides in a group O Le(a-b-) nonsecretor. Glycobiology (2003) 0.91
The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem J (2008) 0.90
Localization of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology (2008) 0.90
Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43. Biochem J (2005) 0.89
Alternative splicing of the human MUC2 gene. Arch Biochem Biophys (2004) 0.88
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. Glycobiology (2012) 0.88
The goblet cell: a key player in ischaemia-reperfusion injury. Gut (2012) 0.88
CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC. J Cell Sci (2011) 0.87
CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression. Biochem Biophys Res Commun (2004) 0.87
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. PLoS One (2013) 0.86
NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion. Am J Physiol Cell Physiol (2013) 0.86
Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3. J Cell Sci (2004) 0.86
Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice. Am J Physiol Gastrointest Liver Physiol (2003) 0.86
Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for varicella-zoster-virus serology. J Virol Methods (2011) 0.86