Published in Annu Rev Physiol on January 01, 2008
Bronchial Infection in Patients With COPD and Frequent Exacerbations. | NCT03259022
Airway mucus function and dysfunction. N Engl J Med (2010) 4.41
A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science (2012) 2.98
The gastrointestinal mucus system in health and disease. Nat Rev Gastroenterol Hepatol (2013) 2.65
MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. Cancer Res (2009) 2.64
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol (2014) 2.20
Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci U S A (2012) 2.10
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev (2011) 2.05
Muc5b is required for airway defence. Nature (2013) 2.01
Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med (2011) 1.88
Mucin dynamics in intestinal bacterial infection. PLoS One (2008) 1.88
Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am J Respir Crit Care Med (2011) 1.84
Unpacking a gel-forming mucin: a view of MUC5B organization after granular release. Am J Physiol Lung Cell Mol Physiol (2009) 1.52
Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med (2009) 1.49
Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier. Sci Rep (2015) 1.45
Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology (2010) 1.41
Relationship between humidity and influenza A viability in droplets and implications for influenza's seasonality. PLoS One (2012) 1.36
RNA-Seq quantification of the human small airway epithelium transcriptome. BMC Genomics (2012) 1.28
Characterization of particle translocation through mucin hydrogels. Biophys J (2010) 1.27
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.27
Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virol J (2013) 1.19
Current status of mucins in the diagnosis and therapy of cancer. Biofactors (2009) 1.17
Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours. Histopathology (2009) 1.17
Function of the CysD domain of the gel-forming MUC2 mucin. Biochem J (2011) 1.16
Supramolecular dynamics of mucus. Cold Spring Harb Perspect Med (2012) 1.15
CFTR, mucins, and mucus obstruction in cystic fibrosis. Cold Spring Harb Perspect Med (2012) 1.15
Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med (2009) 1.11
Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol (2011) 1.11
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol (2012) 1.10
Biological hydrogels as selective diffusion barriers. Trends Cell Biol (2011) 1.10
Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching. FASEB J (2011) 1.07
AGR2 is induced in asthma and promotes allergen-induced mucin overproduction. Am J Respir Cell Mol Biol (2012) 1.06
Mucin production during prenatal and postnatal murine lung development. Am J Respir Cell Mol Biol (2011) 1.06
The innate immune function of airway epithelial cells in inflammatory lung disease. Eur Respir J (2015) 1.05
Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells. Am J Respir Crit Care Med (2009) 1.05
Barrier function of airway tract epithelium. Tissue Barriers (2013) 1.02
Structure and biological roles of mucin-type O-glycans at the ocular surface. Ocul Surf (2010) 1.01
Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus. Infect Immun (2014) 1.00
The role of gut microbiota in programming the immune phenotype. J Dev Orig Health Dis (2013) 0.99
Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis (2012) 0.99
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem (2013) 0.99
Clinical issues of mucus accumulation in COPD. Int J Chron Obstruct Pulmon Dis (2014) 0.99
Mucin-type O-glycans and their roles in intestinal homeostasis. Glycobiology (2013) 0.98
Perspectives on mucus properties and formation--lessons from the biochemical world. Cold Spring Harb Perspect Med (2012) 0.97
The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets. J Virol (2013) 0.96
MUC5B leads to aggressive behavior of breast cancer MCF7 cells. PLoS One (2012) 0.96
The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation. Curr Opin Allergy Clin Immunol (2013) 0.96
Regulated mucin secretion from airway epithelial cells. Front Endocrinol (Lausanne) (2013) 0.95
Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med (2015) 0.95
Acidic pH increases airway surface liquid viscosity in cystic fibrosis. J Clin Invest (2016) 0.95
Airway hydration and COPD. Cell Mol Life Sci (2015) 0.94
Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin. J Biol Chem (2014) 0.94
Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation. J Virol (2012) 0.94
The characterization of the first anti-mouse Muc6 antibody shows an increased expression of the mucin in pancreatic tissue of Cftr-knockout mice. Histochem Cell Biol (2010) 0.93
Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes. Transl Res (2013) 0.93
Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates. Biochemistry (2014) 0.92
Tissue distibution of murine Muc19/smgc gene products. J Histochem Cytochem (2010) 0.92
The extraordinarily complex but highly structured organization of intestinal mucus-gel unveiled in multicolor images. PLoS One (2011) 0.92
Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC. PLoS One (2011) 0.92
The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23. PLoS Genet (2011) 0.91
Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study. J Proteome Res (2012) 0.90
Glycosylation of human fetal mucins: a similar repertoire of O-glycans along the intestinal tract. Glycoconj J (2008) 0.90
Genome reference and sequence variation in the large repetitive central exon of human MUC5AC. Am J Respir Cell Mol Biol (2014) 0.90
Expanding proteostasis by membrane trafficking networks. Cold Spring Harb Perspect Biol (2013) 0.89
Role of mucins in the skin during benign and malignant conditions. Cancer Lett (2010) 0.89
Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol (2012) 0.89
Exploring the transcriptome of Atlantic salmon (Salmo salar) skin, a major defense organ. Mar Biotechnol (NY) (2012) 0.89
Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells. J Histochem Cytochem (2008) 0.89
Increased susceptibility to pulmonary Pseudomonas infection in Splunc1 knockout mice. J Immunol (2013) 0.89
Role of epithelial mucins during airway infection. Pulm Pharmacol Ther (2011) 0.89
Mucosal Inflammatory Response to Salmonella typhimurium Infection. Front Immunol (2014) 0.87
A beneficiary role for neuraminidase in influenza virus penetration through the respiratory mucus. PLoS One (2014) 0.86
A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis. Development (2014) 0.86
Diagnostic and prognostic significances of MUC5B and TTF-1 expressions in resected non-small cell lung cancer. Sci Rep (2015) 0.86
Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection. Virus Res (2011) 0.85
Genome wide analysis of the bovine mucin genes and their gastrointestinal transcription profile. BMC Genomics (2011) 0.85
Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains. Mol Biotechnol (2013) 0.85
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids. Chem Phys Lipids (2014) 0.84
Studying mucin secretion from human bronchial epithelial cell primary cultures. Methods Mol Biol (2012) 0.84
Coarse-grained modeling of mucus barrier properties. Biophys J (2012) 0.84
Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model. Physiol Rep (2015) 0.84
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways. Physiol Rev (2016) 0.84
Mucin production and mucous cell metaplasia in otitis media. Int J Otolaryngol (2012) 0.83
In vitro spatial and temporal analysis of Mycoplasma pneumoniae colonization of human airway epithelium. Infect Immun (2013) 0.83
Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins. Infect Immun (2014) 0.82
NOD-like receptors in intestinal homeostasis and epithelial tissue repair. Int J Mol Sci (2014) 0.82
Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs. PLoS One (2012) 0.82
Degradation of MUC7 and MUC5B in human saliva. PLoS One (2013) 0.82
Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers. BMC Med Genomics (2012) 0.81
LPS increases MUC5AC by TACE/TGF-α/EGFR pathway in human intrahepatic biliary epithelial cell. Biomed Res Int (2013) 0.81
A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube. PLoS Genet (2012) 0.81
Cystic fibrosis: an inherited disease affecting mucin-producing organs. Int J Biochem Cell Biol (2014) 0.81
Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans. Infect Immun (2014) 0.81
MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling. Oncogene (2016) 0.80
Trichuris muris research revisited: a journey through time. Parasitology (2013) 0.80
Interactions between human neutrophils and mucin-coated surfaces. J Mater Sci Mater Med (2008) 0.80
Abnormal expression of Muc5b in Cftr-null mice and in mammary tumors of MMTV-ras mice. Histochem Cell Biol (2011) 0.80
Coarse-grained Monte Carlo simulations of mucus: structure, dynamics, and thermodynamics. Biophys J (2010) 0.80
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 4.24
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria. Am J Gastroenterol (2010) 3.32
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection. J Clin Invest (2007) 2.90
Mucin dynamics in intestinal bacterial infection. PLoS One (2008) 1.88
IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. Am J Gastroenterol (2007) 1.71
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy. PLoS Pathog (2009) 1.69
Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry. Clin Cancer Res (2010) 1.32
The interplay between endoplasmic reticulum stress and inflammation. Immunol Cell Biol (2012) 1.31
Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Pancreas (2003) 1.30
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.27
Campylobacter jejuni response to human mucin MUC2: modulation of colonization and pathogenicity determinants. J Med Microbiol (2008) 1.19
A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Ann Am Thorac Soc (2014) 1.17
Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast Cancer Res (2005) 1.14
The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Hum Pathol (2007) 1.14
Mucins in inflammatory bowel diseases and colorectal cancer. J Gastroenterol Hepatol (2012) 1.14
The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut (2011) 1.13
Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med (2009) 1.11
Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Sci (2002) 1.10
β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum (2012) 1.10
Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Mod Pathol (2013) 1.04
Expression of the cell surface mucin gene family in adenocarcinomas. Int J Oncol (2004) 1.04
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cell Microbiol (2012) 1.04
IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology (2012) 1.02
Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate. Biol Cell (2004) 1.01
Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis (2012) 0.99
Localized suppression of inflammation at sites of Helicobacter pylori colonization. Infect Immun (2011) 0.98
Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions. Helicobacter (2007) 0.96
ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice. Arthritis Rheumatol (2014) 0.96
Listeria monocytogenes internalins bind to the human intestinal mucin MUC2. Arch Microbiol (2008) 0.96
KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population. Am J Gastroenterol (2010) 0.95
Endocrine evidence that silvering, a secondary metamorphosis in the eel, is a pubertal rather than a metamorphic event. Neuroendocrinology (2006) 0.93
Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol (2014) 0.92
Expression of MUC1 splice variants in benign and malignant ovarian tumours. Int J Cancer (2002) 0.92
Multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family. PLoS One (2012) 0.91
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway. Am J Respir Cell Mol Biol (2012) 0.90
Immunohistochemical study of mucin expression in periampullary adenomyoma. J Hepatobiliary Pancreat Sci (2009) 0.89
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. J Exp Med (2013) 0.88
Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment. PLoS One (2013) 0.88
Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells. BMC Cell Biol (2009) 0.86
Matrix metalloproteinases vary with airway microbiota composition and lung function in non-cystic fibrosis bronchiectasis. Ann Am Thorac Soc (2015) 0.86
A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis. Development (2014) 0.86
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut (2012) 0.86
Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One (2013) 0.85
Pituitary gonadotropins FSH and LH are oppositely regulated by the activin/follistatin system in a basal teleost, the eel. Gen Comp Endocrinol (2011) 0.85
O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose. Glycobiology (2012) 0.84
Comparative evolutionary histories of kisspeptins and kisspeptin receptors in vertebrates reveal both parallel and divergent features. Front Endocrinol (Lausanne) (2012) 0.84
Muc1 limits Helicobacter felis binding to gastric epithelial cells but does not limit colonization and gastric pathology following infection. Helicobacter (2008) 0.84
T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation. Methods Mol Biol (2012) 0.83
Cortisol mobilizes mineral stores from vertebral skeleton in the European eel: an ancestral origin for glucocorticoid-induced osteoporosis? J Endocrinol (2009) 0.83
Techniques for assessment of interactions of mucins with microbes and parasites in vitro and in vivo. Methods Mol Biol (2012) 0.83
Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase. World J Gastroenterol (2011) 0.82
Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates. Fungal Biol (2012) 0.81
Aberrant mucin glycoprotein patterns of chronic rhinosinusitis patients with bacterial biofilms. Am J Rhinol Allergy (2011) 0.80
A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut (2012) 0.79
Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after immunomagnetic separation. J Basic Microbiol (2012) 0.79
Looking for the bird Kiss: evolutionary scenario in sauropsids. BMC Evol Biol (2014) 0.79
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model. Inflamm Bowel Dis (2015) 0.79
Thyroid hormone-induced demineralisation of the vertebral skeleton of the eel, Anguilla anguilla. Gen Comp Endocrinol (2006) 0.79
Detecting, visualising, and quantifying mucins. Methods Mol Biol (2012) 0.77
Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. Mod Pathol (2013) 0.75
MUC5AC and inflammatory mediators associated with respiratory outcomes in the British 1946 birth cohort. Respirology (2013) 0.75
The expression of mucin genes and the presence of mucin gene products in the equine endometrium. Res Vet Sci (2013) 0.75