Published in Mol Biol Cell on November 07, 2012
Whole genome expression profiling associates activation of unfolded protein response with impaired production and release of epinephrine after recurrent hypoglycemia. PLoS One (2017) 1.39
Diversity and selectivity in mRNA translation on the endoplasmic reticulum. Nat Rev Mol Cell Biol (2015) 1.04
Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proc Natl Acad Sci U S A (2013) 0.91
Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations. Hum Mol Genet (2013) 0.91
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences. Front Genet (2013) 0.90
Physiological roles of regulated Ire1 dependent decay. Front Genet (2014) 0.89
Regulation of sumo mRNA during endoplasmic reticulum stress. PLoS One (2013) 0.86
UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci (2013) 0.85
Endoplasmic reticulum quality control in cancer: Friend or foe. Semin Cancer Biol (2015) 0.83
Quality control: Is there quality control of localized mRNAs? J Cell Biol (2014) 0.83
Can't RIDD off viruses. Front Microbiol (2014) 0.83
The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci (2015) 0.82
Drosophila as a model for unfolded protein response research. BMB Rep (2015) 0.82
MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression. RNA (2013) 0.82
The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans. Virulence (2013) 0.80
Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress. G3 (Bethesda) (2015) 0.78
Endoplasmic reticulum quality control and systemic amyloid disease: Impacting protein stability from the inside out. IUBMB Life (2015) 0.78
An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response. J Cell Sci (2016) 0.77
Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1. PLoS One (2014) 0.76
Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status. Mol Biol Cell (2015) 0.76
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol (2001) 66.87
SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods (2011) 33.90
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell (2000) 13.44
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell (1999) 9.05
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell (1993) 6.82
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Science (2006) 6.75
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol (1998) 5.66
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell (2001) 5.39
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell (2009) 4.65
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. J Biol Chem (2000) 4.37
Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell (1998) 2.39
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. J Biol Chem (2009) 1.65
The unfolded protein response in secretory cell function. Annu Rev Genet (2012) 1.49
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. RNA (2008) 1.49
IRE1α activation protects mice against acetaminophen-induced hepatotoxicity. J Exp Med (2012) 1.30
Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. Methods Mol Biol (2008) 1.28
p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum. PLoS Biol (2012) 1.11
Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Mol Biol Cell (2011) 1.10
Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol (2009) 4.51
The unfolded protein response in secretory cell function. Annu Rev Genet (2012) 1.49
Analysis of Dom34 and its function in no-go decay. Mol Biol Cell (2009) 1.37
In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila. G3 (Bethesda) (2014) 0.86
Regulation of sumo mRNA during endoplasmic reticulum stress. PLoS One (2013) 0.86
Fluorescent RNA labeling using self-alkylating ribozymes. ACS Chem Biol (2014) 0.82
Presence of a peptide component of thymosin fraction-5 manifesting discrete cytostatic properties in HL-60 human promyelocytic leukemia cells. Int Immunopharmacol (2005) 0.81
Cytoplasmic organelles on the road to mRNA decay. Biochim Biophys Acta (2013) 0.80
Rumpel-Leede Phenomenon in a Patient with Laboratory Markers Positive for Sjögren Disease. A A Case Rep (2016) 0.75
Picture story. A state-of-the-Arp structure. Nat Struct Biol (2002) 0.75