Published in Nature on January 03, 2002
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell (2011) 10.56
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol (2012) 8.52
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Orchestrating the unfolded protein response in health and disease. J Clin Invest (2002) 7.60
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci U S A (2003) 7.57
Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol (2006) 6.47
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell (2011) 6.05
The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell (2009) 4.65
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
Translational control in the endoplasmic reticulum stress response. J Clin Invest (2002) 4.56
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
tRNA biology charges to the front. Genes Dev (2010) 4.07
XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol (2004) 4.03
A mitochondrial specific stress response in mammalian cells. EMBO J (2002) 3.95
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Mol Cell (2008) 3.91
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell (2007) 3.76
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28
Stress-induced gene expression requires programmed recovery from translational repression. EMBO J (2003) 3.26
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science (2011) 3.19
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest (2005) 3.16
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A (2006) 2.90
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene (2012) 2.82
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81
An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature (2010) 2.81
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell (2011) 2.75
Cellular stress responses: cell survival and cell death. Int J Cell Biol (2010) 2.74
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol (2002) 2.72
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes (2008) 2.71
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol (2006) 2.62
Revealing global regulatory perturbations across human cancers. Mol Cell (2009) 2.62
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet (2009) 2.60
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest (2008) 2.58
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat Med (2010) 2.48
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Unfolded protein response in a Drosophila model for retinal degeneration. EMBO J (2006) 2.45
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med (2011) 2.40
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics (2006) 2.29
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci U S A (2010) 2.23
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell (2013) 2.20
Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. PLoS Pathog (2008) 2.16
The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A (2006) 2.10
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem (2005) 2.08
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J Cell Biol (2004) 2.07
The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol (2007) 2.07
An endoplasmic reticulum stress response in Arabidopsis is mediated by proteolytic processing and nuclear relocation of a membrane-associated transcription factor, bZIP28. Plant Cell (2007) 2.05
Flavivirus infection activates the XBP1 pathway of the unfolded protein response to cope with endoplasmic reticulum stress. J Virol (2006) 2.02
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A (2009) 2.00
Proteostasis control by the unfolded protein response. Nat Cell Biol (2015) 1.99
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature (2012) 1.98
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal (2009) 1.98
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS One (2008) 1.95
Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress. Mol Biol Cell (2006) 1.94
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood (2007) 1.92
Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. Int J Cell Biol (2010) 1.91
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr Opin Cell Biol (2004) 1.90
Xbp1s-negative tumor B cells and pre-plasmablasts mediate therapeutic proteasome inhibitor resistance in multiple myeloma. Cancer Cell (2013) 1.88
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy. Int J Cell Biol (2010) 1.86
West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis. J Virol (2007) 1.86
Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function. PLoS Biol (2007) 1.82
Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol (2010) 1.81
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res (2010) 1.78
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Endoplasmic reticulum stress in disorders of myelinating cells. Nat Neurosci (2009) 1.76
Portability and fidelity of RNA-repair systems. Proc Natl Acad Sci U S A (2004) 1.76
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.75
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation. Invest Ophthalmol Vis Sci (2012) 1.74
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response. PLoS Biol (2004) 1.73
The SKIV2L RNA exosome limits activation of the RIG-I-like receptors. Nat Immunol (2014) 1.73
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A (2013) 1.73
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J (2009) 1.72
Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem (2010) 1.72
The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24
Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol (2003) 6.34
Endoplasmic reticulum stress signaling in disease. Physiol Rev (2006) 5.90
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol (2004) 5.44
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity (2005) 4.53
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol (2007) 4.45
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab (2006) 4.11
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab (2009) 3.51
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science (2011) 3.29
Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell (2008) 3.29
Stress-induced gene expression requires programmed recovery from translational repression. EMBO J (2003) 3.26
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell (2010) 3.26
The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci (2010) 3.06
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice. Neuron (2008) 2.95
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci U S A (2002) 2.93
Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci (2002) 2.83
Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes (2002) 2.74
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response. J Cell Biol (2002) 2.72
Activating transcription factor 4 is translationally regulated by hypoxic stress. Mol Cell Biol (2004) 2.68
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol (2002) 2.62
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell (2007) 2.61
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell (2006) 2.54
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell (2010) 2.51
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A (2012) 2.45
Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol (2009) 2.42
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37
Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One (2009) 2.30
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics (2006) 2.29
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem (2005) 2.25
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A (2009) 2.22
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol (2011) 2.20
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol Cell Biol (2006) 2.16
Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells. J Cell Biol (2003) 2.15
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev Cell (2007) 2.10
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol (2004) 2.10
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem (2005) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS One (2008) 1.95
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol (2010) 1.87
Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. Mol Cell (2005) 1.84
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab (2005) 1.83
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses. EMBO J (2006) 1.79
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. Development (2006) 1.79