Patrick M Giguère

Author PubWeight™ 8.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev 2011 1.98
2 The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity 2012 1.44
3 The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta 2007 1.29
4 Retracted Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Structure 2008 1.02
5 Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica. PLoS Pathog 2012 0.83
6 RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol 2010 0.83
7 The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq. Mol Cell Biochem 2007 0.78
8 Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents. J Med Chem 2015 0.77
9 Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists. J Med Chem 2016 0.75