Published in PLoS Pathog on November 15, 2012
G protein signaling in the parasite Entamoeba histolytica. Exp Mol Med (2013) 0.85
Structural determinants of ubiquitin conjugation in Entamoeba histolytica. J Biol Chem (2012) 0.79
Evidence for a bacterial lipopolysaccharide-recognizing G-protein-coupled receptor in the bacterial engulfment by Entamoeba histolytica. Eukaryot Cell (2013) 0.78
RGS21, a regulator of taste and mucociliary clearance? Laryngoscope (2013) 0.75
Entamoeba histolytica RacC selectively engages p21-activated kinase effectors. Biochemistry (2015) 0.75
A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Properties and Characterization of the Protein. PLoS One (2015) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol (2011) 220.97
T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc (2012) 35.75
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res (2011) 9.15
A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. Protein Expr Purif (2002) 5.72
Amebiasis. N Engl J Med (2003) 5.63
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature (1989) 5.38
Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol (2008) 5.30
The Ras superfamily at a glance. J Cell Sci (2005) 4.83
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells. Annu Rev Biophys (2008) 3.48
WHO/PAHO/UNESCO report. A consultation with experts on amoebiasis. Mexico City, Mexico 28-29 January, 1997. Epidemiol Bull (1997) 2.74
Lipid modifications of trimeric G proteins. J Biol Chem (1995) 2.39
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev Cell (2007) 2.10
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica. Annu Rev Microbiol (2002) 2.06
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
Pore-forming peptide of pathogenic Entamoeba histolytica. Proc Natl Acad Sci U S A (1991) 1.63
Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family. PLoS Pathog (2008) 1.46
A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica. Mol Biol Cell (2005) 1.41
Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. Mol Pharmacol (2009) 1.38
Calcium binding protein 1 of the protozoan parasite Entamoeba histolytica interacts with actin and is involved in cytoskeleton dynamics. J Cell Sci (2004) 1.37
Tissue destruction and invasion by Entamoeba histolytica. Trends Parasitol (2011) 1.34
Tetracycline-controlled gene expression in Entamoeba histolytica. Mol Biochem Parasitol (1997) 1.28
High prevalence rate of Entamoeba histolytica asymptomatic infection in a rural Mexican community. Am J Trop Med Hyg (2005) 1.23
Involvement of p21racA, phosphoinositide 3-kinase, and vacuolar ATPase in phagocytosis of bacteria and erythrocytes by Entamoeba histolytica: suggestive evidence for coincidental evolution of amebic invasiveness. Infect Immun (1997) 1.20
Role of the galactose lectin of Entamoeba histolytica in adherence-dependent killing of mammalian cells. Infect Immun (1991) 1.17
Calcium-binding protein 1 of Entamoeba histolytica transiently associates with phagocytic cups in a calcium-independent manner. Cell Microbiol (2008) 1.11
Antisense inhibition of amoebapore expression in Entamoeba histolytica causes a decrease in amoebic virulence. Mol Microbiol (1999) 1.10
Diversity of clinical isolates of Entamoeba histolytica in Japan. Arch Med Res (2006) 1.09
The alpha-subunit of the Arabidopsis heterotrimeric G protein, GPA1, is a regulator of transpiration efficiency. Plant Physiol (2010) 1.08
Glucose attenuation of auxin-mediated bimodality in lateral root formation is partly coupled by the heterotrimeric G protein complex. PLoS One (2010) 1.05
Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics. Trends Pharmacol Sci (2007) 1.04
Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF. Protein Sci (2011) 1.04
A C2 domain protein kinase initiates phagocytosis in the protozoan parasite Entamoeba histolytica. Nat Commun (2011) 1.04
Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals. Proc Natl Acad Sci U S A (2010) 1.02
Rab11B small GTPase regulates secretion of cysteine proteases in the enteric protozoan parasite Entamoeba histolytica. Cell Microbiol (2007) 1.02
Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica. Mol Biol Cell (1998) 1.00
Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal (2010) 0.98
Increased expression of the major cysteine proteinases by stable episomal transfection underlines the important role of EhCP5 for the pathogenicity of Entamoeba histolytica. Mol Biochem Parasitol (2006) 0.97
A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol (2006) 0.97
Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis. Int J Parasitol (2010) 0.97
Serum-dependent selective expression of EhTMKB1-9, a member of Entamoeba histolytica B1 family of transmembrane kinases. PLoS Pathog (2010) 0.96
Endoplasmic reticulum stress-sensing mechanism is activated in Entamoeba histolytica upon treatment with nitric oxide. PLoS One (2012) 0.95
A Dictyostelium chalone uses G proteins to regulate proliferation. BMC Biol (2009) 0.95
The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica. J Cell Sci (1998) 0.94
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways. Arch Med Res (2006) 0.94
Stable transfection of Entamoeba histolytica trophozoites by lipofection. Arch Med Res (1997) 0.94
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS One (2009) 0.93
Evolution of a signaling nexus constrained by protein interfaces and conformational States. PLoS Comput Biol (2010) 0.93
Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding. J Biol Chem (1993) 0.93
G protein signaling in yeast: new components, new connections, new compartments. Science (2006) 0.92
Targets of the Entamoeba histolytica transcription factor URE3-BP. PLoS Negl Trop Dis (2008) 0.91
A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance. Methods Mol Biol (2010) 0.91
Analysis of the protein kinome of Entamoeba histolytica. Proteins (2008) 0.91
A unique Rab GTPase, EhRabA, is involved in motility and polarization of Entamoeba histolytica cells. Mol Biochem Parasitol (2005) 0.89
Crystal structure and trimer-monomer transition of N-terminal domain of EhCaBP1 from Entamoeba histolytica. Biophys J (2010) 0.88
Amoebic liver abscess production by Entamoeba dispar. Ann Hepatol (2011) 0.86
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. J Biol Chem (2010) 0.86
A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis. PLoS Pathog (2012) 0.85
A novel class of cysteine protease receptors that mediate lysosomal transport. Cell Microbiol (2012) 0.85
Entamoeba histolytica: identification of EhGPCR-1, a novel putative G protein-coupled receptor that binds to EhRabB. Exp Parasitol (2005) 0.84
Entamoeba histolytica: inhibition of cellular functions by overexpression of EhGEF1, a novel Rho/Rac guanine nucleotide exchange factor. Exp Parasitol (2005) 0.83
EhGEF3, a novel Dbl family member, regulates EhRacA activation during chemotaxis and capping in Entamoeba histolytica. Cell Motil Cytoskeleton (2007) 0.79
Entamoeba histolytica: alterations in EhRabB protein in a phagocytosis deficient mutant correlate with the Entamoeba dispar RabB sequence. Exp Parasitol (2005) 0.79
Lipids induce expression of serum-responsive transmembrane kinase EhTMKB1-9 in an early branching eukaryote Entamoeba histolytica. Sci Rep (2012) 0.79
EhGEF2, a Dbl-RhoGEF from Entamoeba histolytica has atypical biochemical properties and participates in essential cellular processes. Mol Biochem Parasitol (2006) 0.78
Entamoeba histolytica: identification of functional Gs and Gi proteins as possible signal transduction elements in the interaction of trophozoites with fibronectin. Exp Parasitol (1998) 0.78
Entamoeba histolytica liver abscess. CMAJ (2010) 0.76
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol (2008) 3.49
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature (2005) 3.31
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana. Proc Natl Acad Sci U S A (2004) 2.48
Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov (2002) 2.47
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (2003) 2.46
Side chain and backbone contributions of Phe508 to CFTR folding. Nat Struct Mol Biol (2004) 2.43
A seven-transmembrane RGS protein that modulates plant cell proliferation. Science (2003) 2.41
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med (2003) 2.33
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature (2002) 2.30
Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J (2002) 2.27
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Return of the GDI: the GoLoco motif in cell division. Annu Rev Biochem (2004) 2.16
Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell (2005) 2.16
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell (2004) 2.09
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J (2002) 2.07
Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron (2005) 2.06
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A (2009) 2.02
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (2005) 1.98
LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights. Mol Pharmacol (2007) 1.81
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest (2009) 1.79
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol (2005) 1.72
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology (2006) 1.69
X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J Mol Biol (2010) 1.61
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol (2007) 1.59
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Crystal structure of the multifunctional Gbeta5-RGS9 complex. Nat Struct Mol Biol (2008) 1.52
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51
Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res (2004) 1.49
Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. J Mol Biol (2007) 1.48
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Mol Cell Biol (2006) 1.46
The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity (2012) 1.44
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry (2007) 1.44
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Mol Cell Biol (2002) 1.43
Changes at the KinA PAS-A dimerization interface influence histidine kinase function. Biochemistry (2008) 1.43
Crystal structure of the human PRMT5:MEP50 complex. Proc Natl Acad Sci U S A (2012) 1.42
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer. PLoS Biol (2008) 1.41
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations. J Mol Biol (2005) 1.37
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division. Development (2005) 1.37
Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid". Science (2007) 1.37
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell (2008) 1.32
Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism. EMBO J (2007) 1.31
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A (2010) 1.30
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. J Biol Chem (2008) 1.29
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face. Biochim Biophys Acta (2007) 1.29
Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. J Biol Chem (2002) 1.28
Diffraction data analysis in the presence of radiation damage. Acta Crystallogr D Biol Crystallogr (2010) 1.27
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nat Struct Mol Biol (2004) 1.26
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem (2009) 1.24
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett (2012) 1.22
A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Anal Biochem (2005) 1.22
Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (2004) 1.21
Localization and structure of the ankyrin-binding site on beta2-spectrin. J Biol Chem (2008) 1.21
Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex. Structure (2006) 1.19
Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer. J Am Chem Soc (2011) 1.19
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem (2009) 1.16
Retracted Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A (2007) 1.14
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes (2010) 1.14
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. J Biol Chem (2011) 1.13
Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochem J (2004) 1.13
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. Mol Pharmacol (2006) 1.13
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure (2008) 1.12
Computational design of a symmetric homodimer using β-strand assembly. Proc Natl Acad Sci U S A (2011) 1.12