Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 3899696)

Published in Oncogene on November 26, 2012

Authors

S Sankar1, R Bell, B Stephens, R Zhuo, S Sharma, D J Bearss, S L Lessnick

Author Affiliations

1: Department of Oncological Sciences, Huntsman Cancer Institute, School of Medicine, Salt Lake City, UT, USA.

Articles citing this

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. Genome Res (2013) 1.11

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1. Cell Rep (2015) 1.05

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia (2014) 1.03

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res (2014) 0.96

MicroRNAs in Ewing Sarcoma. Front Oncol (2013) 0.90

Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. J Clin Invest (2014) 0.90

A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol (2013) 0.89

Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells. PLoS One (2013) 0.87

Twenty Years on: What Do We Really Know about Ewing Sarcoma and What Is the Path Forward? Crit Rev Oncog (2015) 0.85

KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. BMC Cancer (2014) 0.83

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor. Clin Cancer Res (2016) 0.83

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell (2014) 0.83

EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma. Genes Cancer (2013) 0.82

Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes. Int J Mol Sci (2015) 0.82

BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. PLoS One (2013) 0.81

New strategies in ewing sarcoma: lost in translation? Clin Cancer Res (2014) 0.81

Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma. Oncogene (2013) 0.80

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma. Front Oncol (2015) 0.80

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors. Cancer Res (2016) 0.79

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting. Oncotarget (2016) 0.78

Potential approaches to the treatment of Ewing's sarcoma. Oncotarget (2016) 0.77

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1. Oncotarget (2015) 0.77

RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein. Oncotarget (2016) 0.76

BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Oncotarget (2016) 0.76

EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer (2015) 0.76

Recent advances in targeted therapy for Ewing sarcoma. F1000Res (2016) 0.75

ROMA: Representation and Quantification of Module Activity from Target Expression Data. Front Genet (2016) 0.75

Proteasomal degradation of the EWS-FLI1 fusion protein is regulated by a single lysine residue. J Biol Chem (2016) 0.75

High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility. Proc Natl Acad Sci U S A (2016) 0.75

Structure-function based molecular relationships in Ewing's sarcoma. Biomed Res Int (2015) 0.75

Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget (2016) 0.75

Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma. J Clin Invest (2016) 0.75

Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States. Cancer Res (2016) 0.75

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth. Proc Natl Acad Sci U S A (2017) 0.75

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene (2017) 0.75

The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis. Oncogene (2017) 0.75

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature (1992) 7.68

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev (2007) 3.56

ETS transcription factors and their emerging roles in human cancer. Eur J Cancer (2005) 3.55

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol (2004) 3.33

Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet (2010) 3.29

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell (2006) 3.29

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A (1993) 3.07

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol (1993) 2.84

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell (2002) 2.28

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma. Mol Cell Biol (1994) 2.18

Microsatellites as EWS/FLI response elements in Ewing's sarcoma. Proc Natl Acad Sci U S A (2008) 2.06

The rationale for targeting the LOX family in cancer. Nat Rev Cancer (2012) 2.02

Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc (2009) 1.94

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors. Cancer Res (2002) 1.82

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res (2006) 1.80

Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways. Clin Cancer Res (2011) 1.80

A molecular function map of Ewing's sarcoma. PLoS One (2009) 1.69

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle (2007) 1.66

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Nat Genet (1999) 1.57

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes Dev (2011) 1.56

Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene (1995) 1.51

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Oncogene (1998) 1.41

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One (2008) 1.41

Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle (2006) 1.27

Microarray analysis of Ewing's sarcoma family of tumours reveals characteristic gene expression signatures associated with metastasis and resistance to chemotherapy. Eur J Cancer (2008) 1.18

EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Cancer Res (2009) 1.17

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle (2006) 1.14

Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol (2012) 1.09

Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program. Pediatr Blood Cancer (2009) 1.08

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure. Cell Cycle (2008) 0.98

Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene (2004) 0.96

The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Cancer Res (2001) 0.94

Articles by these authors

Surgical training: an objective assessment of recent changes for a single health board. BMJ (1997) 9.28

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science (1997) 8.90

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat Genet (1996) 6.43

Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. Nucleic Acids Res (1988) 4.19

Appropriateness of the decision to transfer nursing facility residents to the hospital. J Am Geriatr Soc (2000) 3.99

Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic. Clin Infect Dis (2000) 3.72

Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc Natl Acad Sci U S A (1998) 3.58

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res (1997) 3.55

Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med (1996) 3.41

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet (1994) 3.17

Intravenous tissue-type plasminogen activator for treatment of acute stroke: the Standard Treatment with Alteplase to Reverse Stroke (STARS) study. JAMA (2000) 3.17

Access to coronary artery bypass surgery by race/ethnicity and gender among patients who are appropriate for surgery. Med Care (1999) 3.07

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A (1993) 3.07

Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol (1998) 2.96

Exploring dimensions of access to medical care. Health Serv Res (1983) 2.91

Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med (2016) 2.89

Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. J Am Coll Cardiol (2000) 2.89

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol (1993) 2.84

Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol (2001) 2.72

Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli. Science (1987) 2.65

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing. Nat Struct Biol (1998) 2.59

Epidemiology of trauma deaths. Am J Surg (1980) 2.58

Transferable EST-SSR markers for the study of polymorphism and genetic diversity in bread wheat. Mol Genet Genomics (2003) 2.55

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci U S A (1992) 2.54

Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc (2006) 2.51

Utility values and age-related macular degeneration. Arch Ophthalmol (2000) 2.48

Cardiac fatigue following prolonged endurance exercise of differing distances. Med Sci Sports Exerc (2000) 2.47

Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proc Natl Acad Sci U S A (2001) 2.43

Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci (1996) 2.34

Residual disease following unplanned excision of soft-tissue sarcoma of an extremity. J Bone Joint Surg Am (1996) 2.26

Matrix metalloproteinases and diseases of the CNS. Trends Neurosci (1998) 2.24

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A (1995) 2.24

Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport. Proc Natl Acad Sci U S A (2001) 2.24

Laparoscopic kidney transplantation: an initial experience. Am J Transplant (2011) 2.24

Microbial scleritis-experience from a developing country. Eye (Lond) (2008) 2.24

Microbiologic spectrum and susceptibility of isolates: part I. Postoperative endophthalmitis. Endophthalmitis Research Group. Am J Ophthalmol (1999) 2.22

Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab (2005) 2.20

The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J (1990) 2.17

The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. J Neurosci (1997) 2.16

Sex differences in gastric alcohol dehydrogenase activity in Sprague-Dawley rats. Gastroenterology (1992) 2.16

Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Cancer Res (1998) 2.11

Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J Immunol (2000) 2.11

Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A (1987) 2.11

Myocardial infarction in the young. J Assoc Physicians India (1991) 2.06

The Kropp-onlay procedure (Pippi Salle procedure): a simplification of the technique of urethral lengthening. Preliminary results in eight patients. Br J Urol (1995) 2.05

Heat shock regulatory gene rpoH mRNA level increases after heat shock in Escherichia coli. J Bacteriol (1986) 2.04

Chlorhexidine cleaning of re-usable bougies. Anaesthesia (2013) 2.04

Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J Cell Sci (2002) 2.04

A randomized trial of empyema therapy. Chest (1997) 2.04

The Babinski sign: 100 years on. BMJ (1996) 2.01

Is it time to say goodbye to thoracotomy for treatment of rheumatic mitral stenosis? J Postgrad Med (1992) 2.01

Management of idiopathic obstruction of the hepatic and suprahepatic inferior vena cava with a self-expanding metallic stent. Cathet Cardiovasc Diagn (1996) 1.99

Quality medicines for the poor: experience of the Delhi programme on rational use of drugs. Health Policy Plan (2005) 1.95

A case of multi-organ failure. Int J Clin Pract (2007) 1.94

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Mol Psychiatry (2013) 1.93

The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. Br J Cancer (2010) 1.91

Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J Med Genet (2002) 1.91

Psychoeducational intervention for caregivers of Indian patients with schizophrenia: a randomised-controlled trial. Acta Psychiatr Scand (2009) 1.90

13-cis-retinoic acid in the treatment of oral leukoplakia. N Engl J Med (1986) 1.90

Process development for the removal of lead and chromium from aqueous solutions using red mud--an aluminium industry waste. Water Res (2001) 1.89

Comparison of echo and MRI in the imaging evaluation of intracardiac masses. Cardiovasc Intervent Radiol (2004) 1.89

Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol (1994) 1.89

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol (2000) 1.87

Uses of the 1980 census for Hispanic health services research. Am J Public Health (1983) 1.87

Altered immune responses in interleukin 10 transgenic mice. J Exp Med (1997) 1.85

In vitro susceptibility of bacterial keratitis pathogens to ciprofloxacin. Emerging resistance. Ophthalmology (1999) 1.84

Fair society, healthy lives. Public Health (2012) 1.84

Multiple control elements for the uvrC gene unit of Escherichia coli. Nucleic Acids Res (1986) 1.84

Peptide models for inherited neurodegenerative disorders: conformation and aggregation properties of long polyglutamine peptides with and without interruptions. FEBS Lett (1999) 1.83

Surgical debulking and intraperitoneal chemotherapy for established peritoneal metastases from colon and appendix cancer. Ann Surg Oncol (2001) 1.83

Utility values associated with blindness in an adult population. Br J Ophthalmol (2001) 1.79

A single Photorhabdus gene, makes caterpillars floppy (mcf), allows Escherichia coli to persist within and kill insects. Proc Natl Acad Sci U S A (2002) 1.79

Preventing type 2 diabetes after gestational diabetes: women's experiences and implications for diabetes prevention interventions. Diabet Med (2013) 1.79

Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J (2010) 1.78

Visual outcomes following the use of intravitreal steroids in the treatment of postoperative endophthalmitis. Ophthalmology (2000) 1.78

Efficacy of personal symptom and family history questionnaires when screening for inherited cardiac pathologies: the role of electrocardiography. Br J Sports Med (2007) 1.78

Community psychiatric nurse teams: intensive support versus generic care. Br J Psychiatry (1994) 1.77

Disseminated cysticercosis. Indian Pediatr (1996) 1.76

Underuse of cardiac procedures: do women, ethnic minorities, and the uninsured fail to receive needed revascularization? Ann Intern Med (1999) 1.76

The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology (2000) 1.76

Preoperative multimodal analgesia facilitates recovery after ambulatory laparoscopic cholecystectomy. Anesth Analg (1996) 1.74

Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nat Genet (1996) 1.74

The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol Cell Biol (1995) 1.71

Visualization and mechanical manipulations of individual fibrin fibers suggest that fiber cross section has fractal dimension 1.3. Biophys J (2004) 1.71

Adverse events with extended wear of disposable hydrogels: results for the first 13 months of lens wear. Ophthalmology (1999) 1.70

Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli. J Bacteriol (1997) 1.69

Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors. Ann Oncol (2009) 1.68

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem (2000) 1.68

Current perspectives in infectious keratitis. Indian J Ophthalmol (1994) 1.67

Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia. Arthritis Rheum (2001) 1.67

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Aetiology of sudden cardiac death in athletes in the United Kingdom: a pathological study. Heart (2009) 1.66

Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial. Ann Oncol (2008) 1.66

Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart (2000) 1.66

Molecular epidemiology of a large outbreak of hepatitis B linked to autohaemotherapy. Lancet (2000) 1.66

Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes. Circulation (2010) 1.64

Aneurysmal cyst of soft tissue: report of a case with serial magnetic resonance imaging and biopsy. Hum Pathol (1997) 1.63

Utility values and diabetic retinopathy. Am J Ophthalmol (1999) 1.63

Recent advances in the molecular pathogenesis of Ewing's sarcoma. Oncogene (2010) 1.62