EWS and RE1-Silencing Transcription Factor Inhibit Neuronal Phenotype Development and Oncogenic Transformation in Ewing Sarcoma.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3782006)

Published in Genes Cancer on May 01, 2013

Authors

Savita Sankar1, Nicholas C Gomez, Russell Bell, Mukund Patel, Ian J Davis, Stephen L Lessnick, Wen Luo

Author Affiliations

1: Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

Long noncoding RNA as modular scaffold of histone modification complexes. Science (2010) 15.23

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature (2008) 7.18

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83

A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell (2006) 3.29

Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A (1996) 3.11

ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions. Genome Biol (2011) 2.47

A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J Neurosci (2007) 2.45

TLS, EWS and TAF15: a model for transcriptional integration of gene expression. Brief Funct Genomic Proteomic (2006) 2.29

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell (2002) 2.28

Small CTD phosphatases function in silencing neuronal gene expression. Science (2005) 2.23

Chromosome translocation in peripheral neuroepithelioma. N Engl J Med (1984) 2.22

Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron (1999) 2.15

The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci (2011) 1.87

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res (2006) 1.80

Gene set enrichment analysis made simple. Stat Methods Med Res (2009) 1.79

EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol Cell Biol (1998) 1.71

Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am J Pathol (1987) 1.68

Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet (1984) 1.65

Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity. J Neurosci (2003) 1.64

Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene. Oncogene (1995) 1.51

REST in good times and bad: roles in tumor suppressor and oncogenic activities. Cell Cycle (2006) 1.51

Desmoplastic small round cell tumor: I: a histopathologic study of 39 cases with emphasis on unusual histological patterns. Am J Surg Pathol (1998) 1.50

EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res (2005) 1.46

Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer. Proc Natl Acad Sci U S A (2008) 1.43

Translocation involving chromosome 22 in Ewing's sarcoma. A cytogenetic study of four fresh tumors. Cancer Genet Cytogenet (1984) 1.42

Cotranscriptional exon skipping in the genotoxic stress response. Nat Struct Mol Biol (2010) 1.39

Many human medulloblastoma tumors overexpress repressor element-1 silencing transcription (REST)/neuron-restrictive silencer factor, which can be functionally countered by REST-VP16. Mol Cancer Ther (2005) 1.37

The Ewing sarcoma protein regulates DNA damage-induced alternative splicing. Mol Cell (2011) 1.33

EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicing. J Biol Chem (2000) 1.33

A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res (2000) 1.31

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription. Genome Res (2011) 1.29

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development (2009) 1.25

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Oncogene (2012) 1.20

GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene (2009) 1.20

The transcription factor REST is lost in aggressive breast cancer. PLoS Genet (2010) 1.17

Regulation of non-coding RNA networks in the nervous system--what's the REST of the story? Neurosci Lett (2009) 1.16

Reduced expression of the neuron restrictive silencer factor permits transcription of glycine receptor alpha1 subunit in small-cell lung cancer cells. Oncogene (2003) 1.15

CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. J Clin Invest (2010) 1.10

MotifMap: integrative genome-wide maps of regulatory motif sites for model species. BMC Bioinformatics (2011) 1.10

Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation. Histopathology (2001) 1.06

Characterization of neural cell adhesion molecules (NCAM) expressed by Ewing and neuroblastoma cell lines. Int J Cancer (1987) 1.05

EWS/ETS fusion genes induce epithelial and neuroectodermal differentiation in NIH 3T3 fibroblasts. Lab Invest (1999) 1.03

Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. Oncogene (2003) 1.00

Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS. J Neurosci (1997) 1.00

Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues. Bioessays (1999) 0.97

Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines. Cancer Res (2009) 0.93

SCG3 transcript in peripheral blood is a prognostic biomarker for REST-deficient small cell lung cancer. Clin Cancer Res (2009) 0.89

Elevated serum chromogranin A is detectable in patients with carcinomas at advanced disease stages. Ann Clin Lab Sci (2000) 0.88

IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. Cell Signal (2005) 0.87

PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma. Cancer Res (2012) 0.87

Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains. Genomics (1997) 0.86

The EWS protein is dispensable for Ewing tumor growth. Cancer Res (2001) 0.83

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions. PLoS One (2012) 0.82

A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. Int J Biol Markers (2010) 0.80

The pro-oncoprotein EWS (Ewing's Sarcoma protein) interacts with the Brn-3a POU transcription factor and inhibits its ability to activate transcription. Cancer Biol Ther (2002) 0.80

Dysregulated expression of secretogranin III is involved in neurotoxin-induced dopaminergic neuron apoptosis. J Neurosci Res (2012) 0.78

Chromogranin A--serum marker for prostate cancer. J Pak Med Assoc (2011) 0.78

Articles by these authors

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

A protein interaction network of the malaria parasite Plasmodium falciparum. Nature (2005) 3.81

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell (2006) 3.29

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell (2003) 3.23

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature (2007) 3.21

A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell (2007) 2.83

Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS Genet (2007) 2.77

Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes. Genome Res (2007) 2.67

A human MAP kinase interactome. Nat Methods (2010) 2.62

Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer (2009) 2.26

Microsatellites as EWS/FLI response elements in Ewing's sarcoma. Proc Natl Acad Sci U S A (2008) 2.06

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol (2002) 2.00

TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res (2007) 1.93

Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA. Nat Protoc (2012) 1.84

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med (2007) 1.82

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res (2006) 1.80

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79

Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer (2008) 1.66

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle (2007) 1.66

Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol (2010) 1.65

Calibration of multiple in silico tools for predicting pathogenicity of mismatch repair gene missense substitutions. Hum Mutat (2012) 1.61

The theory of planned behavior and healthy eating. Health Psychol (2002) 1.61

Teacher-Student Support, Effortful Engagement, and Achievement: A 3-Year Longitudinal Study. J Educ Psychol (2008) 1.60

State of the science: an update on renal cell carcinoma. Mol Cancer Res (2012) 1.58

Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol (2005) 1.54

The canine oral microbiome. PLoS One (2012) 1.44

Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer (2014) 1.43

A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. J Biol Chem (2003) 1.42

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One (2008) 1.41

Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell (2006) 1.41

Promiscuous partnerships in Ewing's sarcoma. Cancer Genet (2011) 1.41

Sumoylation of MITF and its related family members TFE3 and TFEB. J Biol Chem (2004) 1.40

Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor-associated tumors: results of a multicenter phase 2 trial. Cancer (2012) 1.36

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Genome Res (2013) 1.31

Regulation of neurotoxin production and sporulation by a Putative agrBD signaling system in proteolytic Clostridium botulinum. Appl Environ Microbiol (2010) 1.30

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription. Genome Res (2011) 1.29

Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle (2006) 1.27

Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. J Biol Chem (2005) 1.24

Analyzing Longitudinal Data with Multilevel Models: An Example with Individuals Living with Lower Extremity Intra-articular Fractures. Rehabil Psychol (2008) 1.17

EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Cancer Res (2009) 1.17

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle (2006) 1.14

NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene. J Biol Chem (2006) 1.13

Altering biomineralization by protein design. J Biol Chem (2006) 1.12

Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem (2006) 1.10

CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. J Clin Invest (2010) 1.10

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J Biol Chem (2010) 1.10

Interaction of an atypical Plasmodium falciparum ETRAMP with human apolipoproteins. Malar J (2008) 1.09

A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem (2003) 1.07

Inhibition of the met receptor in mesothelioma. Clin Cancer Res (2005) 1.05

Role of resilient personality on lower achieving first grade students' current and future achievement. J Sch Psychol (2007) 1.04

Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem (2010) 1.04

Functional domains for amelogenin revealed by compound genetic defects. J Bone Miner Res (2003) 1.03

The Ste20 kinase MST4 plays a role in prostate cancer progression. Cancer Res (2003) 1.03

Validation of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinomas. Diagn Mol Pathol (2011) 1.01

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. J Biol Chem (2004) 0.99

Enamel structure properties controlled by engineered proteins in transgenic mice. J Bone Miner Res (2003) 0.99

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma. Genes Cancer (2010) 0.98

Detection of point mutations of the Axin1 gene in colorectal cancers. Int J Cancer (2003) 0.98

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure. Cell Cycle (2008) 0.98

Overexpression of TRAP in the enamel matrix does not alter the enamel structural hierarchy. Cells Tissues Organs (2004) 0.97

The behavioral activation for depression scale-short form: development and validation. Behav Ther (2011) 0.97

Contrast enhanced ultrasound of hepatocellular carcinoma. World J Radiol (2010) 0.97

A Decade in Banking Ewing Sarcoma: A Report from the Children's Oncology Group. Front Oncol (2013) 0.97

EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer Res (2007) 0.95

Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens. BMC Genomics (2012) 0.95

EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations. Cancer Genet (2012) 0.94

Characterization of the ends and target site of a novel tetracycline resistance-encoding conjugative transposon from Enterococcus faecium 664.1H1. J Bacteriol (2006) 0.93

Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling. J Cell Biol (2013) 0.93

Reversal of multidrug resistance in gastric cancer cells by E2F-1 downregulation in vitro and in vivo. J Cell Biochem (2014) 0.92

Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation. World J Gastroenterol (2013) 0.90

Biomarkers in Ewing Sarcoma: The Promise and Challenge of Personalized Medicine. A Report from the Children's Oncology Group. Front Oncol (2013) 0.90

Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken) (2008) 0.89

Hemostasis of active bleeding from the liver with percutaneous microwave coagulation therapy under contrast-enhanced ultrasonographic guidance: an experimental study. J Ultrasound Med (2008) 0.89

A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol (2013) 0.89

Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12. J Bacteriol (2002) 0.88

The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer (2012) 0.88

Array comparative hybridisation reveals a high degree of similarity between UK and European clinical isolates of hypervirulent Clostridium difficile. BMC Genomics (2010) 0.88

The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus. J Virol (2013) 0.87

Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. Cancer Genet (2012) 0.87

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a. ChemMedChem (2014) 0.86

Staphylococcus aureus ST6-t701 isolates from food-poisoning outbreaks (2006-2013) in Xi'an, China. Foodborne Pathog Dis (2015) 0.86

A simplified genetic design for mammalian enamel. Biomaterials (2011) 0.86

Improved ChIP-chip analysis by a mixture model approach. BMC Bioinformatics (2009) 0.85

FAVR (Filtering and Annotation of Variants that are Rare): methods to facilitate the analysis of rare germline genetic variants from massively parallel sequencing datasets. BMC Bioinformatics (2013) 0.85

A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease. J Biol Chem (2014) 0.84

Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. Sarcoma (2010) 0.84

EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. Clin Cancer Res (2012) 0.84

Antibody detection of translocations in Ewing sarcoma. EMBO Mol Med (2012) 0.84

Glutathione s-transferases in pediatric cancer. Front Oncol (2011) 0.84

Photo-responsive carbon nanomaterials functionalized by azobenzene moieties: structures, properties and application. Nanoscale (2012) 0.84

A detailed protocol for formaldehyde-assisted isolation of regulatory elements (FAIRE). Curr Protoc Mol Biol (2013) 0.84

Downregulation of NDRG1 promotes invasion of human gastric cancer AGS cells through MMP-2. Tumour Biol (2010) 0.83