Published in Br J Pharmacol on April 01, 2013
Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update. J Med Chem (2013) 0.86
MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol (2015) 0.83
Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1. Immunology (2015) 0.78
Gambogic Acid Disrupts Toll-like Receptor4 Activation by Blocking Lipopolysaccharides Binding to Myeloid Differentiation Factor 2. Toxicol Res (2015) 0.78
Kdo2 -lipid A: structural diversity and impact on immunopharmacology. Biol Rev Camb Philos Soc (2014) 0.78
Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms. Mol Med Rep (2015) 0.77
Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury. Sci Rep (2016) 0.76
Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. Sci Rep (2016) 0.75
X-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes. Mol Cancer (2015) 0.75
Caffeic acid phenetyl ester and its ability to prevent viral infection - Some comments. J Intercult Ethnopharmacol (2016) 0.75
Targeting myeloid differentiation protein 2 by the new chalcone L2H21 protects LPS-induced acute lung injury. J Cell Mol Med (2016) 0.75
Pathogen recognition and innate immunity. Cell (2006) 44.14
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol (2010) 17.30
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature (2009) 8.99
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell (2007) 6.84
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med (2007) 4.39
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A (1996) 4.11
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med (2001) 1.95
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int Immunol (2004) 1.91
Roles for accessory molecules in microbial recognition by Toll-like receptors. J Endotoxin Res (2006) 1.59
Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol (2003) 1.54
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res (1999) 1.54
The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Mol Cells (2006) 1.39
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol (2010) 1.39
Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol (2004) 1.33
MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukoc Biol (2007) 1.26
Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. Eur J Pharmacol (2010) 1.25
Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism. J Biol Chem (2003) 1.23
Toll-like receptors as targets for immune disorders. Trends Pharmacol Sci (2011) 1.17
Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. Int J Biochem Cell Biol (2008) 1.14
The role of disulfide bonds in the assembly and function of MD-2. Proc Natl Acad Sci U S A (2003) 1.14
Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res (1993) 1.13
Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. J Immunol (2009) 1.08
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol (2009) 1.00
Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem (2009) 0.93
Anti-inflammatory effects of caffeic acid phenethyl ester (CAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils. Int J Cancer (2009) 0.93
The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells. BMC Immunol (2009) 0.86
Effects of caffeic acid phenethyl ester on lipopolysaccharide-induced lung injury in rats. Pulm Pharmacol Ther (2005) 0.82
Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2009. Cancer Res Treat (2012) 5.07
Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat (2011) 4.21
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nat Genet (2012) 2.92
FTFD: an informatics pipeline supporting phylogenomic analysis of fungal transcription factors. Bioinformatics (2008) 1.79
Prediction of cancer incidence and mortality in Korea, 2012. Cancer Res Treat (2012) 1.75
Identification of aldo-keto reductases as NRF2-target marker genes in human cells. Toxicol Lett (2013) 1.60
Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008. Korean J Hematol (2012) 1.56
Fungal cytochrome P450 database. BMC Genomics (2008) 1.48
The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem (2005) 1.44
Systematic and searchable classification of cytochrome P450 proteins encoded by fungal and oomycete genomes. BMC Genomics (2012) 1.41
CFGP: a web-based, comparative fungal genomics platform. Nucleic Acids Res (2007) 1.39
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol (2010) 1.39
Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol (2004) 1.38
Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes. Arterioscler Thromb Vasc Biol (2006) 1.26
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology (2009) 1.20
A proteomics approach to identify the ubiquitinated proteins in mouse heart. Biochem Biophys Res Commun (2007) 1.18
Peroxiredoxin-I is an autoimmunogenic tumor antigen in non-small cell lung cancer. FEBS Lett (2005) 1.12
Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Thromb Res (2009) 1.11
Erythrophagocytosis of lead-exposed erythrocytes by renal tubular cells: possible role in lead-induced nephrotoxicity. Environ Health Perspect (2014) 1.09
Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. J Immunol (2009) 1.08
Prediction of cancer incidence and mortality in Korea, 2011. Cancer Res Treat (2011) 1.06
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS One (2010) 1.06
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells. Mol Cell (2011) 1.05
Low level of lead can induce phosphatidylserine exposure and erythrophagocytosis: a new mechanism underlying lead-associated anemia. Toxicol Sci (2011) 1.02
End-of-life care in long-term care settings for older people: a literature review. Int J Older People Nurs (2006) 1.02
Non-constraining sleep/wake monitoring system using bed actigraphy. Med Biol Eng Comput (2006) 1.02
Peptidoglycan recognition proteins involved in 1,3-beta-D-glucan-dependent prophenoloxidase activation system of insect. J Biol Chem (2003) 1.01
TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J Dermatol Sci (2010) 1.01
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol (2009) 1.00
Development of an off-line capillary column IMAC phosphopeptide enrichment method for label-free phosphorylation relative quantification. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.99
Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1. J Cell Biochem (2007) 0.98
Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med J (2011) 0.98
Arrest defective 1 autoacetylation is a critical step in its ability to stimulate cancer cell proliferation. Cancer Res (2010) 0.97
Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. J Pharm Biomed Anal (2009) 0.97
Comprehensive proteome analysis of lettuce latex using multidimensional protein-identification technology. Phytochemistry (2009) 0.95
Plasmodesmal receptor-like kinases identified through analysis of rice cell wall extracted proteins. Protoplasma (2010) 0.95
In-depth insight into in vivo apoplastic secretome of rice-Magnaporthe oryzae interaction. J Proteomics (2012) 0.94
Comparison of conventional, nested, and real-time quantitative PCR for diagnosis of scrub typhus. J Clin Microbiol (2010) 0.94
High-throughput screening (HTS) of anticancer drug efficacy on a micropillar/microwell chip platform. Anal Chem (2013) 0.94
Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway. J Cell Biochem (2009) 0.93
fPoxDB: fungal peroxidase database for comparative genomics. BMC Microbiol (2014) 0.93
SNUGB: a versatile genome browser supporting comparative and functional fungal genomics. BMC Genomics (2008) 0.92
Carnosic acid, a phenolic diterpene from rosemary, prevents UV-induced expression of matrix metalloproteinases in human skin fibroblasts and keratinocytes. Exp Dermatol (2013) 0.92
PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. Mol Carcinog (2014) 0.92
Global expression profiling of transcription factor genes provides new insights into pathogenicity and stress responses in the rice blast fungus. PLoS Pathog (2013) 0.92
Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model. J Invest Dermatol (2011) 0.90
Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair. J Biol Chem (2010) 0.90
Fungal plant cell wall-degrading enzyme database: a platform for comparative and evolutionary genomics in fungi and Oomycetes. BMC Genomics (2013) 0.89
Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/β-Catenin complexes in adherens junctions. Cancer Res (2013) 0.89
Genome-scale analysis of ABC transporter genes and characterization of the ABCC type transporter genes in Magnaporthe oryzae. Genomics (2013) 0.88
Secretome analysis of the rice bacterium Xanthomonas oryzae (Xoo) using in vitro and in planta systems. Proteomics (2013) 0.88
PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress. Biochem Biophys Res Commun (2012) 0.88
MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity. J Infect Dis (2011) 0.88
Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models. J Invest Dermatol (2011) 0.88
Post-translational modification of crystallins in vitreous body from experimental autoimmune uveitis of rats. J Proteome Res (2007) 0.87
Cyber infrastructure for Fusarium: three integrated platforms supporting strain identification, phylogenetics, comparative genomics and knowledge sharing. Nucleic Acids Res (2010) 0.87
Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2. Biochem Biophys Res Commun (2013) 0.87
The effect of epidermal growth factor (EGF) conjugated with low-molecular-weight protamine (LMWP) on wound healing of the skin. Biomaterials (2012) 0.87
Extraction behavior of As, Pb, and Zn from mine tailings with acid and base solutions. J Hazard Mater (2009) 0.87
Comparison of the microbiological and chemical characterization of harvested rainwater and reservoir water as alternative water resources. Sci Total Environ (2009) 0.86
Black soybean extract can attenuate thrombosis through inhibition of collagen-induced platelet activation. J Nutr Biochem (2010) 0.86
Determination of spatial distribution of melamine-cyanuric acid crystals in rat kidney tissue by histology and imaging matrix-assisted laser desorption/ionization quadrupole time-of-flight mass spectrometry. Chem Res Toxicol (2010) 0.86
Vascular smooth muscle dysfunction and remodeling induced by ginsenoside Rg3, a bioactive component of ginseng. Toxicol Sci (2010) 0.86
Expression of heat shock protein 60 kDa is upregulated in cervical cancer. Yonsei Med J (2009) 0.86
Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period. Psychopharmacology (Berl) (2006) 0.86
A new 3D reconstituted human corneal epithelium model as an alternative method for the eye irritation test. Toxicol In Vitro (2010) 0.86
Proteomic analysis of the secretome of rice calli. Physiol Plant (2009) 0.86
Identification of crystallin family proteins in vitreous body in rat endotoxin-induced uveitis: Involvement of crystallin truncation in uveitis pathogenesis. Proteomics (2006) 0.85
Characterization of 2-octenoyl-CoA carboxylase/reductase utilizing pteB from Streptomyce avermitilis. Biosci Biotechnol Biochem (2011) 0.85
Vascular smooth muscle dysfunction induced by monomethylarsonous acid (MMA III): a contributing factor to arsenic-associated cardiovascular diseases. Environ Res (2008) 0.85
Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization. Chem Biol Interact (2009) 0.85
Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity. Nanotoxicology (2010) 0.85
IMGD: an integrated platform supporting comparative genomics and phylogenetics of insect mitochondrial genomes. BMC Genomics (2009) 0.84
Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure. Toxicol Appl Pharmacol (2009) 0.84
Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses. Mediators Inflamm (2010) 0.84
Selenium suppresses the activation of transcription factor NF-kappa B and IRF3 induced by TLR3 or TLR4 agonists. Int Immunopharmacol (2008) 0.84
Delineation of the role of glycosylation in the cytotoxic properties of quercetin using novel assays in living vertebrates. J Nat Prod (2014) 0.84
Inhibition of sulfide mineral oxidation by surface coating agents: batch and field studies. J Hazard Mater (2012) 0.84
Procoagulant and prothrombotic activation of human erythrocytes by phosphatidic acid. Am J Physiol Heart Circ Physiol (2010) 0.83
A naphthoquinone derivative can induce anemia through phosphatidylserine exposure-mediated erythrophagocytosis. J Pharmacol Exp Ther (2010) 0.83
A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression. Exp Dermatol (2013) 0.83
C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. J Mol Biol (2009) 0.83
2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food (2012) 0.82
[C-reactive protein and carotid intima-media thickness in a population of middle-aged Koreans]. J Prev Med Public Health (2009) 0.82
Inorganic arsenite potentiates vasoconstriction through calcium sensitization in vascular smooth muscle. Environ Health Perspect (2005) 0.81
Comparison of flow cytometry and immunohistochemistry in non-radioisotopic murine lymph node assay using bromodeoxyuridine. Toxicol Lett (2009) 0.81
Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2. Inflamm Res (2013) 0.81
Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization. Circulation (2013) 0.81
Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation. J Invest Dermatol (2012) 0.81
Toll-like receptor 4-mediated immunoregulation by the aqueous extract of Mori Fructus. Phytother Res (2009) 0.81
The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. Biochem Biophys Res Commun (2012) 0.81
Doxorubicin-induced platelet procoagulant activities: an important clue for chemotherapy-associated thrombosis. Toxicol Sci (2011) 0.81