Published in Toxicol Lett on January 07, 2013
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease. Redox Biol (2013) 1.04
The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxid Med Cell Longev (2015) 0.97
Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation. Diabetes (2013) 0.87
A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity. Toxins (Basel) (2014) 0.86
Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells. Oncotarget (2015) 0.83
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway. Oncotarget (2016) 0.83
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. Toxicol Sci (2015) 0.81
Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. Oxid Med Cell Longev (2013) 0.80
Inhibitory role of the KEAP1-NRF2 pathway in TGFβ1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling. PLoS One (2014) 0.80
NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages. PLoS One (2015) 0.79
Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder. Free Radic Biol Med (2015) 0.79
Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression. Horm Cancer (2016) 0.78
Ado-Keto Reductase Regulation by the Nrf2-System: Implications for Stress Response, Chemotherapy Drug Resistance and Carcinogenesis. Chem Res Toxicol (2016) 0.75
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer. Br J Cancer (2016) 0.75
Overexpression of DJ-1 reduces oxidative stress and attenuates hypoxia/reoxygenation injury in NRK-52E cells exposed to high glucose. Int J Mol Med (2016) 0.75
Nrf2 inducibility of aldo-keto reductases. Toxicol Lett (2013) 0.75
Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis. Sci Rep (2016) 0.75
Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro. Lipids Health Dis (2016) 0.75
Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death. Sci Rep (2017) 0.75
Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2009. Cancer Res Treat (2012) 5.07
Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat (2011) 4.21
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res (2006) 2.05
Prediction of cancer incidence and mortality in Korea, 2012. Cancer Res Treat (2012) 1.75
Statistics of hematologic malignancies in Korea: incidence, prevalence and survival rates from 1999 to 2008. Korean J Hematol (2012) 1.56
Suppression of Nrf2 signaling by angiotensin II in murine renal epithelial cells. Arch Pharm Res (2011) 1.55
The Nrf2 system as a potential target for the development of indirect antioxidants. Molecules (2010) 1.54
Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal (2010) 1.50
Investigation of T2-weighted signal intensity of infarcted myocardium and its correlation with delayed enhancement magnetic resonance imaging in a porcine model with reperfused acute myocardial infarction. Int J Cardiovasc Imaging (2009) 1.49
Local-scale patterns of genetic variability, outcrossing, and spatial structure in natural stands of Arabidopsis thaliana. PLoS Genet (2010) 1.45
NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res (2011) 1.41
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol (2010) 1.39
Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance. Cancer Lett (2007) 1.38
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes. Proc Natl Acad Sci U S A (2009) 1.36
Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. Eur J Pharmacol (2010) 1.25
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. J Biol Chem (2004) 1.21
Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway. Free Radic Biol Med (2009) 1.21
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology (2009) 1.20
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med (2010) 1.12
Cellular uptake mechanism of an inorganic nanovehicle and its drug conjugates: Enhanced efficacy due to clathrin-mediated endocytosis. Bioconjug Chem (2006) 1.11
The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. J Biol Chem (2004) 1.10
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem (2009) 1.09
Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. J Immunol (2009) 1.08
Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation. Mol Cell Biochem (2008) 1.08
Prediction of cancer incidence and mortality in Korea, 2011. Cancer Res Treat (2011) 1.06
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS One (2010) 1.06
Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells. Mol Cell (2011) 1.05
Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2. Br J Pharmacol (2013) 1.02
Non-constraining sleep/wake monitoring system using bed actigraphy. Med Biol Eng Comput (2006) 1.02
Peptidoglycan recognition proteins involved in 1,3-beta-D-glucan-dependent prophenoloxidase activation system of insect. J Biol Chem (2003) 1.01
Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol (2009) 1.00
Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death. Exp Mol Med (2007) 0.99
Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol (2007) 0.98
Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med J (2011) 0.98
Comparison of conventional, nested, and real-time quantitative PCR for diagnosis of scrub typhus. J Clin Microbiol (2010) 0.94
PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. Mol Carcinog (2014) 0.92
Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Arch Biochem Biophys (2011) 0.91
Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells. Toxicol Appl Pharmacol (2012) 0.90
Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair. J Biol Chem (2010) 0.90
Peroxiredoxin-2 represses melanoma metastasis by increasing E-Cadherin/β-Catenin complexes in adherens junctions. Cancer Res (2013) 0.89
Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity. Toxicol Appl Pharmacol (2011) 0.89
Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway. Biochem Pharmacol (2008) 0.89
Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner. J Pharmacol Exp Ther (2008) 0.88
MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity. J Infect Dis (2011) 0.88
PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress. Biochem Biophys Res Commun (2012) 0.88
NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity. Free Radic Biol Med (2012) 0.87
Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation. Free Radic Biol Med (2013) 0.87
Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2. Biochem Biophys Res Commun (2013) 0.87
Long-term neuroprotective effect of postischemic hypothermia in a neonatal rat model of severe hypoxic ischemic encephalopathy: a comparative study on the duration and depth of hypothermia. Pediatr Res (2010) 0.87
Involvement of Nrf2-GSH signaling in TGFβ1-stimulated epithelial-to-mesenchymal transition changes in rat renal tubular cells. Arch Pharm Res (2014) 0.86
Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period. Psychopharmacology (Berl) (2006) 0.86
Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. Arch Pharm Res (2008) 0.86
Expression of heat shock protein 60 kDa is upregulated in cervical cancer. Yonsei Med J (2009) 0.86
Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. Molecules (2011) 0.86
Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization. Chem Biol Interact (2009) 0.85
Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome. Arch Pharm Res (2009) 0.85
Chloroquine-induced nitric oxide increase and cell death is dependent on cellular GSH depletion in A172 human glioblastoma cells. Toxicol Lett (2008) 0.84
Phase 2 enzyme induction by the major metabolite of oltipraz. Chem Res Toxicol (2003) 0.84
Selenium suppresses the activation of transcription factor NF-kappa B and IRF3 induced by TLR3 or TLR4 agonists. Int Immunopharmacol (2008) 0.84
Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses. Mediators Inflamm (2010) 0.84
Analysis of differential plaque depositions in the brains of Tg2576 and Tg-APPswe/PS1dE9 transgenic mouse models of Alzheimer disease. Exp Mol Med (2012) 0.83
G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation. Carcinogenesis (2010) 0.82
Allogeneic renal graft rejection in a rat model: in vivo MR imaging of the homing trait of macrophages. Radiology (2010) 0.82
[C-reactive protein and carotid intima-media thickness in a population of middle-aged Koreans]. J Prev Med Public Health (2009) 0.82
2,5-dihydroxyacetophenone isolated from Rehmanniae Radix Preparata inhibits inflammatory responses in lipopolysaccharide-stimulated RAW264.7 macrophages. J Med Food (2012) 0.82
Toll-like receptor 4-mediated immunoregulation by the aqueous extract of Mori Fructus. Phytother Res (2009) 0.81
Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization. Circulation (2013) 0.81
Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2. Inflamm Res (2013) 0.81
N-Methyl-D-aspartate receptor-mediated chemotaxis and Ca(2+) signaling in Tetrahymena pyriformis. Protist (2009) 0.81
Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator. J Pharm Pharmacol (2008) 0.80
Enhanced 4-hydroxynonenal resistance in KEAP1 silenced human colon cancer cells. Oxid Med Cell Longev (2013) 0.80
Suppression of skin inflammation in keratinocytes and acute/chronic disease models by caffeic acid phenethyl ester. Arch Dermatol Res (2014) 0.80
Anti-inflammatory action of mollugin and its synthetic derivatives in HT-29 human colonic epithelial cells is mediated through inhibition of NF-kappaB activation. Eur J Pharmacol (2009) 0.80
Supraumbilical skin rash after transcatheter arterial chemoembolization: successful treatment with pentoxifylline. J Dermatol (2011) 0.80
Pace of macrophage recruitment during different stages of soft tissue infection: semi-quantitative evaluation by in vivo magnetic resonance imaging. Eur Radiol (2008) 0.80
A new online technique for the simultaneous measurement of the δ13C value of dissolved inorganic carbon and the δ18O value of water from a single solution sample using continuous-flow isotope ratio mass spectrometry. Rapid Commun Mass Spectrom (2014) 0.80
N(omega)-nitro-L-arginine methyl ester attenuates lithium-induced c-Fos, but not conditioned taste aversion, in rats. Neurosci Res (2004) 0.80
Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10. BMB Rep (2010) 0.80
Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. Biol Pharm Bull (2008) 0.80
Association between blood pressure and carotid intima-media thickness. J Pediatr (2008) 0.80
Silver nanoparticles-mediated G2/M cycle arrest of renal epithelial cells is associated with NRF2-GSH signaling. Toxicol Lett (2012) 0.79
Refeeding-induced expression of neuronal nitric oxide synthase in the rat paraventricular nucleus. Brain Res (2005) 0.79
Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells. BMC Complement Altern Med (2014) 0.79
Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners. Inflammation (2013) 0.79
Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production. Evid Based Complement Alternat Med (2013) 0.79
Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4. Mol Cells (2008) 0.78
Subcutaneous panniculitis-like T-cell lymphoma: successful treatment with systemic steroid alone. J Dermatol (2011) 0.78
RU486 blocks fasting-induced decrease of neuronal nitric oxide synthase in the rat paraventricular nucleus. Brain Res (2004) 0.78
Toll-like receptor 4/nuclear factor-κB signaling pathway is involved in ACTG-toxin H-mediated anti-inflammatory effect. Mol Cell Biochem (2012) 0.78
Stress-responsive hypothalamic-nucleus accumbens regulation may vary depending on stressors. Indian J Exp Biol (2012) 0.78
1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP. Eur J Pharmacol (2007) 0.78
Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1. Immunology (2015) 0.78
The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling. Vascul Pharmacol (2008) 0.78
In vivo fluorescence imaging of bacteriogenic cyanide in the lungs of live mice infected with cystic fibrosis pathogens. PLoS One (2011) 0.77
Predictive factors of malignancy in thyroid nodules with a cytological diagnosis of follicular neoplasm. Endocr Pathol (2013) 0.77
Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells. Biochem Pharmacol (2010) 0.77