Published in Exp Eye Res on December 08, 2012
Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci (2013) 1.17
Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016). Exp Eye Res (2013) 1.11
Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS One (2013) 1.06
Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci (2016) 0.97
The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet (2014) 0.88
Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflammation (2014) 0.80
Evaluating Potential Therapies in a Mouse Model of Focal Retinal Degeneration with Age-related Macular Degeneration (AMD)-Like Lesions. J Clin Exp Ophthalmol (2013) 0.79
Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice. Redox Biol (2017) 0.79
Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) mice. J Neuroinflammation (2015) 0.78
The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype. Am J Pathol (2016) 0.76
A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice. Invest Ophthalmol Vis Sci (2015) 0.76
Fractalkine signaling in regulation of insulin secretion. Islets (2014) 0.75
Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS One (2017) 0.75
Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD. Biochem Biophys Res Commun (2016) 0.75
Reply to comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80-87). Exp Eye Res (2013) 0.75
MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc (2016) 0.75
Comprehensive analysis of mouse retinal mononuclear phagocytes. Nat Protoc (2017) 0.75
NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41
Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 14.74
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (2005) 14.43
Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med (2007) 11.51
Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science (2007) 9.54
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol (2009) 8.67
Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest (1997) 7.58
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med (2003) 6.61
Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med (1998) 6.52
Migratory fate and differentiation of blood monocyte subsets. Immunobiology (2006) 4.30
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest (2007) 3.39
Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71
Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 2.36
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc Natl Acad Sci U S A (2007) 2.20
Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice. Aging Cell (2007) 1.93
The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci (2009) 1.84
Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults. BMC Immunol (2010) 1.78
Monocytes: subsets, origins, fates and functions. Curr Opin Hematol (2010) 1.77
A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitro. J Immunol (1995) 1.47
The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration. PLoS One (2008) 1.44
Light-induced migration of retinal microglia into the subretinal space. Invest Ophthalmol Vis Sci (2001) 1.44
Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Invest Ophthalmol Vis Sci (2009) 1.34
Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model. Concomitant regulation by MHC and non-MHC genes. J Immunol (1992) 1.24
In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye. Invest Ophthalmol Vis Sci (2008) 1.22
Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS One (2012) 1.19
Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. Arch Ophthalmol (2010) 1.16
Dendritic cells and macrophages in the uveal tract of the normal mouse eye. Br J Ophthalmol (1999) 1.16
CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2. Microvasc Res (2005) 1.15
Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice. Ophthalmic Res (2008) 1.14
Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One (2011) 1.14
Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1. Neurobiol Aging (2011) 1.08
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. J Neurosci (2002) 1.08
Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration. J Neuroinflammation (2012) 0.98
In vivo observation of the locomotion of microglial cells in the retina. Glia (2010) 0.94
Five recombinant simian immunodeficiency virus pseudotypes lead to exclusive transduction of retinal pigmented epithelium in rat. Mol Ther (2002) 0.93
Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet (2004) 5.43
Effective gene therapy with nonintegrating lentiviral vectors. Nat Med (2006) 2.70
Long-term effect of gene therapy on Leber's congenital amaurosis. N Engl J Med (2015) 2.68
The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation. J Cell Sci (2002) 2.65
Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med (2009) 2.19
Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci (2005) 2.02
In vitro characterization of a spontaneously immortalized human Müller cell line (MIO-M1). Invest Ophthalmol Vis Sci (2002) 1.89
The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Invest Ophthalmol Vis Sci (2009) 1.84
Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci U S A (2012) 1.79
Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Hum Mol Genet (2009) 1.76
Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency. Hum Gene Ther (2011) 1.68
Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol Cell Biol (2006) 1.65
Evolution and spectral tuning of visual pigments in birds and mammals. Philos Trans R Soc Lond B Biol Sci (2009) 1.56
Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells (2012) 1.52
Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy. Hum Mol Genet (2011) 1.47
Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Invest Ophthalmol Vis Sci (2005) 1.47
Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Ophthalmology (2007) 1.44
AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter. Invest Ophthalmol Vis Sci (2007) 1.44
Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells (2010) 1.42
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. Am J Hum Genet (2007) 1.33
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood (2004) 1.30
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa. Mol Ther (2003) 1.26
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. PLoS One (2010) 1.24
Topographical characterization of cone photoreceptors and the area centralis of the canine retina. Mol Vis (2008) 1.23
Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans. Am J Hum Genet (2006) 1.22
Prospects for retinal gene replacement therapy. Trends Genet (2009) 1.20
Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. PLoS One (2012) 1.19
The influence of ontogeny and light environment on the expression of visual pigment opsins in the retina of the black bream, Acanthopagrus butcheri. J Exp Biol (2008) 1.19
Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye. Stem Cells (2007) 1.17
Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells (2010) 1.13
In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Mol Ther (2006) 1.13
Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy. J Gene Med (2003) 1.12
Brief report: self-organizing neuroepithelium from human pluripotent stem cells facilitates derivation of photoreceptors. Stem Cells (2013) 1.11
Acute corneal calcification following chemical injury. Cornea (2005) 1.07
Real-time in vivo imaging of retinal cell apoptosis after laser exposure. Invest Ophthalmol Vis Sci (2008) 1.06
Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther (2011) 1.06
Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer. J Gene Med (2004) 1.05
Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice. J Gene Med (2009) 1.04
Spectral tuning of shortwave-sensitive visual pigments in vertebrates. Photochem Photobiol (2007) 1.01
Functional characterization, tuning, and regulation of visual pigment gene expression in an anadromous lamprey. FASEB J (2007) 1.01
Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle. Curr Biol (2006) 1.00
Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography. PLoS One (2013) 0.99
The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice. PLoS One (2010) 0.99
Subconjunctival bevacizumab induces regression of corneal neovascularisation: a pilot randomised placebo-controlled double-masked trial. Br J Ophthalmol (2012) 0.98
Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Mol Ther (2005) 0.97
"Cone dystrophy with supernormal rod electroretinogram": a comprehensive genotype/phenotype study including fundus autofluorescence and extensive electrophysiology. Retina (2010) 0.96
Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. Stem Cells Dev (2014) 0.96
The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. Mol Biol Evol (2007) 0.95
Generation of activated sialoadhesin-positive microglia during retinal degeneration. Invest Ophthalmol Vis Sci (2003) 0.95
Visual pigments of the platypus: a novel route to mammalian colour vision. Curr Biol (2007) 0.95
Retinal dystrophies and gene therapy. Eur J Pediatr (2011) 0.94
Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther (2005) 0.94
Absence of chx10 causes neural progenitors to persist in the adult retina. Invest Ophthalmol Vis Sci (2006) 0.93
Hsp90 inhibition protects against inherited retinal degeneration. Hum Mol Genet (2013) 0.93
Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. Exp Eye Res (2004) 0.93
Cone visual pigments in two species of South American marsupials. Gene (2008) 0.93
Impact of engagement of FcepsilonRI and CC chemokine receptor 1 on mast cell activation and motility. J Biol Chem (2004) 0.92
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. Blood (2002) 0.91
Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system. Mol Ther (2007) 0.91
Predominant rod photoreceptor degeneration in Leber congenital amaurosis. Mol Vis (2005) 0.90
SPLICE: a technique for generating in vitro spliced coding sequences from genomic DNA. Biotechniques (2007) 0.90
Successful gene therapy in older Rpe65-deficient dogs following subretinal injection of an adeno-associated vector expressing RPE65. Hum Gene Ther (2013) 0.90
Divergent mechanisms for the tuning of shortwave sensitive visual pigments in vertebrates. Photochem Photobiol Sci (2004) 0.90
Into the blue: gene duplication and loss underlie color vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii. Genome Res (2009) 0.90
Gene therapy for ocular angiogenesis. Clin Sci (Lond) (2003) 0.89
Regenerative medicine: DIY eye. Nature (2011) 0.89
Induction of replication in human corneal endothelial cells by E2F2 transcription factor cDNA transfer. Invest Ophthalmol Vis Sci (2005) 0.89
Induced pluripotent stem cell technology for generating photoreceptors. Regen Med (2011) 0.89
Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. J Cell Biol (2013) 0.88