Monocytes: subsets, origins, fates and functions.

PubWeight™: 1.77‹?› | Rank: Top 3%

🔗 View Article (PMID 19770654)

Published in Curr Opin Hematol on January 01, 2010

Authors

Simon Yona1, Steffen Jung

Author Affiliations

1: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Articles citing this

Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol (2010) 4.07

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Exp Eye Res (2012) 2.18

Increased macrophage migration into adipose tissue in obese mice. Diabetes (2011) 1.98

A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment. Cytometry A (2011) 1.72

Macrophage phenotypes during tissue repair. J Leukoc Biol (2013) 1.67

Dexamethasone promotes tolerance in vivo by enriching CD11clo CD40lo tolerogenic macrophages. Eur J Immunol (2012) 1.45

Phenotypic transitions of macrophages orchestrate tissue repair. Am J Pathol (2013) 1.36

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J Exp Med (2013) 1.24

Functional diversity of microglia - how heterogeneous are they to begin with? Front Cell Neurosci (2013) 1.14

On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med (2013) 1.14

Innate immunity and monocyte-macrophage activation in atherosclerosis. J Inflamm (Lond) (2011) 1.07

Monocyte trafficking across the vessel wall. Cardiovasc Res (2015) 1.06

Impact of human granulocyte and monocyte isolation procedures on functional studies. Clin Vaccine Immunol (2012) 1.06

Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord. J Neurosci (2011) 1.03

Expansion of a subset of CD14highCD16negCCR2low/neg monocytes functionally similar to myeloid-derived suppressor cells during SIV and HIV infection. J Leukoc Biol (2012) 1.03

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery. J Bone Miner Res (2013) 1.02

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect (2011) 1.01

Punicalagin inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4-mediated MAPKs and NF-κB activation. Inflammation (2014) 1.01

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol (2014) 1.00

Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery. Nat Nanotechnol (2014) 0.98

Depletion of dendritic cells enhances innate anti-bacterial host defense through modulation of phagocyte homeostasis. PLoS Pathog (2012) 0.98

CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-α and IL-6 and promote cigarette smoke-induced emphysema. J Immunol (2011) 0.93

FluoroSpot Analysis of TLR-Activated Monocytes Reveals Several Distinct Cytokine-Secreting Subpopulations. Scand J Immunol (2012) 0.93

Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia. Blood (2015) 0.93

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. Clin Transl Med (2015) 0.90

Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plast (2013) 0.89

Monocytes and macrophages as nanomedicinal targets for improved diagnosis and treatment of disease. Expert Rev Mol Diagn (2013) 0.88

Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer. PLoS One (2012) 0.88

The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes. J Biol Chem (2011) 0.87

Innate immunity and resistance to tolerogenesis in allotransplantation. Front Immunol (2012) 0.85

Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7 macrophages. Chin Med (2015) 0.84

Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. J Exp Med (2015) 0.84

PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p. Mol Cell Biol (2015) 0.83

Dendritic cells in atherosclerosis. Semin Immunopathol (2013) 0.83

Characteristics of "Tip-DCs and MDSCs" and Their Potential Role in Leishmaniasis. Front Microbiol (2012) 0.83

Luminal microbes promote monocyte-stem cell interactions across a healthy colonic epithelium. J Immunol (2014) 0.82

Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation. Mediators Inflamm (2015) 0.82

Effects of dyslipidaemia on monocyte production and function in cardiovascular disease. Nat Rev Cardiol (2017) 0.81

A simplified, sensitive phagocytic assay for malaria cultures facilitated by flow cytometry of differentially-stained cell populations. PLoS One (2012) 0.81

Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PLoS One (2014) 0.81

Regulation of macrophage and dendritic cell responses by their lineage precursors. J Innate Immun (2012) 0.81

TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression. PLoS One (2015) 0.80

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes. Cell Rep (2015) 0.80

Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues. Immunol Invest (2015) 0.80

Heat-Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angew Chem Int Ed Engl (2015) 0.80

Cathelicidin impact on inflammatory cells. Cent Eur J Immunol (2015) 0.79

Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease. J Innate Immun (2012) 0.79

CD40 in coronary artery disease: a matter of macrophages? Basic Res Cardiol (2016) 0.78

Myeloid cells in cancer progression: unique subtypes and their roles in tumor growth, vascularity, and host immune suppression. Cancer Microenviron (2010) 0.78

Immunomodulatory effect of chinese herbal medicine formula sheng-fei-yu-chuan-tang in lipopolysaccharide-induced acute lung injury mice. Evid Based Complement Alternat Med (2013) 0.78

Reconstitution and functional analyses of neutrophils and distinct subsets of monocytes after allogeneic stem cell transplantation. J Cancer Res Clin Oncol (2011) 0.78

Macrophage polarization in kidney diseases. Macrophage (Houst) (2015) 0.78

All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development. Immunology (2013) 0.78

Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. J Immunol (2015) 0.77

Whole-Lung Irradiation Results in Pulmonary Macrophage Alterations that are Subpopulation and Strain Specific. Radiat Res (2015) 0.77

Zoledronic acid causes γδ T cells to target monocytes and down-modulate inflammatory homing. Immunology (2014) 0.76

Hormones and immunity in cancer: are thyroid hormones endocrine players in the microglia/glioma cross-talk? Front Cell Neurosci (2015) 0.76

Checkpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous System. Int J Mol Sci (2016) 0.75

Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare. BMC Syst Biol (2017) 0.75

Immunomodulatory effects of therapeutic plasma exchange on monocytes in antiphospholipid syndrome. Exp Ther Med (2016) 0.75

An intracameral injection of antigen induces in situ chemokines and cytokines required for the generation of circulating immunoregulatory monocytes. PLoS One (2012) 0.75

Dust-free bleaching powder may not prevent symptoms in hairdressers with bleaching-associated rhinitis. J Occup Health (2016) 0.75

[Immunosuppressives to prevent rejection reactions after allogeneic corneal transplantation]. Ophthalmologe (2014) 0.75

Phenotype, function, and differentiation potential of human monocyte subsets. PLoS One (2017) 0.75

Articles by these authors

(truncated to the top 100)

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods (2005) 5.59

Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med (2008) 5.42

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science (2014) 4.91

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med (2005) 4.34

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol (2005) 3.75

Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med (2009) 3.68

Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity (2012) 3.18

Distinct differentiation potential of blood monocyte subsets in the lung. J Immunol (2007) 3.16

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages. J Immunol (2007) 2.55

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood (2008) 2.52

Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol (2008) 2.33

Epigenetic ontogeny of the Igk locus during B cell development. Nat Immunol (2004) 2.25

Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med (2008) 2.15

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity (2013) 2.08

CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity (2006) 2.06

Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity (2008) 2.04

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci (2013) 2.03

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02

CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94

Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med (2008) 1.92

Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J (2004) 1.90

Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol (2006) 1.88

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood (2012) 1.82

Uterine DCs are crucial for decidua formation during embryo implantation in mice. J Clin Invest (2008) 1.82

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med (2011) 1.80

Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest (2006) 1.78

Three pathways to mature macrophages in the early mouse yolk sac. Blood (2005) 1.76

CKIα ablation highlights a critical role for p53 in invasiveness control. Nature (2011) 1.72

Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol (2007) 1.68

Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J Exp Med (2007) 1.68

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood (2011) 1.63

Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation. Eur J Immunol (2011) 1.56

Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route. J Immunol (2007) 1.56

Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest (2007) 1.51

Origins and tissue-context-dependent fates of blood monocytes. Immunol Cell Biol (2008) 1.50

Intestinal macrophages: well educated exceptions from the rule. Trends Immunol (2013) 1.47

CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol (2005) 1.44

Distinct in vivo dendritic cell activation by live versus killed Listeria monocytogenes. Eur J Immunol (2005) 1.40

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest (2011) 1.39

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Nat Immunol (2012) 1.38

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A (2007) 1.35

Defining dendritic cells by conditional and constitutive cell ablation. Immunol Rev (2010) 1.31

Macrophages: development and tissue specialization. Annu Rev Immunol (2015) 1.30

Microglia, seen from the CX3CR1 angle. Front Cell Neurosci (2013) 1.30

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells. Nat Cell Biol (2012) 1.27

The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium. Invest Ophthalmol Vis Sci (2007) 1.24

Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun (2006) 1.23

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense. Immunol Cell Biol (2013) 1.20

The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles. J Immunol (2005) 1.19

Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Immunity (2012) 1.17

Involvement of the CXCL12/CXCR4 pathway in the recovery of skin following burns. J Invest Dermatol (2006) 1.17

On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells. J Exp Med (2013) 1.14

Coupled pre-mRNA and mRNA dynamics unveil operational strategies underlying transcriptional responses to stimuli. Mol Syst Biol (2011) 1.13

Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol (2007) 1.13

CX3CR1+ c-kit+ bone marrow cells give rise to CD103+ and CD103- dendritic cells with distinct functional properties. J Immunol (2008) 1.07

TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia (2012) 1.06

Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells. Eur J Immunol (2006) 1.05

Microglia can be induced by IFN-gamma or IL-4 to express neural or dendritic-like markers. Mol Cell Neurosci (2007) 1.04

Probing in vivo dendritic cell functions by conditional cell ablation. Immunol Cell Biol (2008) 1.02

An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol (2006) 1.00

Utilization of murine colonoscopy for orthotopic implantation of colorectal cancer. PLoS One (2011) 1.00

Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood (2012) 0.99

Recruited macrophages control dissemination of group A Streptococcus from infected soft tissues. J Immunol (2011) 0.98

Defining in vivo dendritic cell functions using CD11c-DTR transgenic mice. Methods Mol Biol (2010) 0.98

Microglia: unique and common features with other tissue macrophages. Acta Neuropathol (2014) 0.97

The Shiga toxin B-subunit targets antigen in vivo to dendritic cells and elicits anti-tumor immunity. Eur J Immunol (2006) 0.97

A close encounter of the third kind: monocyte-derived cells. Adv Immunol (2013) 0.97

Toll-like receptor 4 is needed to restrict the invasion of Escherichia coli P4 into mammary gland epithelial cells in a murine model of acute mastitis. Cell Microbiol (2007) 0.97

The contribution of dendritic cells to host defenses against Streptococcus pyogenes. J Infect Dis (2007) 0.95

Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys. Antimicrob Agents Chemother (2008) 0.95

Systemic antitumor protection by vascular-targeted photodynamic therapy involves cellular and humoral immunity. Cancer Immunol Immunother (2008) 0.93

The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk. PLoS One (2011) 0.92

Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages? Semin Immunol (2011) 0.90

Clonal allelic predetermination of immunoglobulin-κ rearrangement. Nature (2012) 0.89

Dissecting the autocrine and paracrine roles of the CCR2-CCL2 axis in tumor survival and angiogenesis. PLoS One (2012) 0.89

CX₃CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium. Mol Cell Neurosci (2011) 0.87

CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium. J Neuroimmunol (2008) 0.86

Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow. Blood (2013) 0.84

Quantitative analysis of intravenously administered contrast media reveals changes in vascular barrier functions in a murine colitis model. Magn Reson Med (2011) 0.83

Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive. J Immunol (2008) 0.82

Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3. PLoS One (2013) 0.80

Probing in vivo origins of mononuclear phagocytes by conditional ablation and reconstitution. Methods Mol Biol (2009) 0.79

Bone marrow chimeric mice reveal a role for CX₃CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. J Leukoc Biol (2010) 0.78

Immunology. The axis of tolerance. Science (2014) 0.77

Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin. Antimicrob Agents Chemother (2009) 0.77

Unraveling chemokine and chemokine receptor expression patterns using genetically engineered mice. Methods Mol Biol (2013) 0.77