PubRank

Junichi Azuma

Author PubWeight™ 99.72‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 2004 3.92
2 A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004 2.75
3 Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol 2008 2.42
4 MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation. Diabetes Care 2003 1.56
5 Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol 2009 1.31
6 Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytes. Cardiovasc Res 2008 1.22
7 Glycoprotein 130 cytokine signal as a therapeutic target against cardiovascular diseases. J Pharmacol Sci 2011 1.21
8 Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 2010 1.14
9 ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007 1.14
10 Physiological roles of taurine in heart and muscle. J Biomed Sci 2010 1.13
11 Connective tissue growth factor induces cardiac hypertrophy through Akt signaling. Biochem Biophys Res Commun 2008 1.12
12 Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch Ophthalmol 2008 1.11
13 STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart. Cardiovasc Res 2005 1.11
14 Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy. J Mol Cell Cardiol 2008 1.08
15 Novel detection assay by PCR-RFLP and frequency of the CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese population. Pharmacogenetics 2002 1.07
16 Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells. Biochem J 2004 1.07
17 Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 2011 1.05
18 Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome. Am J Physiol Cell Physiol 2004 1.04
19 N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes. Biochem Biophys Res Commun 2005 1.03
20 Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage. Am J Physiol Heart Circ Physiol 2003 1.02
21 Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine. Cytokine 2007 1.02
22 Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol 2002 1.02
23 Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 2006 1.01
24 Why is taurine cytoprotective? Adv Exp Med Biol 2003 1.01
25 Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes. J Biol Chem 2006 0.99
26 Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochem Biophys Res Commun 2004 0.98
27 The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids 2011 0.98
28 N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. J Mol Cell Cardiol 2006 0.98
29 Influence of itraconazole co-administration and CYP2D6 genotype on the pharmacokinetics of the new antipsychotic ARIPIPRAZOLE. Drug Metab Pharmacokinet 2005 0.98
30 Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism. J Clin Oncol 2011 0.98
31 Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 2009 0.96
32 No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population. Br J Clin Pharmacol 2005 0.95
33 Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes. FEBS Lett 2004 0.95
34 Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress. Biochem Biophys Res Commun 2006 0.95
35 Effect of taurine and potential interactions with caffeine on cardiovascular function. Amino Acids 2014 0.94
36 STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo. J Mol Cell Cardiol 2011 0.92
37 Identification of the novel splicing variants for the hPXR in human livers. Biochem Biophys Res Commun 2002 0.91
38 Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients. Eur J Clin Pharmacol 2009 0.91
39 Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy. Int J Clin Oncol 2012 0.91
40 Pharmacokinetics of aripiprazole, a new antipsychotic, following oral dosing in healthy adult Japanese volunteers: influence of CYP2D6 polymorphism. Drug Metab Pharmacokinet 2007 0.90
41 Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. Int J Pharm 2007 0.89
42 Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. FEBS Lett 2005 0.89
43 Effect of taurine on ischemia-reperfusion injury. Amino Acids 2012 0.88
44 Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers. Cardiovasc Drugs Ther 2011 0.88
45 Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. J Biol Chem 2005 0.88
46 The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids 2013 0.87
47 Clinical significance of taurine. Amino Acids 2014 0.87
48 Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism. Int Clin Psychopharmacol 2005 0.87
49 MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. J Diabetes Complications 2008 0.87
50 Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects. Eur Neuropsychopharmacol 2009 0.87
51 Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2. Eur J Clin Pharmacol 2007 0.86
52 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res 2004 0.86
53 Polymorphisms of CYP2D6 gene and gefitinib-induced hepatotoxicity. Clin Lung Cancer 2013 0.86
54 Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. J Biomed Sci 2010 0.85
55 Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages. Biochim Biophys Acta 2003 0.85
56 Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells. Arterioscler Thromb Vasc Biol 2009 0.84
57 Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice. J Biomed Sci 2010 0.84
58 Marked hyperglycemia after androgen-deprivation therapy for prostate cancer and usefulness of pioglitazone for its treatment. Metabolism 2005 0.84
59 Possible cause of taurine-deficient cardiomyopathy: potentiation of angiotensin II action. J Cardiovasc Pharmacol 2003 0.84
60 Taurine renders the cell resistant to ischemia-induced injury in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol 2003 0.83
61 The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. J Clin Psychopharmacol 2008 0.83
62 Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers. Eur J Clin Pharmacol 2003 0.82
63 Novel structure of the CYP2D6 gene that confuses genotyping for the CYP2D6*5 allele. Drug Metab Pharmacokinet 2005 0.82
64 Myogenic differentiation induces taurine transporter in association with taurine-mediated cytoprotection in skeletal muscles. Biochem J 2006 0.82
65 Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways. Int J Pharm 2008 0.81
66 Molecular mechanisms of cardioprotection by taurine on ischemia-induced apoptosis in cultured cardiomyocytes. Adv Exp Med Biol 2006 0.81
67 Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study. Int J Cardiol 2012 0.81
68 Regulation of cytochrome P450 2E1 under hypertonic environment through TonEBP in human hepatocytes. Mol Pharmacol 2007 0.81
69 Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population. Hypertens Res 2011 0.80
70 Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice. Adv Exp Med Biol 2009 0.80
71 Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity. J Clin Pharmacol 2002 0.80
72 No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. Eur J Clin Pharmacol 2003 0.80
73 Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes. Drug Metab Dispos 2010 0.80
74 Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients. Prog Neuropsychopharmacol Biol Psychiatry 2008 0.80
75 Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line. Biochim Biophys Acta 2002 0.80
76 Involvement of transcriptional factor TonEBP in the regulation of the taurine transporter in the cardiomyocyte. Adv Exp Med Biol 2009 0.80
77 Future of pharmacogenetics-based therapy for tuberculosis. Pharmacogenomics 2014 0.79
78 Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients. Diabetes Res Clin Pract 2003 0.79
79 Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. Biochim Biophys Acta 2004 0.79
80 Isolation of putative glycoprotein gene from early somatic embryo of carrot and its possible involvement in somatic embryo development. Plant Cell Physiol 2004 0.79
81 Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression. Psychiatry Res 2012 0.79
82 Taurine transporter in cultured neonatal cardiomyocytes: a response to cardiac hypertrophy. Adv Exp Med Biol 2003 0.78
83 Role of taurine in the pathologies of MELAS and MERRF. Amino Acids 2012 0.78
84 Tool from traditional medicines is useful for health-medication: Bezoar Bovis and taurine. Adv Exp Med Biol 2009 0.78
85 Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals. Drug Metab Pharmacokinet 2009 0.78
86 5-HTTLPR rs25531A > G differentially influence paroxetine and fluvoxamine antidepressant efficacy: a randomized, controlled trial. J Clin Psychopharmacol 2013 0.78
87 Does taurine prolong lifespan by improving heart function? Adv Exp Med Biol 2015 0.77
88 Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis. Exp Clin Cardiol 2011 0.77
89 No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression. Neuropsychobiology 2008 0.77
90 Simple and accurate determination of CYP2D6 gene copy number by a loop-mediated isothermal amplification method and an electrochemical DNA chip. Clin Chim Acta 2010 0.77
91 [5-HT1A gene polymorphisms contributed to antidepressant response in major depression]. Nihon Shinkei Seishin Yakurigaku Zasshi 2009 0.77
92 MTHFR gene polymorphism and diabetic retinopathy. Curr Diabetes Rev 2006 0.77
93 Effect of taurine on protein kinase C isoforms: role in taurine's actions? Adv Exp Med Biol 2009 0.77
94 Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals. Drug Metab Pharmacokinet 2007 0.77
95 TauT gene expression is regulated by TonEBP and plays a role in cell survival. Adv Exp Med Biol 2006 0.77
96 Bioequivalence of rebamipide granules and tablets in healthy adult male volunteers. Clin Drug Investig 2003 0.76
97 Warfarin dose requirement for patients with both VKORC1 3673A/A and CYP2C9*3/*3 genotypes. Clin Pharmacol Ther 2006 0.76
98 Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients. Biol Pharm Bull 2008 0.76
99 Cellular characterization of taurine transporter in cultured cardiac myocytes and nonmyocytes. Adv Exp Med Biol 2003 0.76
100 Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males. Biol Pharm Bull 2007 0.76
101 Pharmacokinetics of pegylated recombinant human megakaryocyte growth and development factor in healthy volunteers and patients with hematological disorders. Eur J Haematol 2004 0.76
102 Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy. Adv Exp Med Biol 2006 0.76
103 [Taurine is a possible anti-atherosclerotic agent]. Nihon Yakurigaku Zasshi 2004 0.76
104 Taurine deficiency and MELAS are closely related syndromes. Adv Exp Med Biol 2013 0.76
105 [Genetic analysis for nicotine dependence]. Nihon Rinsho 2011 0.76
106 Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells. J Ethnopharmacol 2011 0.76
107 The frequency of candidate alleles for CYP2D6 genotyping in the Japanese population with an additional respect to the -1584C to G substitution. Drug Metab Pharmacokinet 2005 0.76
108 Taurine transporter in primary cultured neonatal rat heart cells: a comparison between cardiac myocytes and nonmyocytes. Biochem Pharmacol 2003 0.75
109 [Genetic polymorphism of CYP-450 in drug development]. Nihon Yakurigaku Zasshi 2009 0.75
110 Minoxidil attenuates ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes. J Cardiovasc Pharmacol 2004 0.75
111 Taurine Depletion Decreases GRP78 Expression and Downregulates Perk-Dependent Activation of the Unfolded Protein Response. Adv Exp Med Biol 2015 0.75
112 [Genetic polymorphism in heart failure]. Nihon Rinsho 2007 0.75
113 Potential Anti-aging Role of Taurine via Proper Protein Folding: A Study from Taurine Transporter Knockout Mouse. Adv Exp Med Biol 2015 0.75
114 [A case of bleeding tendency due to warfarin in a patient treated with chemotherapy by S-1]. Gan To Kagaku Ryoho 2008 0.75
115 Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy. Osaka City Med J 2015 0.75
116 [Progress in research on function and mechanism of cardiac vascular system of taurine]. Zhongguo Zhong Yao Za Zhi 2005 0.75
117 Modulation of taurine on CYP3A4 induction by rifampicin in a HepG2 cell line. Adv Exp Med Biol 2003 0.75
118 [Pharmacogenomics]. Nihon Yakurigaku Zasshi 2005 0.75
119 Determination of single nucleotide polymorphisms in N-acetyltransferase2 gene using an electrochemical DNA chip and an automated DNA detection system. Rinsho Byori 2007 0.75
120 [Current status of tailor-made medicine and the role of clinical pharmacology]. Nihon Yakurigaku Zasshi 2003 0.75
121 The quest for an animal model of diabetic nephropathy and the role of taurine deficiency. Adv Exp Med Biol 2015 0.75
122 Long-term effects of candesartan and amlodipine on cardiovascular mortality and morbidity in Japanese high-risk hypertensive patients: rationale, design, and characteristics of candesartan antihypertensive survival evaluation in Japan extension (CASE-J Ex). Contemp Clin Trials 2008 0.75
123 Urinary excretion of ipecac alkaloids in human volunteers. Vet Hum Toxicol 2002 0.75
124 Repeated-dose pharmacokinetics of inhaled ciclesonide (CIC-HFA) in Japanese children with bronchial asthma: a phase I study. Allergol Int 2012 0.75
125 Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers. Drug Metab Pharmacokinet 2008 0.75