Published in Trends Biotechnol on December 13, 2012
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
Efficient programmable gene silencing by Cascade. Nucleic Acids Res (2014) 1.00
Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. ACS Synth Biol (2013) 0.94
Biomedically relevant circuit-design strategies in mammalian synthetic biology. Mol Syst Biol (2013) 0.93
Building synthetic memory. Curr Biol (2013) 0.92
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
A designer cell-based histamine-specific human allergy profiler. Nat Commun (2014) 0.89
General method for regulating protein stability with light. ACS Chem Biol (2013) 0.88
Mammalian synthetic biology: emerging medical applications. J R Soc Interface (2015) 0.86
Metabolic flux rewiring in mammalian cell cultures. Curr Opin Biotechnol (2013) 0.85
Synthetic mammalian trigger-controlled bipartite transcription factors. Nucleic Acids Res (2013) 0.84
Synthetic biology in cell-based cancer immunotherapy. Trends Biotechnol (2015) 0.84
Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res (2015) 0.81
High-yield, zero-leakage expression system with a translational switch using site-specific unnatural amino Acid incorporation. Appl Environ Microbiol (2013) 0.81
Design and characterization of a dual-mode promoter with activation and repression capability for tuning gene expression in yeast. Nucleic Acids Res (2014) 0.80
Systematic transfer of prokaryotic sensors and circuits to mammalian cells. ACS Synth Biol (2014) 0.79
Antagonistic control of a dual-input mammalian gene switch by food additives. Nucleic Acids Res (2014) 0.79
Cosmetics-triggered percutaneous remote control of transgene expression in mice. Nucleic Acids Res (2015) 0.77
Engineering cell-cell signaling. Curr Opin Biotechnol (2013) 0.76
Molecular Buffers Permit Sensitivity Tuning and Inversion of Riboswitch Signals. ACS Synth Biol (2016) 0.75
A dual molecular analogue tuner for dissecting protein function in mammalian cells. Nat Commun (2016) 0.75
Multi-compartment encapsulation of communicating droplets and droplet networks in hydrogel as a model for artificial cells. Sci Rep (2017) 0.75
Recent advances and versatility of MAGE towards industrial applications. Syst Synth Biol (2015) 0.75
A tunable synthetic mammalian oscillator. Nature (2009) 4.33
Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng (2003) 3.04
An engineered epigenetic transgene switch in mammalian cells. Nat Biotechnol (2004) 3.02
A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science (2011) 2.77
Programmable single-cell mammalian biocomputers. Nature (2012) 2.56
Adult stem cell therapy of female stress urinary incontinence. Eur Urol (2007) 2.48
Retracted Autologous myoblasts and fibroblasts versus collagen for treatment of stress urinary incontinence in women: a randomised controlled trial. Lancet (2007) 2.35
Drug-sensing hydrogels for the inducible release of biopharmaceuticals. Nat Mater (2008) 2.23
Hysteresis in a synthetic mammalian gene network. Proc Natl Acad Sci U S A (2005) 2.12
Emerging biomedical applications of synthetic biology. Nat Rev Genet (2011) 2.05
BioLogic gates enable logical transcription control in mammalian cells. Biotechnol Bioeng (2004) 1.97
Synthetic two-way communication between mammalian cells. Nat Biotechnol (2012) 1.78
Synthetic ecosystems based on airborne inter- and intrakingdom communication. Proc Natl Acad Sci U S A (2007) 1.77
Macrolide-based transgene control in mammalian cells and mice. Nat Biotechnol (2002) 1.72
A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. Nat Commun (2013) 1.71
A synthetic mammalian gene circuit reveals antituberculosis compounds. Proc Natl Acad Sci U S A (2008) 1.68
Self-sufficient control of urate homeostasis in mice by a synthetic circuit. Nat Biotechnol (2010) 1.64
A synthetic time-delay circuit in mammalian cells and mice. Proc Natl Acad Sci U S A (2007) 1.59
Microscale tissue engineering using gravity-enforced cell assembly. Trends Biotechnol (2004) 1.55
Autologous myoblasts and fibroblasts for female stress incontinence: a 1-year follow-up in 123 patients. BJU Int (2007) 1.55
SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase. Gene (2002) 1.45
A synthetic erectile optogenetic stimulator enabling blue-light-inducible penile erection. Angew Chem Int Ed Engl (2015) 1.44
The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J (2010) 1.40
Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction. Nucleic Acids Res (2002) 1.37
Design of custom-shaped vascularized tissues using microtissue spheroids as minimal building units. Tissue Eng (2006) 1.29
Gas-inducible transgene expression in mammalian cells and mice. Nat Biotechnol (2004) 1.27
Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection. J Biotechnol (2009) 1.26
An engineered mammalian band-pass network. Nucleic Acids Res (2010) 1.16
Mammalian synthetic biology: engineering of sophisticated gene networks. J Biotechnol (2007) 1.15
Design of artificial myocardial microtissues. Tissue Eng (2004) 1.12
Engineering of synthetic mammalian gene networks. Chem Biol (2009) 1.12
Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice. Nucleic Acids Res (2003) 1.07
Macrolide- and tetracycline-adjustable siRNA-mediated gene silencing in mammalian cells using polymerase II-dependent promoter derivatives. Biotechnol Bioeng (2004) 1.05
Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol Bioeng (2003) 1.04
Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin. Proc Natl Acad Sci U S A (2009) 1.03
Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells. Metab Eng (2006) 1.02
Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering. J Biotechnol (2002) 1.01
VEGF profiling and angiogenesis in human microtissues. J Biotechnol (2005) 1.00
A genetic time-delay circuitry in mammalian cells. Biotechnol Bioeng (2007) 1.00
Scaffold-free cell delivery for use in regenerative medicine. Adv Drug Deliv Rev (2010) 1.00
Molecular diversity--the toolbox for synthetic gene switches and networks. Curr Opin Chem Biol (2011) 0.99
Pharmacologic transgene control systems for gene therapy. J Gene Med (2006) 0.99
The food additive vanillic acid controls transgene expression in mammalian cells and mice. Nucleic Acids Res (2011) 0.99
Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. J Biol Chem (2005) 0.98
A synthetic low-frequency mammalian oscillator. Nucleic Acids Res (2010) 0.97
A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms. J Control Release (2010) 0.97
A genetic redox sensor for mammalian cells. Metab Eng (2006) 0.97
An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases. Biotechnol Adv (2013) 0.96
The use of light for engineered control and reprogramming of cellular functions. Curr Opin Biotechnol (2011) 0.96
Vitamin H-regulated transgene expression in mammalian cells. Nucleic Acids Res (2007) 0.96
Myoblast and fibroblast therapy for post-prostatectomy urinary incontinence: 1-year followup of 63 patients. J Urol (2007) 0.96
Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch. Nucleic Acids Res (2008) 0.95
Synthetic mammalian gene circuits for biomedical applications. Curr Opin Chem Biol (2013) 0.95
Tissue-transplant fusion and vascularization of myocardial microtissues and macrotissues implanted into chicken embryos and rats. Tissue Eng (2006) 0.95
Novel CNBP- and La-based translation control systems for mammalian cells. Biotechnol Bioeng (2003) 0.94
Modeling the quorum sensing regulatory network of human-pathogenic Pseudomonas aeruginosa. Biotechnol Prog (2004) 0.94
Biomedically relevant circuit-design strategies in mammalian synthetic biology. Mol Syst Biol (2013) 0.93
Toward construction of a self-sustained clock-like expression system based on the mammalian circadian clock. Biotechnol Bioeng (2004) 0.93
A synthetic mammalian electro-genetic transcription circuit. Nucleic Acids Res (2009) 0.93
Recent advances in mammalian synthetic biology-design of synthetic transgene control networks. Curr Opin Biotechnol (2009) 0.93
Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. Proc Natl Acad Sci U S A (2012) 0.93
Multi-gene engineering: simultaneous expression and knockdown of six genes off a single platform. Biotechnol Bioeng (2007) 0.93
Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles. Nucleic Acids Res (2006) 0.92
Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system. Nucleic Acids Res (2003) 0.92
Inducible product gene expression technology tailored to bioprocess engineering. Curr Opin Biotechnol (2007) 0.92
Engineering of synthetic intercellular communication systems. Metab Eng (2012) 0.91
Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering. Biotechnol Bioeng (2002) 0.91
An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice. Nucleic Acids Res (2007) 0.90
Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media. Biotechnol Bioeng (2002) 0.90
Dual-regulated expression of C/EBP-alpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts. Nucleic Acids Res (2004) 0.90
Impact of RNA interference on gene networks. Metab Eng (2006) 0.90
A designer cell-based histamine-specific human allergy profiler. Nat Commun (2014) 0.89
Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells. Biotechnol Bioeng (2010) 0.89
Engineering molecular circuits using synthetic biology in mammalian cells. Annu Rev Chem Biomol Eng (2012) 0.89
Synthetic biology: Synchronized bacterial clocks. Nature (2010) 0.89
Broad-spectrum protein biosensors for class-specific detection of antibiotics. Biotechnol Bioeng (2005) 0.89
Smart medication through combination of synthetic biology and cell microencapsulation. Metab Eng (2011) 0.89
Novel promoter/transactivator configurations for macrolide- and streptogramin-responsive transgene expression in mammalian cells. J Gene Med (2002) 0.89
Semi-synthetic mammalian gene regulatory networks. Metab Eng (2005) 0.89
Transgene control engineering in mammalian cells. Methods Mol Biol (2005) 0.89
Ligand-dependent regulatory RNA parts for Synthetic Biology in eukaryotes. Curr Opin Biotechnol (2010) 0.89
Differential effect of exocytic SNAREs on the production of recombinant proteins in mammalian cells. Biotechnol Bioeng (2010) 0.88
A biotin-triggered genetic switch in mammalian cells and mice. Metab Eng (2009) 0.88
A novel reporter system for bacterial and mammalian cells based on the non-ribosomal peptide indigoidine. Metab Eng (2012) 0.87
The impact of synthetic biology on drug discovery. Drug Discov Today (2009) 0.87
Engineering of ribozyme-based riboswitches for mammalian cells. Methods (2012) 0.87
Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression. Tissue Eng Part A (2008) 0.87
Mammalian synthetic biology--from tools to therapies. Bioessays (2010) 0.86
Rational design of a small molecule-responsive intramer controlling transgene expression in mammalian cells. Nucleic Acids Res (2011) 0.86
Life after the synthetic cell. Nature (2010) 0.86
A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1. Nucleic Acids Res (2005) 0.86
Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles. Metab Eng (2005) 0.86
Design and in vivo characterization of self-inactivating human and non-human lentiviral expression vectors engineered for streptogramin-adjustable transgene expression. Nucleic Acids Res (2004) 0.86
De novo design and construction of an inducible gene expression system in mammalian cells. Methods Enzymol (2011) 0.86
Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels. Macromol Rapid Commun (2012) 0.85
A novel system for trigger-controlled drug release from polymer capsules. J Control Release (2008) 0.85
Self-assembly of sensory neurons into ganglia-like microtissues. J Biotechnol (2005) 0.85
The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells. Metab Eng (2009) 0.85
Genetically programmed superparamagnetic behavior of mammalian cells. J Biotechnol (2012) 0.84
New-generation multicistronic expression platform: pTRIDENT vectors containing size-optimized IRES elements enable homing endonuclease-based cistron swapping into lentiviral expression vectors. Biotechnol Bioeng (2004) 0.84