Published in ACS Synth Biol on November 22, 2013
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Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector. Nucleic Acids Res (2014) 1.59
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FLASH assembly of TALENs for high-throughput genome editing. Nat Biotechnol (2012) 12.97
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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
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CRISPR RNA-guided activation of endogenous human genes. Nat Methods (2013) 4.69
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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
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Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods (2013) 3.26
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Robust, synergistic regulation of human gene expression using TALE activators. Nat Methods (2013) 2.89
Programmable single-cell mammalian biocomputers. Nature (2012) 2.56
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell (1992) 2.37
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Distributed biological computation with multicellular engineered networks. Nature (2010) 2.13
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods (2012) 2.07
TALEN-based gene correction for epidermolysis bullosa. Mol Ther (2013) 1.84
Synthetic two-way communication between mammalian cells. Nat Biotechnol (2012) 1.78
Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. J Am Chem Soc (2012) 1.69
Foundations for the design and implementation of synthetic genetic circuits. Nat Rev Genet (2012) 1.65
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. Mol Ther (2013) 1.63
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Directed evolution of the TALE N-terminal domain for recognition of all 5' bases. Nucleic Acids Res (2013) 1.08
Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins. Proc Natl Acad Sci U S A (2004) 1.04
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
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Benzoate X receptor zinc-finger gene switches for drug-inducible regulation of transcription. Gene Ther (2011) 0.83
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Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions. Acc Chem Res (2004) 1.92
Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA. J Mol Biol (2006) 1.91
Modular system for the construction of zinc-finger libraries and proteins. Nat Protoc (2010) 1.87
Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation. Angew Chem Int Ed Engl (2013) 1.85
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst. Proc Natl Acad Sci U S A (2003) 1.78
Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry (2002) 1.60
Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res (2012) 1.38
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector. Int J Cancer (2006) 1.37
Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 1.34
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase. J Am Chem Soc (2007) 1.33
Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proc Natl Acad Sci U S A (2010) 1.31
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Exploring strategies for the design of artificial transcription factors: targeting sites proximal to known regulatory regions for the induction of gamma-globin expression and the treatment of sickle cell disease. J Biol Chem (2004) 1.30
Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display. J Mol Biol (2003) 1.30
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices. J Med Chem (2004) 1.29
Evolution of programmable zinc finger-recombinases with activity in human cells. J Mol Biol (2007) 1.28
Breaking the one antibody-one target axiom. Proc Natl Acad Sci U S A (2006) 1.26
Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl (2005) 1.25
Instant immunity through chemically programmable vaccination and covalent self-assembly. Proc Natl Acad Sci U S A (2009) 1.25
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem (2004) 1.24
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg Med Chem Lett (2006) 1.22
Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol (2004) 1.20
Directed evolution of recombinase specificity by split gene reassembly. Nucleic Acids Res (2010) 1.19
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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res (2011) 1.13
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A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. J Mol Biol (2003) 1.11
Integrin alpha(v)beta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody. FASEB J (2002) 1.11
An efficient chemical approach to bispecific antibodies and antibodies of high valency. Bioorg Med Chem Lett (2009) 1.11
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs. Nat Protoc (2007) 1.10
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A modular assembly strategy for improving the substrate specificity of small catalytic peptides. J Am Chem Soc (2002) 1.09
Tyrosine bioconjugation through aqueous ene-type reactions: a click-like reaction for tyrosine. J Am Chem Soc (2010) 1.08
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Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol (2006) 1.07
Genetic reprogramming of tumor cells by zinc finger transcription factors. Proc Natl Acad Sci U S A (2005) 1.07
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{gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice. J Biol Chem (2005) 1.06
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Res (2013) 1.04
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Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation. Proc Natl Acad Sci U S A (2007) 1.04
Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2. Bioorg Med Chem Lett (2009) 1.03
ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging. Tumour Biol (2012) 1.03
A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids. J Am Chem Soc (2002) 1.03
A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives. J Am Chem Soc (2002) 1.03
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles. J Org Chem (2003) 1.02
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Synthesis of beta-hydroxyaldehydes with stereogenic quaternary carbon centers by direct organocatalytic asymmetric aldol reactions. Angew Chem Int Ed Engl (2004) 1.00
Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library. J Immunol Methods (2004) 1.00
Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations. J Am Chem Soc (2004) 0.99
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation. J Mol Biol (2004) 0.98
Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid. J Am Chem Soc (2006) 0.98
ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies). Protein Eng Des Sel (2010) 0.97
Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection. Bioconjug Chem (2009) 0.97
Controlling gene expression in plants using synthetic zinc finger transcription factors. Plant J (2002) 0.97
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Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine. J Am Chem Soc (2009) 0.97
Proline-catalyzed one-step asymmetric synthesis of 5-hydroxy-(2E)-hexenal from acetaldehyde. J Org Chem (2002) 0.96
Highly enantio- and diastereoselective Mannich reactions of glycine Schiff bases with in situ generated N-Boc-imines catalyzed by a cinchona alkaloid thiourea. Org Lett (2010) 0.96
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Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Res (2005) 0.95
Organocatalytic direct asymmetric aldol reactions in water. J Am Chem Soc (2006) 0.95
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Small-molecule switches for zinc finger transcription factors. J Am Chem Soc (2003) 0.94
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