Published in Mol Biochem Parasitol on December 16, 2012
Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies. Nat Rev Microbiol (2013) 0.98
Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. Mol Biol Cell (2013) 0.92
Neospora caninum Recruits Host Cell Structures to Its Parasitophorous Vacuole and Salvages Lipids from Organelles. Eukaryot Cell (2015) 0.78
Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase. PLoS Pathog (2016) 0.75
Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites. J Biol Chem (2017) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
A rapid bootstrap algorithm for the RAxML Web servers. Syst Biol (2008) 38.22
Multiple sequence alignment with Clustal X. Trends Biochem Sci (1998) 15.10
Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun (1996) 3.67
Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods (2005) 3.42
Identification of a family of animal sphingomyelin synthases. EMBO J (2003) 3.03
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun (1995) 2.42
New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A. Antimicrob Agents Chemother (1984) 2.32
Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem (1997) 2.21
Association of host cell endoplasmic reticulum and mitochondria with the Toxoplasma gondii parasitophorous vacuole membrane: a high affinity interaction. J Cell Sci (1997) 2.16
Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J Cell Biol (2000) 1.96
The lipid transfer protein CERT interacts with the Chlamydia inclusion protein IncD and participates to ER-Chlamydia inclusion membrane contact sites. PLoS Pathog (2011) 1.74
Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog (2011) 1.60
Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J Cell Sci (2002) 1.54
CERT-mediated trafficking of ceramide. Biochim Biophys Acta (2009) 1.46
Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast. EMBO J (2006) 1.42
Plasmodium falciparum exports the Golgi marker sphingomyelin synthase into a tubovesicular network in the cytoplasm of mature erythrocytes. J Cell Biol (1994) 1.39
The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. J Biol Chem (2006) 1.39
Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis. Cell Microbiol (2000) 1.32
Role of sphingolipids in microbial pathogenesis. Infect Immun (2006) 1.27
Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids. J Biol Chem (1992) 1.25
A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. J Biol Chem (1997) 1.25
Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more. J Cell Biol (2002) 1.22
The accumulation and metabolism of a fluorescent ceramide derivative in Plasmodium falciparum-infected erythrocytes. Mol Biochem Parasitol (1991) 1.12
A temperature-sensitive mammalian cell mutant with thermolabile serine palmitoyltransferase for the sphingolipid biosynthesis. J Biol Chem (1990) 1.06
Sphingolipids in infectious diseases. Jpn J Infect Dis (2005) 1.05
Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem (2008) 1.03
Biosynthesis of glycosphingolipids de-novo by the human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol (2001) 1.00
Protein and lipid trafficking induced in erythrocytes infected by malaria parasites. Cell Microbiol (2002) 1.00
Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids. Biochemistry (2007) 1.00
Characterization of the inositol phosphorylceramide synthase activity from Trypanosoma cruzi. Biochem J (2005) 0.96
Sphingolipid metabolism and signaling minireview series. J Biol Chem (2002) 0.96
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Mol Biochem Parasitol (2009) 0.91
Plasmodium falciparum-infected erythrocytes utilize a synthetic truncated ceramide precursor for synthesis and secretion of truncated sphingomyelin. Biochem J (1995) 0.91
Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii. Int J Parasitol (2002) 0.88
Inhibitory effect of aureobasidin A on Toxoplasma gondii. Antimicrob Agents Chemother (2005) 0.88
Evidence for host cells as the major contributor of lipids in the intravacuolar network of Toxoplasma-infected cells. Eukaryot Cell (2011) 0.87
Antifungals targeted to sphingolipid synthesis: focus on inositol phosphorylceramide synthase. Expert Opin Investig Drugs (2000) 0.86
Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase. Plant Mol Biol (2010) 0.84
New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma. Cell Microbiol (2007) 0.83
A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase. Int J Biochem Cell Biol (2010) 0.82
Toxoplasmosis: a review. J Med (1986) 0.80
Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes. Biochem Res Int (2011) 0.79
Sphingolipid and ceramide homeostasis: potential therapeutic targets. Biochem Res Int (2012) 0.77
Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. EMBO J (2002) 1.99
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol (2007) 1.95
Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. J Biol Chem (2006) 1.79
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. PLoS Biol (2012) 1.79
Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J Virol (2008) 1.65
Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog (2011) 1.60
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy (2009) 1.60
Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major. J Biol Chem (2003) 1.52
Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements. Mol Biol Cell (2006) 1.49
Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti. Nucleic Acids Res (2012) 1.49
Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy (2007) 1.45
CERT mediates intermembrane transfer of various molecular species of ceramides. J Biol Chem (2004) 1.44
Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Proc Natl Acad Sci U S A (2008) 1.39
The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. J Biol Chem (2006) 1.39
Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT. J Biol Chem (2007) 1.39
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res (2007) 1.38
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett (2009) 1.35
Evidence that clustered phosphocholine head groups serve as sites for binding and assembly of an oligomeric protein pore. J Biol Chem (2006) 1.31
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res (2010) 1.28
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infection. Fungal Genet Biol (2005) 1.25
De novo ceramide accumulation due to inhibition of its conversion to complex sphingolipids in apoptotic photosensitized cells. J Biol Chem (2004) 1.21
Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells. J Biol Chem (2002) 1.21
Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. Exp Cell Res (2008) 1.19
A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans. Mol Biol Cell (2007) 1.16
Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis. J Clin Invest (2002) 1.14
Inhibitors of sphingolipid metabolism enzymes. Biochim Biophys Acta (2006) 1.14
The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences. Trends Parasitol (2002) 1.12
Roles of glycosylphosphatidylinositols of Toxoplasma gondii. Induction of tumor necrosis factor-alpha production in macrophages. J Biol Chem (2003) 1.11
Identification of the archaeal alg7 gene homolog (encoding N-acetylglucosamine-1-phosphate transferase) of the N-linked glycosylation system by cross-domain complementation in Saccharomyces cerevisiae. J Bacteriol (2008) 1.09
A role for the de novo sphingolipids in apoptosis of photosensitized cells. Exp Cell Res (2002) 1.08
A role for manganese superoxide dismutase in apoptosis after photosensitization. Biochem Biophys Res Commun (2005) 1.07
Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism. IUBMB Life (2008) 1.07
Neogenesis and maturation of transient Golgi-like cisternae in a simple eukaryote. J Cell Sci (2009) 1.06
A potent adjuvant monophosphoryl lipid A triggers various immune responses, but not secretion of IL-1beta or activation of caspase-1. J Immunol (2006) 1.05
The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system. Trends Parasitol (2002) 1.05
Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage. Biochem Biophys Res Commun (2007) 1.05
Differential effects of modification of membrane cholesterol and sphingolipids on the conformation, function, and trafficking of the G protein-coupled cholecystokinin receptor. J Biol Chem (2004) 1.04
Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase. ChemMedChem (2008) 1.03
Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase. J Org Chem (2003) 1.01
Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog Lipid Res (2011) 1.01
Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication. Int J Parasitol (2002) 1.01
Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. J Biol Chem (2005) 1.01
A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis. Mol Cell Biol (2012) 1.00
Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem (2004) 1.00
Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer. J Mol Biol (2009) 1.00
Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells. J Biol Chem (2007) 0.99
Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. J Biol Chem (2007) 0.99
Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J Biol Chem (2010) 0.99
Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. Bioorg Med Chem (2008) 0.98
Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1. J Lipid Res (2007) 0.97
An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei. Mol Cell Biol (2005) 0.97
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids (2006) 0.96
Protein-sphingolipid interactions within cellular membranes. J Lipid Res (2007) 0.96
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem (2007) 0.96
Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells. Diabetes (2013) 0.96
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol (2012) 0.95
Recognition of plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitol Res (2002) 0.95
Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna. Environ Health Perspect (2015) 0.94
Reactive oxygen species generation is independent of de novo sphingolipids in apoptotic photosensitized cells. Exp Cell Res (2003) 0.94
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem (2014) 0.94
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
Synthesis and phospholipase C inhibitory activity of D609 diastereomers. Lipids (2002) 0.93
Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles. Cell Struct Funct (2008) 0.93
The immunogenic properties of protozoan glycosylphosphatidylinositols in the mosquito Anopheles gambiae. Dev Comp Immunol (2008) 0.93
Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease. ChemMedChem (2007) 0.92
Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis. Biochimie (2003) 0.92
C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth. Breast Cancer Res Treat (2011) 0.92
Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell (2008) 0.92
Synthesis of chloroplast galactolipids in apicomplexan parasites. Eukaryot Cell (2002) 0.92
Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. Mol Biol Cell (2013) 0.92
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Mol Biochem Parasitol (2009) 0.91
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem (2011) 0.91
Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum. Infect Immun (2002) 0.91
Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria. Arterioscler Thromb Vasc Biol (2011) 0.91
Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chem Biol (2010) 0.91
Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins. Traffic (2014) 0.90
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide. Prostate (2010) 0.90
Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage. Arch Biochem Biophys (2009) 0.90
Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry. Environ Sci Pollut Res Int (2014) 0.89
Exit of GPI-anchored proteins from the ER differs in yeast and mammalian cells. Traffic (2010) 0.89
Immunological reactions in response to apicomplexan glycosylphosphatidylinositols. Glycobiology (2010) 0.89
Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii. Int J Parasitol (2002) 0.88
Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease. Blood Cells Mol Dis (2009) 0.87
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J (2012) 0.87
Enhancement of de novo fatty acid biosynthesis in hepatic cell line Huh7 expressing hepatitis C virus core protein. Biol Pharm Bull (2006) 0.87
Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids. Biochem J (2004) 0.87
Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities. Org Biomol Chem (2005) 0.87
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res (2010) 0.87
Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta (2013) 0.86
Plasmodium falciparum: glycosylation status of Plasmodium falciparum circumsporozoite protein expressed in the baculovirus system. Exp Parasitol (2002) 0.86