Published in ChemMedChem on June 01, 2008
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev (2008) 2.96
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem (2011) 1.15
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem (2012) 1.05
Dihydroceramide-based response to hypoxia. J Biol Chem (2011) 1.02
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem (2014) 0.94
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res (2010) 0.87
Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta (2013) 0.86
Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells. J Biol Chem (2014) 0.84
Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells. J Lipid Res (2012) 0.83
Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II. J Lipid Res (2014) 0.83
A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget (2015) 0.81
Predicting and characterizing selective multiple drug treatments for metabolic diseases and cancer. BMC Syst Biol (2012) 0.81
Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol (2013) 0.80
Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii. Mol Biochem Parasitol (2012) 0.80
Host cell P-glycoprotein is essential for cholesterol uptake and replication of Toxoplasma gondii. J Biol Chem (2009) 0.79
Introduction of caveolae structural proteins into the protozoan Toxoplasma results in the formation of heterologous caveolae but not caveolar endocytosis. PLoS One (2012) 0.79
Dihydroceramide desaturase inhibition by a cyclopropanated dihydroceramide analog in cultured keratinocytes. J Lipids (2010) 0.75
Antifungal activity of Myriocin on clinically relevant Aspergillus fumigatus strains producing biofilm. BMC Microbiol (2015) 0.75
Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1. PLoS Biol (2012) 1.79
[Double-wire technique for implanting a left ventricular venous lead in patients with complicated coronary venous anatomy]. Rev Esp Cardiol (2007) 1.55
[Six-month intravascular ultrasound follow-up of coronary bifurcation lesions treated with rapamycin-eluting stents: technical considerations]. Rev Esp Cardiol (2005) 1.39
Ultrasound findings during percutaneous treatment of bifurcated coronary lesions. Rev Esp Cardiol (2008) 1.38
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells. Cancer Lett (2009) 1.35
Is shade beneficial for mediterranean shrubs experiencing periods of extreme drought and late-winter frosts? Ann Bot (2008) 1.29
Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Prog Lipid Res (2010) 1.28
Flow-structure-acoustic interaction in a human voice model. J Acoust Soc Am (2009) 1.27
Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy. Am Heart J (2004) 1.25
An unexpected chelation-controlled Yb(OTf)(3)-catalyzed aminolysis and azidolysis of cyclitol epoxides. J Org Chem (2002) 1.17
Inhibitors of sphingolipid metabolism enzymes. Biochim Biophys Acta (2006) 1.14
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 1.11
Evidence for in situ crude oil biodegradation after the Prestige oil spill. Environ Microbiol (2005) 1.06
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem (2012) 1.05
Rapamycin-eluting stents for the treatment of unprotected left main coronary disease. Am Heart J (2004) 1.02
Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase. J Org Chem (2003) 1.01
Drug-eluting stents for the treatment of bifurcation lesions: a randomized comparison between paclitaxel and sirolimus stents. Am Heart J (2007) 1.01
Dihydroceramide desaturase and dihydrosphingolipids: debutant players in the sphingolipid arena. Prog Lipid Res (2011) 1.01
Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and analysis of enantiomers by capillary electrophoresis. J Anal Toxicol (2002) 1.01
NKT TCR recognition of CD1d-α-C-galactosylceramide. J Immunol (2011) 0.99
Bioremediation of 2,4,6-trinitrotoluene by bacterial nitroreductase expressing transgenic aspen. Environ Sci Technol (2008) 0.99
Analysis of the flow field induced by the sessile peritrichous ciliate Opercularia asymmetrica. J Biomech (2006) 0.99
Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells. Stem Cells Dev (2009) 0.98
Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines. Bioorg Med Chem (2008) 0.98
Goats, birds, and emergent diseases: apparent and hidden effects of exotic species in an island environment. Ecol Appl (2009) 0.97
Cellular changes that accompany shedding of human corneocytes. J Invest Dermatol (2012) 0.97
Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Chem Phys Lipids (2006) 0.96
Synthesis of a novel ceramide analogue and its use in a high-throughput fluorogenic assay for ceramidases. Chembiochem (2007) 0.96
Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy. Int J Biochem Cell Biol (2012) 0.95
Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna. Environ Health Perspect (2015) 0.94
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem (2014) 0.94
Systemic ceramide accumulation leads to severe and varied pathological consequences. EMBO Mol Med (2013) 0.94
A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease. J Lipid Res (2010) 0.94
A multifunctional desaturase involved in the biosynthesis of the processionary moth sex pheromone. Proc Natl Acad Sci U S A (2007) 0.93
Synthesis and phospholipase C inhibitory activity of D609 diastereomers. Lipids (2002) 0.93
Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons. Mol Pharmacol (2004) 0.92
C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth. Breast Cancer Res Treat (2011) 0.92
Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease. ChemMedChem (2007) 0.92
Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine. J Biol Chem (2011) 0.91
Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chem Biol (2010) 0.91
Effectiveness of percutaneous device occlusion for atrial septal defect in adult patients with pulmonary hypertension. Am Heart J (2002) 0.90
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide. Prostate (2010) 0.90
The cumulative effect of three decades of phosphogypsum amendments in reclaimed marsh soils from SW Spain: (226)Ra, (238)U and Cd contents in soils and tomato fruit. Sci Total Environ (2008) 0.89
Phosphogypsum amendment effect on radionuclide content in drainage water and marsh soils from southwestern Spain. J Environ Qual (2003) 0.89
Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry. Environ Sci Pollut Res Int (2014) 0.89
Can synchronizing feather-based measures of corticosterone and stable isotopes help us better understand habitat-physiology relationships? Oecologia (2013) 0.88
Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer. Mol Cancer Ther (2012) 0.88
Spatial heterogeneity in resource distribution promotes facultative sociality in two trans-Saharan migratory birds. PLoS One (2011) 0.88
Expression and evolution of delta9 and delta11 desaturase genes in the moth Spodoptera littoralis. Insect Biochem Mol Biol (2004) 0.87
Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia. J Lipid Res (2010) 0.87
Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities. Org Biomol Chem (2005) 0.87
The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J (2012) 0.87
C75 activates malonyl-CoA sensitive and insensitive components of the CPT system. Biochem Biophys Res Commun (2004) 0.87
Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease. Blood Cells Mol Dis (2009) 0.87
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochim Biophys Acta (2013) 0.86
Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol (2012) 0.86
Specific sphingolipid content decrease in Cerkl knockdown mouse retinas. Exp Eye Res (2013) 0.86
Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells. J Lipid Res (2005) 0.86
Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem (2009) 0.86
Opinions of French patients with schizophrenia regarding injectable medication. Patient Prefer Adherence (2011) 0.86
Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites by gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom (2003) 0.85
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase. Org Biomol Chem (2011) 0.85
Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells. J Am Chem Soc (2011) 0.85
Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides. Chem Phys Lipids (2008) 0.85