Published in Biochem J on March 15, 2013
RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64
Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3. Nat Struct Mol Biol (2013) 1.20
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med (2013) 1.14
Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase. Cell Death Differ (2014) 0.79
Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J Biol Chem (2015) 0.78
Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. Nat Struct Mol Biol (2015) 0.78
HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization. Oncotarget (2014) 0.77
The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K. Sci Rep (2015) 0.77
Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structure. J Biol Chem (2014) 0.76
Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. PLoS One (2016) 0.76
The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation. J Biol Chem (2014) 0.76
Glioblastomas with copy number gains in EGFR and RNF139 show increased expressions of carbonic anhydrase genes transformed by ENO1. BBA Clin (2015) 0.75
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J Biol Chem (2001) 2.33
B-type natriuretic peptide signal peptide circulates in human blood: evaluation as a potential biomarker of cardiac ischemia. Circulation (2010) 2.26
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol (2008) 2.11
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices. Mol Cell (2009) 2.04
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol (2008) 1.94
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A (2005) 1.91
Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J Biol Chem (2008) 1.87
CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. Mol Cell (2011) 1.78
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem (2009) 1.68
Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1). J Mol Biol (2002) 1.61
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60
Severe oxidative stress causes inactivation of DnaK and activation of the redox-regulated chaperone Hsp33. Mol Cell (2005) 1.60
The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. EMBO J (2003) 1.59
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1. Structure (2014) 1.58
The Bcl-2-regulated apoptotic pathway. J Cell Sci (2003) 1.53
RINGs hold the key to ubiquitin transfer. Trends Biochem Sci (2011) 1.50
Identification of a redox-regulated chaperone network. EMBO J (2003) 1.46
The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly. J Mol Biol (2013) 1.46
Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models. Mol Cancer Ther (2014) 1.42
Structural plasticity underpins promiscuous binding of the prosurvival protein A1. Structure (2008) 1.42
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. J Cell Biol (2002) 1.41
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
The Bcl-2 family: structures, interactions and targets for drug discovery. Apoptosis (2015) 1.29
Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies. J Med Chem (2014) 1.27
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem (2011) 1.25
RING domain dimerization is essential for RNF4 function. Biochem J (2010) 1.20
Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology (2007) 1.14
Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol (2005) 1.10
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. J Biol Chem (2010) 1.09
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J (2004) 1.07
Asymmetric recruitment of cIAPs by TRAF2. J Mol Biol (2010) 1.04
Mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. J Biol Chem (2007) 1.01
Intrinsically disordered proteins in bcl-2 regulated apoptosis. Int J Mol Sci (2010) 1.00
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys J (2007) 0.98
Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains. Biochemistry (2009) 0.97
Proteome analysis of the rice etioplast: metabolic and regulatory networks and novel protein functions. Mol Cell Proteomics (2005) 0.96
Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol Microbiol (2014) 0.95
Solution structure of Psb27 from cyanobacterial photosystem II. Biochemistry (2009) 0.94
Analysis of shotgun proteomics and RNA profiling data from Arabidopsis thaliana chloroplasts. J Proteome Res (2005) 0.94
Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain. FEBS J (2011) 0.93
Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4. Bioorg Med Chem Lett (2006) 0.91
Reevaluation of abscisic acid-binding assays shows that G-Protein-Coupled Receptor2 does not bind abscisic Acid. Plant Physiol (2009) 0.90
FCA does not bind abscisic acid. Nature (2008) 0.90
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J Biol Chem (2002) 0.90
Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radic Biol Med (2013) 0.89
Can dolphins heal by ultrasound? J Theor Biol (2003) 0.88
The G82S polymorphism promotes glycosylation of the receptor for advanced glycation end products (RAGE) at asparagine 81: comparison of wild-type rage with the G82S polymorphic variant. J Biol Chem (2011) 0.87
The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. J Biol Chem (2001) 0.87
Genomic and proteomic analysis of invertebrate iridovirus type 9. J Virol (2011) 0.86
A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome. PLoS One (2010) 0.86
Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase. Biochemistry (2013) 0.86
Unprecedented binding cooperativity between Cu(I) and Cu(II) in the copper resistance protein CopK from Cupriavidus metallidurans CH34: implications from structural studies by NMR spectroscopy and X-ray crystallography. J Am Chem Soc (2009) 0.83
Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding. J Proteomics (2011) 0.83
First identification of circulating prepro-A-type natriuretic peptide (preproANP) signal peptide fragments in humans: initial assessment as cardiovascular biomarkers. Clin Chem (2012) 0.83
The structure of Boo/Diva reveals a divergent Bcl-2 protein. Proteins (2010) 0.83
Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D 1H-15N heteronuclear correlation spectra acquired with band-selective pulses. J Magn Reson (2011) 0.82
Proteomic analysis of aortae from human lipoprotein(a) transgenic mice shows an early metabolic response independent of atherosclerosis. PLoS One (2012) 0.81
The discovery and structure-activity relationships of pyrano[3,4-b]indole based inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett (2010) 0.80
Solution structure of CyanoP from Synechocystis sp. PCC 6803: new insights on the structural basis for functional specialization amongst PsbP family proteins. Biochim Biophys Acta (2012) 0.80
The application of MALDI TOF MS in biopharmaceutical research. Int J Pharm (2010) 0.80
FRIGIDA and related proteins have a conserved central domain and family specific N- and C- terminal regions that are functionally important. Plant Mol Biol (2010) 0.79
Structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally twinned crystal form. Acta Crystallogr D Biol Crystallogr (2002) 0.78
The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett (2011) 0.77
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics. Cancer Cell (2016) 0.77
The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity. ChemMedChem (2008) 0.76
Molecular basis of the cooperative binding of Cu(I) and Cu(II) to the CopK protein from Cupriavidus metallidurans CH34. Biochemistry (2011) 0.76
Characterization of Peptide Polymer Interactions in Poly(alkylcyanoacrylate) Nanoparticles: A Mass Spectrometric Approach. Curr Drug Deliv (2010) 0.75
Self-assembled nanomaterials based on beta (β (3)) tetrapeptides. Nanotechnology (2016) 0.75
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. J Biol Chem (2017) 0.75
Characterization of Peptide Polymer Interactions in Poly(alkylcyanoacrylate) Nanoparticles: A Mass Spectrometric Approach. Curr Drug Deliv (2010) 0.75
Histidine residues in the peptide D-Lys(6)-GnRH: potential for copolymerization in polymeric nanoparticles. Mol Pharm (2009) 0.75
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function. Metallomics (2014) 0.75
HtrA--a renaissance protein. Structure (2002) 0.75