Published in J Mol Biol on June 04, 2008
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat Chem Biol (2010) 3.17
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell (2010) 2.89
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Many players in BCL-2 family affairs. Trends Biochem Sci (2014) 1.64
Delving deeper: MCL-1's contributions to normal and cancer biology. Trends Cell Biol (2012) 1.60
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ (2013) 1.54
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem (2012) 1.53
Protein binding specificity versus promiscuity. Curr Opin Struct Biol (2010) 1.52
A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2013) 1.42
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. Blood (2010) 1.41
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat Chem Biol (2013) 1.28
Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. Cancer Res (2012) 1.25
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci (2010) 1.24
Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chem Biol (2013) 1.15
Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'. J Am Chem Soc (2013) 1.11
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Predictive Bcl-2 family binding models rooted in experiment or structure. J Mol Biol (2012) 1.09
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A (2011) 1.09
Evolution of Bcl-2 homology motifs: homology versus homoplasy. Trends Cell Biol (2012) 1.08
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein. Proc Natl Acad Sci U S A (2014) 1.06
Distinct cellular and therapeutic effects of obatoclax in rituximab-sensitive and -resistant lymphomas. Br J Haematol (2011) 1.04
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. Mol Cancer (2013) 1.04
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. J Biol Chem (2009) 1.03
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem (2011) 1.02
Apoptotic regulation by MCL-1 through heterodimerization. J Biol Chem (2010) 1.02
Structural biology of the Bcl-2 family and its mimicry by viral proteins. Cell Death Dis (2013) 1.01
Intrinsically disordered proteins in bcl-2 regulated apoptosis. Int J Mol Sci (2010) 1.00
Coupled folding and binding of the disordered protein PUMA does not require particular residual structure. J Am Chem Soc (2014) 1.00
Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization. Sci Rep (2012) 0.96
Structure-guided rational design of α/β-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem (2013) 0.96
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2. Biochemistry (2012) 0.96
Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function. PLoS One (2012) 0.95
BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods (2013) 0.94
Mapping the interaction of pro-apoptotic tBID with pro-survival BCL-XL. Biochemistry (2009) 0.94
Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Curr Top Med Chem (2011) 0.93
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis (2012) 0.88
KLF4 overexpression and apigenin treatment down regulated anti-apoptotic Bcl-2 proteins and matrix metalloproteinases to control growth of human malignant neuroblastoma SK-N-DZ and IMR-32 cells. Mol Oncol (2012) 0.86
Identification of a novel Mcl-1 protein binding motif. J Biol Chem (2011) 0.86
High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug design. PLoS One (2014) 0.86
Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteins. PLoS Comput Biol (2014) 0.85
Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell (2011) 0.85
Survival control of malignant lymphocytes by anti-apoptotic MCL-1. Leukemia (2016) 0.85
The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains. J Biol Chem (2014) 0.84
Heterodimerization of BAK and MCL-1 activated by detergent micelles. J Biol Chem (2010) 0.83
Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family. J Biol Chem (2015) 0.83
Comprehensive repertoire of foldable regions within whole genomes. PLoS Comput Biol (2013) 0.82
Proapoptotic role of nuclear clusterin in brain. Anat Cell Biol (2011) 0.82
Targeting Cell Survival Proteins for Cancer Cell Death. Pharmaceuticals (Basel) (2016) 0.81
A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions. Assay Drug Dev Technol (2011) 0.80
Bcl-2 phosphorylation confers resistance on chronic lymphocytic leukaemia cells to the BH3 mimetics ABT-737, ABT-263 and ABT-199 by impeding direct binding. Br J Pharmacol (2016) 0.80
High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations. Mol Biosyst (2015) 0.80
An Integrated Bioinformatics and Computational Biology Approach Identifies New BH3-Only Protein Candidates. Open Biol J (2012) 0.79
CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins. Biophys J (2017) 0.79
Intrinsically disordered energy landscapes. Sci Rep (2015) 0.78
The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane. FEBS J (2016) 0.78
Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. Cancer Res (2017) 0.77
Structural biology of the intrinsic cell death pathway: what do we know and what is missing? Comput Struct Biotechnol J (2012) 0.75
The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS One (2015) 0.75
Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH. Biophys J (2016) 0.75
Protein-protein interactions: A PUMA mechanism unfolds. Nat Chem Biol (2013) 0.75
Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1. PLoS Comput Biol (2017) 0.75
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells. Cancer Biol Ther (2014) 0.75
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure. Proc Natl Acad Sci U S A (2017) 0.75
Structure-based approach to the design of BakBH3 mimetic peptides with increased helical propensity. J Mol Model (2013) 0.75
Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget (2017) 0.75
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell (2013) 2.75
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature (2009) 2.54
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes Dev (2012) 2.44
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol (2009) 2.27
Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med (2007) 2.20
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood (2012) 1.81
CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration. Mol Cell (2011) 1.78
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A (2008) 1.73
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem (2009) 1.68
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition. J Biol Chem (2003) 1.64
Structure of domain III of the blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1). J Mol Biol (2002) 1.61
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1. Structure (2014) 1.58
(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. J Am Chem Soc (2007) 1.56
The Bcl-2-regulated apoptotic pathway. J Cell Sci (2003) 1.53
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc (2011) 1.49
Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1. Infect Immun (2005) 1.48
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. Mol Cell (2007) 1.47
Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study. Lancet (2002) 1.46
Structural plasticity underpins promiscuous binding of the prosurvival protein A1. Structure (2008) 1.42
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem (2003) 1.38
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev (2014) 1.30
The Bcl-2 family: structures, interactions and targets for drug discovery. Apoptosis (2015) 1.29
Structural basis for DNA recognition and loading into a viral packaging motor. Proc Natl Acad Sci U S A (2011) 1.19
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A (2011) 1.09
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J (2004) 1.07
Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proc Natl Acad Sci U S A (2009) 1.07
Asymmetric recruitment of cIAPs by TRAF2. J Mol Biol (2010) 1.04
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem (2011) 1.04
Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy. Proc Natl Acad Sci U S A (2007) 1.03
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. J Biol Chem (2009) 1.03
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem (2011) 1.02
Intrinsically disordered proteins in bcl-2 regulated apoptosis. Int J Mol Sci (2010) 1.00
Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide. Biophys J (2007) 0.98
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA. J Biol Chem (2003) 0.97
Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains. Biochemistry (2009) 0.97
Structure-guided rational design of α/β-peptide foldamers with high affinity for BCL-2 family prosurvival proteins. Chembiochem (2013) 0.96
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. J Med Chem (2011) 0.95
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine. J Mol Biol (2009) 0.95
Solution structure of Psb27 from cyanobacterial photosystem II. Biochemistry (2009) 0.94
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling. J Biol Chem (2003) 0.93
Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. J Biol Chem (2002) 0.90
Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase. Biochem J (2013) 0.89
The nuclease domain of the SPP1 packaging motor coordinates DNA cleavage and encapsidation. Nucleic Acids Res (2012) 0.88
The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. J Biol Chem (2001) 0.87
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem (2013) 0.86
Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins. Structure (2011) 0.86
Unprecedented binding cooperativity between Cu(I) and Cu(II) in the copper resistance protein CopK from Cupriavidus metallidurans CH34: implications from structural studies by NMR spectroscopy and X-ray crystallography. J Am Chem Soc (2009) 0.83
Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains. Structure (2011) 0.83
The structure of Boo/Diva reveals a divergent Bcl-2 protein. Proteins (2010) 0.83
Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D 1H-15N heteronuclear correlation spectra acquired with band-selective pulses. J Magn Reson (2011) 0.82
Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues. Biopolymers (2011) 0.80
Recombinant portal protein from Staphylococcus epidermidis bacteriophage CNPH82 is a 13-subunit oligomer. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.80
Solution structure of CyanoP from Synechocystis sp. PCC 6803: new insights on the structural basis for functional specialization amongst PsbP family proteins. Biochim Biophys Acta (2012) 0.80
How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism. PLoS One (2011) 0.79
Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes. Mol Hum Reprod (2003) 0.78
Trp RNA-binding attenuation protein: modifying symmetry and stability of a circular oligomer. PLoS One (2012) 0.77
Molecular basis of the cooperative binding of Cu(I) and Cu(II) to the CopK protein from Cupriavidus metallidurans CH34. Biochemistry (2011) 0.76
The putative small terminase from the thermophilic dsDNA bacteriophage G20C is a nine-subunit oligomer. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.75
Expression, purification, crystallization and preliminary X-ray studies of the TAN1 orthologue from Methanothermobacter thermautotrophicus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
HtrA--a renaissance protein. Structure (2002) 0.75
Self-assembled nanomaterials based on beta (β (3)) tetrapeptides. Nanotechnology (2016) 0.75
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function. Metallomics (2014) 0.75