Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus).

PubWeight™: 2.45‹?› | Rank: Top 2%

🔗 View Article (PMID 23263233)

Published in Nat Biotechnol on December 23, 2012

Authors

Yang Dong1, Min Xie, Yu Jiang, Nianqing Xiao, Xiaoyong Du, Wenguang Zhang, Gwenola Tosser-Klopp, Jinhuan Wang, Shuang Yang, Jie Liang, Wenbin Chen, Jing Chen, Peng Zeng, Yong Hou, Chao Bian, Shengkai Pan, Yuxiang Li, Xin Liu, Wenliang Wang, Bertrand Servin, Brian Sayre, Bin Zhu, Deacon Sweeney, Rich Moore, Wenhui Nie, Yongyi Shen, Ruoping Zhao, Guojie Zhang, Jinquan Li, Thomas Faraut, James Womack, Yaping Zhang, James Kijas, Noelle Cockett, Xun Xu, Shuhong Zhao, Jun Wang, Wen Wang

Author Affiliations

1: State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Articles citing this

Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions. Nat Biotechnol (2013) 2.05

The genome of Prunus mume. Nat Commun (2012) 1.80

Design and characterization of a 52K SNP chip for goats. PLoS One (2014) 1.79

A comprehensive evaluation of assembly scaffolding tools. Genome Biol (2014) 1.55

Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology. Gigascience (2014) 1.36

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nat Biotechnol (2013) 1.36

Genetic variation and the de novo assembly of human genomes. Nat Rev Genet (2015) 1.24

High-quality genome (re)assembly using chromosomal contact data. Nat Commun (2014) 1.08

Fluorescence in situ hybridization and optical mapping to correct scaffold arrangement in the tomato genome. G3 (Bethesda) (2014) 0.99

SNPchiMp v.3: integrating and standardizing single nucleotide polymorphism data for livestock species. BMC Genomics (2015) 0.97

Genetic anchoring of whole-genome shotgun assemblies. Front Genet (2014) 0.96

A divergent Artiodactyl MYADM-like repeat is associated with erythrocyte traits and weight of lamb weaned in domestic sheep. PLoS One (2013) 0.94

Genome-wide association studies for growth and meat production traits in sheep. PLoS One (2013) 0.92

Reference genes selection for quantitative real-time PCR using RankAggreg method in different tissues of Capra hircus. PLoS One (2013) 0.88

Characterization of Liaoning cashmere goat transcriptome: sequencing, de novo assembly, functional annotation and comparative analysis. PLoS One (2013) 0.88

Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat (Capra hircus). PLoS One (2013) 0.87

BioNano genome mapping of individual chromosomes supports physical mapping and sequence assembly in complex plant genomes. Plant Biotechnol J (2016) 0.86

Single-Molecule Real-Time Sequencing Combined with Optical Mapping Yields Completely Finished Fungal Genome. MBio (2015) 0.86

Identification of selection signatures in livestock species. Genet Mol Biol (2014) 0.85

Analysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype. Sci Rep (2014) 0.85

Introgression from domestic goat generated variation at the major histocompatibility complex of Alpine ibex. PLoS Genet (2014) 0.85

Using optical mapping data for the improvement of vertebrate genome assemblies. Gigascience (2015) 0.85

Two Mutations in the Caprine MTHFR 3'UTR Regulated by MicroRNAs Are Associated with Milk Production Traits. PLoS One (2015) 0.85

Single-molecule sequencing and chromatin conformation capture enable de novo reference assembly of the domestic goat genome. Nat Genet (2017) 0.84

Super-resolution mbPAINT for optical localization of single-stranded DNA. ACS Appl Mater Interfaces (2013) 0.84

Genes regulating lipid and protein metabolism are highly expressed in mammary gland of lactating dairy goats. Funct Integr Genomics (2014) 0.83

Reference genome of wild goat (capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication. BMC Genomics (2015) 0.83

Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats. PLoS One (2016) 0.83

Genome sequencing and analysis of Mangalica, a fatty local pig of Hungary. BMC Genomics (2014) 0.82

Generation of five human lactoferrin transgenic cloned goats using fibroblast cells and their methylation status of putative differential methylation regions of IGF2R and H19 imprinted genes. PLoS One (2013) 0.81

Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data. Front Genet (2015) 0.81

Genome-wide analysis of long non-coding RNAs at early stage of skin pigmentation in goats (Capra hircus). BMC Genomics (2016) 0.81

OPTIMA: sensitive and accurate whole-genome alignment of error-prone genomic maps by combinatorial indexing and technology-agnostic statistical analysis. Gigascience (2016) 0.81

Toward single-molecule optical mapping of the epigenome. ACS Nano (2013) 0.81

Multiple genomic signatures of selection in goats and sheep indigenous to a hot arid environment. Heredity (Edinb) (2015) 0.81

De Novo Transcriptome Assembly of the Chinese Swamp Buffalo by RNA Sequencing and SSR Marker Discovery. PLoS One (2016) 0.81

Misassembly detection using paired-end sequence reads and optical mapping data. Bioinformatics (2015) 0.80

Frequent loss and alteration of the MOXD2 gene in catarrhines and whales: a possible connection with the evolution of olfaction. PLoS One (2014) 0.80

Food Deprivation Affects the miRNome in the Lactating Goat Mammary Gland. PLoS One (2015) 0.79

Epigenetic marks: regulators of livestock phenotypes and conceivable sources of missing variation in livestock improvement programs. Front Genet (2015) 0.79

Exome sequencing reveals genetic differentiation due to high-altitude adaptation in the Tibetan cashmere goat (Capra hircus). BMC Genomics (2016) 0.79

Identification of differentially expressed miRNAs between white and black hair follicles by RNA-sequencing in the goat (Capra hircus). Int J Mol Sci (2014) 0.78

Single-molecule optical genome mapping of a human HapMap and a colorectal cancer cell line. Gigascience (2015) 0.78

RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk. BMC Vet Res (2016) 0.77

Evolutionary history of bovine endogenous retroviruses in the Bovidae family. BMC Evol Biol (2013) 0.77

Genome-wide analysis of miRNAs in the ovaries of Jining Grey and Laiwu Black goats to explore the regulation of fecundity. Sci Rep (2016) 0.77

Rapid construction of genome map for large yellow croaker (Larimichthys crocea) by the whole-genome mapping in BioNano Genomics Irys system. BMC Genomics (2015) 0.77

Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10. Anim Genet (2015) 0.77

Genome-wide identification and characterization of long non-coding RNAs in developmental skeletal muscle of fetal goat. BMC Genomics (2016) 0.77

Scaling of the spring in the leg during bouncing gaits of mammals. Integr Comp Biol (2014) 0.77

Scaffolding of long read assemblies using long range contact information. BMC Genomics (2017) 0.76

Goat genome sequence by optical mapping. Nat Biotechnol (2013) 0.76

Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics (2015) 0.76

Genome-Wide Search for Host Association Factors during Ovine Progressive Pneumonia Virus Infection. PLoS One (2016) 0.76

Improvement of the banana "Musa acuminata" reference sequence using NGS data and semi-automated bioinformatics methods. BMC Genomics (2016) 0.76

Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells. PLoS One (2014) 0.76

An update of the goat genome assembly using dense radiation hybrid maps allows detailed analysis of evolutionary rearrangements in Bovidae. BMC Genomics (2014) 0.76

Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus). Sci Rep (2016) 0.75

Whole-genome optical mapping and finished genome sequence of Sphingobacterium deserti sp. nov., a new species isolated from the Western Desert of China. PLoS One (2015) 0.75

LaGomiCs-Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order. J Hered (2016) 0.75

Comparative Transcriptome Analysis Reveals that a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats. PLoS One (2016) 0.75

Identification and comparative analysis of the ovarian microRNAs of prolific and non-prolific goats during the follicular phase using high-throughput sequencing. Sci Rep (2017) 0.75

Genomic organization and evolution of ruminant lysozyme c genes. Dongwuxue Yanjiu (2015) 0.75

OMBlast: alignment tool for optical mapping using a seed-and-extend approach. Bioinformatics (2017) 0.75

Association of polymorphisms at the microRNA binding site of the caprine KITLG 3'-UTR with litter size. Sci Rep (2016) 0.75

De novo assembly of Dekkera bruxellensis: a multi technology approach using short and long-read sequencing and optical mapping. Gigascience (2015) 0.75

Capturing goats: documenting two hundred years of mitochondrial DNA diversity among goat populations from Britain and Ireland. Biol Lett (2017) 0.75

Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity. DNA Res (2016) 0.75

MaGuS: a tool for quality assessment and scaffolding of genome assemblies with Whole Genome Profiling™ Data. BMC Bioinformatics (2016) 0.75

Web-based bioinformatics workflows for end-to-end RNA-seq data computation and analysis in agricultural animal species. BMC Genomics (2016) 0.75

Identification and Expression Profiling of miRNAome in Goat longissimus dorsi Muscle from Prenatal Stages to a Neonatal Stage. PLoS One (2016) 0.75

Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene (2016) 0.75

A Screen for Key Genes and Pathways Involved in High-Quality Brush Hair in the Yangtze River Delta White Goat. PLoS One (2017) 0.75

Analysis of single nucleic acid molecules in micro- and nano-fluidics. Lab Chip (2016) 0.75

Multiple alternative splicing and differential expression pattern of the glycogen synthase kinase-3β (GSK3β) gene in goat (Capra hircus). PLoS One (2014) 0.75

Characterization of genome-wide segmental duplications reveals a common genomic feature of association with immunity among domestic animals. BMC Genomics (2017) 0.75

Genome Wide Association Study Identifies New Loci Associated with Undesired Coat Color Phenotypes in Saanen Goats. PLoS One (2016) 0.75

Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation. Sci Rep (2016) 0.75

Endogenous retroviruses in domestic animals. Curr Genomics (2014) 0.75

A golden goat genome. Nat Genet (2017) 0.75

A genome-wide perspective about the diversity and demographic history of seven Spanish goat breeds. Genet Sel Evol (2016) 0.75

Quality Assessment of Domesticated Animal Genome Assemblies. Bioinform Biol Insights (2016) 0.75

An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes. Nat Commun (2016) 0.75

Rapid Fermentable Substance Modulates Interactions between Ruminal Commensals and Toll-Like Receptors in Promotion of Immune Tolerance of Goat Rumen. Front Microbiol (2016) 0.75

Detecting Positive Selection of Korean Native Goat Populations Using Next-Generation Sequencing. Mol Cells (2016) 0.75

Whole-genome sequencing of eight goat populations for the detection of selection signatures underlying production and adaptive traits. Sci Rep (2016) 0.75

Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system. Sci Rep (2016) 0.75

The Valdostana goat: a genome-wide investigation of the distinctiveness of its selective sweep regions. Mamm Genome (2017) 0.75

New cryptic karyotypic differences between cattle (Bos taurus) and goat (Capra hircus). Chromosome Res (2015) 0.75

Identification of differentially expressed genes through RNA sequencing in goats (Capra hircus) at different postnatal stages. PLoS One (2017) 0.75

Whole-Genome Restriction Mapping by "Subhaploid"-Based RAD Sequencing: An Efficient and Flexible Approach for Physical Mapping and Genome Scaffolding. Genetics (2017) 0.75

Articles cited by this

tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res (1997) 142.55

BLAT--the BLAST-like alignment tool. Genome Res (2002) 126.78

MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics (2001) 101.31

TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13

The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res (2000) 67.44

The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05

Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res (1999) 49.21

De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91

PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci (1997) 45.07

KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res (1999) 40.62

The Pfam protein families database. Nucleic Acids Res (2011) 33.46

Rfam: annotating non-coding RNAs in complete genomes. Nucleic Acids Res (2005) 25.49

The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res (2009) 19.70

Infernal 1.0: inference of RNA alignments. Bioinformatics (2009) 12.98

CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes. Bioinformatics (2007) 12.21

A unified classification system for eukaryotic transposable elements. Nat Rev Genet (2007) 11.03

PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res (1991) 9.18

Limitations of next-generation genome sequence assembly. Nat Methods (2010) 9.04

TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83

The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23

When less is more: gene loss as an engine of evolutionary change. Am J Hum Genet (1999) 5.32

Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu Rev Biochem (1987) 4.98

The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94

Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41

KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15

The initial domestication of goats (Capra hircus) in the Zagros mountains 10,000 years ago. Science (2000) 4.09

Assessing the gene space in draft genomes. Nucleic Acids Res (2008) 4.03

LTR_FINDER: an efficient tool for the prediction of full-length LTR retrotransposons. Nucleic Acids Res (2007) 3.89

MaskerAid: a performance enhancement to RepeatMasker. Bioinformatics (2000) 3.66

A universal classification of eukaryotic transposable elements implemented in Repbase. Nat Rev Genet (2008) 3.17

InterPro and InterProScan: tools for protein sequence classification and comparison. Methods Mol Biol (2007) 3.05

CAFE: a computational tool for the study of gene family evolution. Bioinformatics (2006) 3.02

Multiple maternal origins and weak phylogeographic structure in domestic goats. Proc Natl Acad Sci U S A (2001) 2.87

Scaffolding and validation of bacterial genome assemblies using optical restriction maps. Bioinformatics (2008) 2.61

Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates. PLoS Biol (2004) 2.56

Validation of rice genome sequence by optical mapping. BMC Genomics (2007) 2.44

Shotgun optical maps of the whole Escherichia coli O157:H7 genome. Genome Res (2001) 2.43

A single molecule scaffold for the maize genome. PLoS Genet (2009) 2.33

Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci U S A (1999) 2.25

Livestock genetic origins: goats buck the trend. Proc Natl Acad Sci U S A (2001) 1.92

The PRINTS database: a fine-grained protein sequence annotation and analysis resource--its status in 2012. Database (Oxford) (2012) 1.80

Keratin classes: molecular markers for different types of epithelial differentiation. J Invest Dermatol (1983) 1.76

Retinoic acid stimulates regeneration of mammalian auditory hair cells. Science (1993) 1.74

The physical and genetic framework of the maize B73 genome. PLoS Genet (2009) 1.64

International System for Chromosome Nomenclature of Domestic Bovids (ISCNDB 2000). Cytogenet Cell Genet (2001) 1.54

Subtractive hybridization and optical mapping of the enterotoxigenic Escherichia coli H10407 chromosome: isolation of unique sequences and demonstration of significant similarity to the chromosome of E. coli K-12. Microbiology (2006) 1.44

Optical mapping of the Mycobacterium avium subspecies paratuberculosis genome. BMC Genomics (2009) 1.37

Human hair keratin-associated proteins (KAPs). Int Rev Cytol (2006) 1.30

Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Biotechnology (N Y) (1991) 1.27

The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. J Pediatr Endocrinol Metab (2000) 1.23

Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome. Proc Natl Acad Sci U S A (2009) 1.04

Growth of secondary hair follicles of the Cashmere goat in vitro and their response to prolactin and melatonin. J Anat (1994) 0.97

FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5. Development (2005) 0.96

Desmogleins 1 and 3 in the companion layer anchor mouse anagen hair to the follicle. J Invest Dermatol (2004) 0.93

Chromosome studies in the superfamily Bovoidea. Chromosoma (1968) 0.93

Production of biologically active human granulocyte colony stimulating factor in the milk of transgenic goat. Transgenic Res (2000) 0.92

Chromosome evolution in domestic bovids as revealed by chromosome banding and FISH-mapping techniques. Cytogenet Genome Res (2009) 0.92

Human KAP genes, only the half of it? Extensive size polymorphisms in hair keratin-associated protein genes. J Invest Dermatol (2005) 0.89

A complete DNA sequence map of the ovine major histocompatibility complex. BMC Genomics (2010) 0.88

Cow placenta extract promotes murine hair growth through enhancing the insulin - like growth factor-1. Indian J Dermatol (2011) 0.87

A distributed computation of Interpro Pfam, PROSITE and ProDom for protein annotation. Genet Mol Res (2005) 0.80

Retinoic acid and mouse skin morphogenesis. II. Role of epidermal competence in hair glandular metaplasia. Dev Biol (1994) 0.80

Articles by these authors

SOAP: short oligonucleotide alignment program. Bioinformatics (2008) 68.13

The diploid genome sequence of an Asian individual. Nature (2008) 46.29

De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91

A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics (2009) 39.47

Enterotypes of the human gut microbiome. Nature (2011) 24.36

SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48

Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01

SNP detection for massively parallel whole-genome resequencing. Genome Res (2009) 15.96

The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76

WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06

Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55

A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25

Major causes of death among men and women in China. N Engl J Med (2005) 11.80

A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature (2012) 11.68

Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27

CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Res (2006) 9.19

TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res (2006) 8.83

The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23

The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell (2003) 8.11

An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94

Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77

The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67

Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) 7.64

Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature (2010) 7.51

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res (2008) 7.45

FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22

Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med (2011) 7.11

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93

TreeFam: 2008 Update. Nucleic Acids Res (2007) 6.63

A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron (2007) 6.60

A transcription factor response element for gene expression during circadian night. Nature (2002) 6.55

The comprehensive antibiotic resistance database. Antimicrob Agents Chemother (2013) 6.41

The origin of new genes: glimpses from the young and old. Nat Rev Genet (2003) 6.14

Whole-genome cartography of estrogen receptor alpha binding sites. PLoS Genet (2007) 5.85

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73

Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62

Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57

Building the sequence map of the human pan-genome. Nat Biotechnol (2009) 5.53

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell (2006) 5.51

Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants. Nat Genet (2010) 5.44

The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30

A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24

Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20

Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm. Cell (2012) 5.16

Enzyme-specific profiles for genome annotation: PRIAM. Nucleic Acids Res (2003) 5.10

System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet (2005) 5.10

Impact of creatinine calibration on performance of GFR estimating equations in a pooled individual patient database. Am J Kidney Dis (2007) 5.06

Prevalence of the metabolic syndrome and overweight among adults in China. Lancet (2005) 5.05

CASTp: Computed Atlas of Surface Topography of proteins. Nucleic Acids Res (2003) 4.93

Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nat Biotechnol (2011) 4.84

An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science (2011) 4.76

Mortality attributable to smoking in China. N Engl J Med (2009) 4.75

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int (2011) 4.74

Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ (2011) 4.50