Published in Diabetes on December 28, 2012
Nutritional Prevention Pilot Trial for Type 1 Diabetes (MIP) | NCT00570102
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host Microbe (2015) 2.58
Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes (2015) 2.21
A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. Diabetologia (2015) 2.02
pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes (2013) 1.70
Antibiotics in early life alter the gut microbiome and increase disease incidence in a spontaneous mouse model of autoimmune insulin-dependent diabetes. PLoS One (2015) 1.63
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol (2017) 1.43
Th17 cells in immunity and autoimmunity. Clin Dev Immunol (2013) 1.40
Fecal microbiota imbalance in Mexican children with type 1 diabetes. Sci Rep (2014) 1.10
Gut microbiota, probiotics and diabetes. Nutr J (2014) 1.06
The intestinal microbiome in type 1 diabetes. Clin Exp Immunol (2014) 1.02
Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS One (2013) 1.00
Can exposure to environmental chemicals increase the risk of diabetes type 1 development? Biomed Res Int (2015) 0.99
Peripheral education of the immune system by the colonic microbiota. Semin Immunol (2013) 0.97
Deciphering the tête-à-tête between the microbiota and the immune system. J Clin Invest (2014) 0.97
Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes. Diabetes Care (2014) 0.94
The role of the intestinal microbiota in type 1 diabetes mellitus. Nat Rev Endocrinol (2016) 0.93
Microbiome-wide association studies link dynamic microbial consortia to disease. Nature (2016) 0.93
Microbiota and autoimmunity: exploring new avenues. Cell Host Microbe (2015) 0.93
Towards microbial fermentation metabolites as markers for health benefits of prebiotics. Nutr Res Rev (2015) 0.91
Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes. Front Microbiol (2014) 0.91
Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases. Clin Transl Immunology (2016) 0.91
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol (2016) 0.90
Gut microbiota and type 1 diabetes. Rev Diabet Stud (2012) 0.89
Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. J Exp Med (2016) 0.87
The gut microbiota and Type 1 Diabetes. Clin Immunol (2015) 0.87
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Rev Endocr Metab Disord (2015) 0.86
Gut microbial markers are associated with diabetes onset, regulatory imbalance, and IFN-γ level in NOD mice. Gut Microbes (2015) 0.86
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Clin Med Insights Pediatr (2016) 0.84
The changing landscape of type 1 diabetes: recent developments and future frontiers. Curr Diab Rep (2013) 0.83
The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate? Eur J Clin Nutr (2016) 0.83
American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome. Diabetes (2015) 0.82
Type 1 diabetes and celiac disease: clinical overlap and new insights into disease pathogenesis. Curr Diab Rep (2014) 0.82
Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs. J Immunol (2015) 0.82
Altered CD161 bright CD8+ mucosal associated invariant T (MAIT)-like cell dynamics and increased differentiation states among juvenile type 1 diabetics. PLoS One (2015) 0.81
The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice. PLoS One (2014) 0.81
Helicobacter pylori infection is associated with an altered gastric microbiota in children. Mucosal Immunol (2017) 0.81
Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatr (2013) 0.80
Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients (2015) 0.80
The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept? Pediatr Diabetes (2015) 0.80
Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals. Nutr Metab (Lond) (2014) 0.80
The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients (2015) 0.79
Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A (2017) 0.79
Host-Microbiota Interactions in the Pathogenesis of Antibiotic-Associated Diseases. Cell Rep (2016) 0.79
The gut microbiome in autoimmunity: Sex matters. Clin Immunol (2015) 0.79
Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics. ISME J (2017) 0.78
Recent advances in understanding Type 1 Diabetes. F1000Res (2016) 0.78
Mucosa-Associated Faecalibacterium prausnitzii Phylotype Richness Is Reduced in Patients with Inflammatory Bowel Disease. Appl Environ Microbiol (2015) 0.78
Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology (2017) 0.78
Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children. Proc Natl Acad Sci U S A (2017) 0.77
The role of beneficial bacteria wall elasticity in regulating innate immune response. EPMA J (2015) 0.77
Roles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic Pathologies. J Diabetes Res (2015) 0.77
Intestinal microbiota and anastomotic leakage of stapled colorectal anastomoses: a pilot study. Surg Endosc (2015) 0.77
Type 1 diabetes and gut microbiota: Friend or foe? Pharmacol Res (2015) 0.77
Lactobacillus rhamnosus GG Intake Modifies Preschool Children's Intestinal Microbiota, Alleviates Penicillin-Associated Changes, and Reduces Antibiotic Use. PLoS One (2016) 0.77
Tiny microbes, enormous impacts: what matters in gut microbiome studies? Genome Biol (2016) 0.76
Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4. PLoS One (2015) 0.76
Towards a functional hypothesis relating anti-islet cell autoimmunity to the dietary impact on microbial communities and butyrate production. Microbiome (2016) 0.76
Microbiota, Immune Subversion, and Chronic Inflammation. Front Immunol (2017) 0.75
Oligofructose as an adjunct in treatment of diabetes in NOD mice. Sci Rep (2016) 0.75
Targeting gut microbiota: a potential promising therapy for diabetic kidney disease. Am J Transl Res (2016) 0.75
Antibiotics, gut microbiota, environment in early life and type 1 diabetes. Pharmacol Res (2017) 0.75
Paediatrics: differences in the faecal microbiota of children with β-cell autoimmunity. Nat Rev Endocrinol (2013) 0.75
Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. J Exp Med (2016) 0.75
Endocrine manifestations in celiac disease. World J Gastroenterol (2016) 0.75
Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults. Front Immunol (2017) 0.75
Genistein prevention of hyperglycemia and improvement of glucose tolerance in adult non-obese diabetic mice are associated with alterations of gut microbiome and immune homeostasis. Toxicol Appl Pharmacol (2017) 0.75
Organ-specific protection mediated by cooperation between vascular and epithelial barriers. Nat Rev Immunol (2017) 0.75
Early-Life Nutritional Factors and Mucosal Immunity in the Development of Autoimmune Diabetes. Front Immunol (2017) 0.75
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The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res (2008) 52.43
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SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB. Nucleic Acids Res (2007) 35.65
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A (2010) 15.22
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A (2008) 14.18
Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity (2009) 8.95
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Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags. BMC Microbiol (2010) 4.97
Improved extraction of PCR-quality community DNA from digesta and fecal samples. Biotechniques (2004) 4.72
Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med (2010) 4.16
Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA (2003) 4.00
Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia (2006) 3.21
The role of microbiota in infectious disease. Trends Microbiol (2008) 3.11
Toward defining the autoimmune microbiome for type 1 diabetes. ISME J (2010) 3.03
The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes (2008) 2.77
Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol (2004) 2.66
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One (2011) 2.18
Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine. Appl Environ Microbiol (2002) 2.08
Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A (2005) 2.06
The enteric toxins of Clostridium perfringens. Rev Physiol Biochem Pharmacol (2004) 1.99
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr (2009) 1.94
Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut (2000) 1.92
Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples. Appl Environ Microbiol (2011) 1.76
Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model. ISME J (2009) 1.74
Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS One (2010) 1.70
Autoimmune mechanisms in type 1 diabetes. Autoimmun Rev (2008) 1.55
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Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes (1999) 1.32
Influence of major histocompatibility complex on bacterial composition of fecal flora. Infect Immun (2001) 1.27
Fructans in the diet cause alterations of intestinal mucosal architecture, released mucins and mucosa-associated bifidobacteria in gnotobiotic rats. Br J Nutr (2003) 1.26
Amount and avidity of salivary and serum antibodies against Streptococcus mutans in two groups of human subjects with different dental caries susceptibility. Infect Immun (1984) 1.15
Islet beta-cell-specific T cells can use different homing mechanisms to infiltrate and destroy pancreatic islets. Am J Pathol (2007) 1.07
HLA class II associated risk and protection against multiple sclerosis-a Finnish family study. J Neuroimmunol (2002) 1.07
Risk factors of development of gut-derived bacterial translocation in thermally injured rats. World J Gastroenterol (2004) 1.06
Modulation of gut mucosal biofilms. Br J Nutr (2005) 1.03
Interactions mediating bacterial translocation in the immature intestine. J Nutr (2000) 1.02
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Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study. Arch Pediatr Adolesc Med (2012) 1.01
Geographical variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity in a high-incidence country. Diabetes Care (2004) 0.95
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The gut as a regulator of early inflammation in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes (2011) 0.89
Does the intestinal bifidobacterial colonisation affect bacterial translocation? Anaerobe (2007) 0.86
Butyrate and type 1 diabetes mellitus: can we fix the intestinal leak? J Pediatr Gastroenterol Nutr (2010) 0.84
Prevalence of Celiac disease among children in Finland. N Engl J Med (2003) 7.27
GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med (2008) 5.74
Delay to institution of therapy and induction of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoid arthritis. Arthritis Rheum (2002) 4.77
Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med (2010) 4.16
Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol (2002) 3.71
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA (2013) 3.65
Toward defining the autoimmune microbiome for type 1 diabetes. ISME J (2010) 3.03
Environmental triggers and determinants of type 1 diabetes. Diabetes (2005) 2.93
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med (2008) 2.79
Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology (2002) 2.71
AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One (2012) 2.67
The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes (2011) 2.44
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes. PLoS One (2011) 2.18
A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J Allergy Clin Immunol (2004) 2.12
Recombination in circulating enteroviruses. J Virol (2003) 2.08
Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy. J Allergy Clin Immunol (2004) 1.96
Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand J Gastroenterol (2005) 1.85
Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr (2003) 1.76
Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system. Appl Environ Microbiol (2003) 1.74
Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments. J Clin Endocrinol Metab (2007) 1.68
Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland. Emerg Infect Dis (2012) 1.67
IL-17 immunity in human type 1 diabetes. J Immunol (2010) 1.67
IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm Bowel Dis (2008) 1.66
Timing of infant feeding in relation to childhood asthma and allergic diseases. J Allergy Clin Immunol (2012) 1.62
Infections in infants fed formula supplemented with bovine milk fat globule membranes. J Pediatr Gastroenterol Nutr (2015) 1.61
Serum insulin and leptin levels in valproate-associated obesity. Epilepsia (2002) 1.60
Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes (2009) 1.59
Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions. J Gen Virol (2005) 1.58
Parental reactions to information about increased genetic risk of type 1 diabetes mellitus in infants. Arch Pediatr Adolesc Med (2006) 1.55
Models for predicting type 1 diabetes in siblings of affected children. Diabetes Care (2006) 1.55
Vitamin D receptor polymorphisms: no association with type 1 diabetes in the Finnish population. Eur J Endocrinol (2003) 1.49
Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae. EMBO Rep (2001) 1.48
Prevalence and fate of type 1 diabetes-associated autoantibodies in cord blood samples from newborn infants of non-diabetic mothers. Diabetes Metab Res Rev (2002) 1.47
Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes (2013) 1.47
Fecal microbiota composition and frailty. Appl Environ Microbiol (2005) 1.46
Dietary risk factors for the emergence of type 1 diabetes-related autoantibodies in 21/2 year-old Swedish children. Br J Nutr (2006) 1.46
Lower economic status and inferior hygienic environment may protect against celiac disease. Ann Med (2008) 1.39
Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes (2003) 1.38
Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe (2011) 1.38
Molecular diversity, cultivation, and improved detection by fluorescent in situ hybridization of a dominant group of human gut bacteria related to Roseburia spp. or Eubacterium rectale. Appl Environ Microbiol (2006) 1.38
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes. Diabetes (2013) 1.34
Environmental factors in the etiology of type 1 diabetes. Am J Med Genet (2002) 1.33
Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes. Diabetes (2013) 1.30
The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environ Microbiol (2008) 1.28
Ketoacidosis at diagnosis of type 1 diabetes in children in northern Finland: temporal changes over 20 years. Diabetes Care (2007) 1.27
Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects. Br J Nutr (2010) 1.27
Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes (2010) 1.26
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun (2005) 1.26
A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther (2007) 1.23
Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study. J Med Virol (2003) 1.22
The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia (2015) 1.20
Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia (2009) 1.19
Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients. Intensive Care Med (2010) 1.18
Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies. Diabetes Care (2006) 1.16
Incidence of type 1 diabetes in Finland. JAMA (2013) 1.15
Advanced glycation end products are direct modulators of β-cell function. Diabetes (2011) 1.14
Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant. J Autoimmun (2008) 1.13
Dietary intake and use of dietary supplements in relation to demographic variables among pregnant Finnish women. Br J Nutr (2006) 1.12
Aberrant gut microbiota composition at the onset of type 1 diabetes in young children. Diabetologia (2014) 1.12
Incipient angiogenesis in Barrett's epithelium and lymphangiogenesis in Barrett's adenocarcinoma. J Clin Oncol (2002) 1.11
Reduced prevalence of diabetic ketoacidosis at diagnosis of type 1 diabetes in young children participating in longitudinal follow-up. Diabetes Care (2011) 1.11
Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet (2002) 1.10
Age at the introduction of solid foods during the first year and allergic sensitization at age 5 years. Pediatrics (2009) 1.10
Genetic risk determines the emergence of diabetes-associated autoantibodies in young children. Diabetes (2002) 1.10
Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population. Br J Nutr (2007) 1.08
Other complications and associated conditions with diabetes in children and adolescents. Pediatr Diabetes (2009) 1.07
HLA class II associated risk and protection against multiple sclerosis-a Finnish family study. J Neuroimmunol (2002) 1.07