Published in Angew Chem Int Ed Engl on January 02, 2013
Rational reprogramming of fungal polyketide first-ring cyclization. Proc Natl Acad Sci U S A (2013) 1.02
Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases. Proc Natl Acad Sci U S A (2014) 0.95
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. J Am Chem Soc (2014) 0.92
Steps towards the synthetic biology of polyketide biosynthesis. FEMS Microbiol Lett (2014) 0.91
Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis. J Am Chem Soc (2013) 0.90
Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases. Org Lett (2014) 0.89
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA. ACS Chem Biol (2015) 0.86
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Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes. Angew Chem Int Ed Engl (2016) 0.76
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin. Cell Chem Biol (2017) 0.75
Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes. Angew Chem Weinheim Bergstr Ger (2016) 0.75
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The crystal structure of a mammalian fatty acid synthase. Science (2008) 3.12
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans. Chem Biol (2001) 2.35
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature (2009) 1.94
New insights into the formation of fungal aromatic polyketides. Nat Rev Microbiol (2010) 1.59
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. Chem Biol (1999) 1.51
Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase. Chem Biol (2009) 1.48
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. J Am Chem Soc (2012) 1.29
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem (2008) 1.16
Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc (2011) 1.08
Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chem Biol (2012) 0.94
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chem Commun (Camb) (2012) 0.93
Fungal type I polyketide synthases. Methods Enzymol (2009) 0.91
Pannorin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor produced by Chrysosporium pannorum. J Antibiot (Tokyo) (1991) 0.89
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. J Mol Biol (2002) 2.41
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol (2010) 2.04
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature (2009) 1.94
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science (2012) 1.82
Quantitative proteomic analysis of drug-induced changes in mycobacteria. J Proteome Res (2006) 1.69
An externally tunable bacterial band-pass filter. Proc Natl Acad Sci U S A (2009) 1.67
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res (2003) 1.65
New insights into the formation of fungal aromatic polyketides. Nat Rev Microbiol (2010) 1.59
Polyketide proofreading by an acyltransferase-like enzyme. Chem Biol (2012) 1.57
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res (2007) 1.51
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1). Chem Biol (2002) 1.47
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol (2013) 1.47
Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am J Physiol Endocrinol Metab (2002) 1.32
Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorg Chem (2008) 1.32
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. J Am Chem Soc (2012) 1.29
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.25
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem (2008) 1.16
Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules. J Am Chem Soc (2014) 1.14
Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. J Am Chem Soc (2007) 1.12
Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors. J Med Chem (2009) 1.11
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites. J Am Chem Soc (2005) 1.07
Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. J Am Chem Soc (2009) 1.06
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.06
Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem Biol (2010) 1.06
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis. J Am Chem Soc (2002) 1.02
Simple, rapid procedure for the synthesis of chloromethyl methyl ether and other chloro alkyl ethers. J Org Chem (2005) 1.02
The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proc Natl Acad Sci U S A (2002) 1.02
Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem. J Am Chem Soc (2003) 1.02
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. Am J Physiol Regul Integr Comp Physiol (2007) 1.00
Crystal structure of carbapenam synthetase (CarA). J Biol Chem (2003) 1.00
Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora. Biochemistry (2003) 1.00
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proc Natl Acad Sci U S A (2012) 0.99
Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. J Med Chem (2005) 0.99
Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. J Biol Chem (2008) 0.99
Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI. J Am Chem Soc (2013) 0.98
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. J Am Chem Soc (2003) 0.96
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A. Chem Biol (2004) 0.95
Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol (2011) 0.95
Role of the cytochrome P450 NocL in nocardicin A biosynthesis. J Am Chem Soc (2002) 0.95
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng (2006) 0.94
Merging chemical ecology with bacterial genome mining for secondary metabolite discovery. J Ind Microbiol Biotechnol (2013) 0.94
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics. J Am Chem Soc (2010) 0.94
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry (2004) 0.94
Effect of n-octanesulphonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. J Antimicrob Chemother (2004) 0.94
Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways. Appl Environ Microbiol (2015) 0.94
Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chem Biol (2012) 0.94
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chem Commun (Camb) (2012) 0.93
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. J Am Chem Soc (2014) 0.92
Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis. J Bacteriol (2005) 0.92
Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase. Chembiochem (2012) 0.92
Distribution and sub-cellular localization of the aflatoxin enzyme versicolorin B synthase in time-fractionated colonies of Aspergillus parasiticus. Arch Microbiol (2004) 0.91
Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem (2011) 0.90
A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Org Lett (2002) 0.90
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proc Natl Acad Sci U S A (2013) 0.89
Active site comparisons and catalytic mechanisms of the hot dog superfamily. Chem Rev (2012) 0.89
Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin. J Am Chem Soc (2005) 0.88
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry (2009) 0.88
Stereocontrolled syntheses of peptide thioesters containing modified seryl residues as probes of antibiotic biosynthesis. J Org Chem (2013) 0.87
In vivo characterization of nonribosomal peptide synthetases NocA and NocB in the biosynthesis of nocardicin A. Chem Biol (2012) 0.86
Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase. Biochemistry (2007) 0.86
DNA interstrand cross-linking by epichlorohydrin. Chem Res Toxicol (2007) 0.85
A conserved lysine in beta-lactam synthetase assists ring cyclization: Implications for clavam and carbapenem biosynthesis. Chembiochem (2009) 0.84
A catalytic asymmetric route to carbapenems. Org Lett (2009) 0.83
Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily. Biochemistry (2004) 0.83
Mutational analysis and characterization of nocardicin C-9' epimerase. J Biol Chem (2004) 0.82
Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. Chembiochem (2008) 0.82
Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed octaketide on the enediyne polyketide synthase CalE8. J Am Chem Soc (2013) 0.82
Autoproteolytic activation of ThnT results in structural reorganization necessary for substrate binding and catalysis. J Mol Biol (2012) 0.81
Metabolic engineering of the E. coli L-phenylalanine pathway for the production of D-phenylglycine (D-Phg). Metab Eng (2006) 0.81
Mechanistic insights into the bifunctional non-heme iron oxygenase carbapenem synthase by active site saturation mutagenesis. J Am Chem Soc (2013) 0.80
A high-throughput screen for the engineered production of β-lactam antibiotics. ACS Chem Biol (2012) 0.80
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009. Chembiochem (2014) 0.80
A practical route to substituted 7-aminoindoles from pyrrole-3-carboxaldehydes. Org Lett (2014) 0.79
Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors. Bioorg Med Chem (2010) 0.79
Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis. Angew Chem Int Ed Engl (2012) 0.79
Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis. J Bacteriol (2008) 0.79
Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. FEMS Microbiol Lett (2010) 0.77
Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug. Bioorg Med Chem Lett (2008) 0.76
Exploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT. Biochemistry (2014) 0.75
New alpha-methylene-gamma-butyrolactones with antimycobacterial properties. Bioorg Med Chem Lett (2005) 0.75
Enzymology: Modular biosynthesis branches out. Nature (2013) 0.75
Biosynthesis: not just passing through. Nat Chem (2010) 0.75
New images evoke FAScinating questions. Chem Biol (2006) 0.75
Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA. Mutat Res (2009) 0.75
Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics. Medchemcomm (2012) 0.75
A convergent approach to the total synthesis of telmisartan via a Suzuki cross-coupling reaction between two functionalized benzimidazoles. J Org Chem (2015) 0.75