Published in J Biol Chem on July 30, 2003
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Philos Trans R Soc Lond B Biol Sci (2007) 1.25
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.06
Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. J Biol Chem (2008) 0.99
Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. Structure (2009) 0.96
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem (2011) 0.94
Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem (2011) 0.90
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry (2009) 0.88
Rate-limiting steps and role of active site Lys443 in the mechanism of carbapenam synthetase. Biochemistry (2007) 0.86
Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem (2010) 0.83
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009. Chembiochem (2014) 0.80
Identification and Characterization of the Sulfazecin Monobactam Biosynthetic Gene Cluster. Cell Chem Biol (2016) 0.77
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry (2010) 0.75
Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics. Medchemcomm (2012) 0.75
Quorum Sensing Attenuates Virulence in Sodalis praecaptivus. Cell Host Microbe (2017) 0.75
Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane. Nature (2005) 3.43
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase. J Mol Biol (2002) 2.41
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
The biochemistry of methane oxidation. Annu Rev Biochem (2007) 2.12
Oxidation of methane by a biological dicopper centre. Nature (2010) 2.09
Structural basis for activation of class Ib ribonucleotide reductase. Science (2010) 2.07
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature (2009) 1.94
Structural biology of copper trafficking. Chem Rev (2009) 1.89
Quantitative proteomic analysis of drug-induced changes in mycobacteria. J Proteome Res (2006) 1.69
An externally tunable bacterial band-pass filter. Proc Natl Acad Sci U S A (2009) 1.67
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res (2003) 1.65
Structural basis for methyl transfer by a radical SAM enzyme. Science (2011) 1.61
New insights into the formation of fungal aromatic polyketides. Nat Rev Microbiol (2010) 1.59
Polyketide proofreading by an acyltransferase-like enzyme. Chem Biol (2012) 1.57
Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster. Proc Natl Acad Sci U S A (2003) 1.54
Cu(I) binding and transfer by the N terminus of the Wilson disease protein. J Biol Chem (2007) 1.52
Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res (2007) 1.51
Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorg Chem (2006) 1.50
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1). Chem Biol (2002) 1.47
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol (2013) 1.47
Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase. Acc Chem Res (2007) 1.44
Structure of the ATP binding domain from the Archaeoglobus fulgidus Cu+-ATPase. J Biol Chem (2006) 1.41
The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry (2008) 1.38
Copper methanobactin: a molecule whose time has come. Curr Opin Chem Biol (2008) 1.33
Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am J Physiol Endocrinol Metab (2002) 1.32
Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorg Chem (2008) 1.32
Biological methane oxidation: regulation, biochemistry, and active site structure of particulate methane monooxygenase. Crit Rev Biochem Mol Biol (2004) 1.30
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. J Am Chem Soc (2012) 1.29
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.25
Structure and metal binding properties of ZnuA, a periplasmic zinc transporter from Escherichia coli. J Biol Inorg Chem (2007) 1.25
Crystal structures of cisplatin bound to a human copper chaperone. J Am Chem Soc (2009) 1.23
The copper chelator methanobactin from Methylosinus trichosporium OB3b binds copper(I). J Am Chem Soc (2005) 1.23
Binding of copper(I) by the Wilson disease protein and its copper chaperone. J Biol Chem (2004) 1.23
Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1. Biochemistry (2008) 1.18
Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol (2009) 1.17
The quest for the particulate methane monooxygenase active site. Dalton Trans (2005) 1.17
Probing transient copper chaperone-Wilson disease protein interactions at the single-molecule level with nanovesicle trapping. J Am Chem Soc (2008) 1.17
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem (2008) 1.16
Structures of the yeast ribonucleotide reductase Rnr2 and Rnr4 homodimers. Biochemistry (2004) 1.13
Chemistry and biology of the copper chelator methanobactin. ACS Chem Biol (2011) 1.13
Architecture and active site of particulate methane monooxygenase. Crit Rev Biochem Mol Biol (2012) 1.12
Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. J Am Chem Soc (2007) 1.12
Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog. Appl Environ Microbiol (2009) 1.12
Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors. J Med Chem (2009) 1.11
Structure of the actuator domain from the Archaeoglobus fulgidus Cu(+)-ATPase. Biochemistry (2006) 1.10
Crystal structure and characterization of particulate methane monooxygenase from Methylocystis species strain M. Biochemistry (2011) 1.09
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites. J Am Chem Soc (2005) 1.07
Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for the biosynthesis of enediyne core structures. J Am Chem Soc (2009) 1.06
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.06
Yeast cox17 solution structure and Copper(I) binding. J Biol Chem (2004) 1.06
Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products. Angew Chem Int Ed Engl (2013) 1.03
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis. J Am Chem Soc (2002) 1.02
The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proc Natl Acad Sci U S A (2002) 1.02
Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem. J Am Chem Soc (2003) 1.02
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight. Am J Physiol Regul Integr Comp Physiol (2007) 1.00
Inhibition and alternate substrate studies on the mechanism of carbapenam synthetase from Erwinia carotovora. Biochemistry (2003) 1.00
Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2. J Am Chem Soc (2003) 1.00
Crystal structure of yeast Sco1. J Biol Inorg Chem (2006) 1.00
Crystal structure of a two-domain multicopper oxidase: implications for the evolution of multicopper blue proteins. J Biol Chem (2009) 1.00
Evidence for oxygen binding at the active site of particulate methane monooxygenase. J Am Chem Soc (2012) 1.00
Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. J Med Chem (2005) 0.99
Dynamic docking of cytochrome b5 with myoglobin and alpha-hemoglobin: heme-neutralization "squares" and the binding of electron-transfer-reactive configurations. J Am Chem Soc (2007) 0.99
Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proc Natl Acad Sci U S A (2012) 0.99
Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. J Biol Chem (2008) 0.99
Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI. J Am Chem Soc (2013) 0.98
Characterization and structure of a Zn2+ and [2Fe-2S]-containing copper chaperone from Archaeoglobus fulgidus. J Biol Chem (2007) 0.97
X-ray crystallography and biological metal centers: is seeing believing? Inorg Chem (2005) 0.97
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase. Nat Struct Mol Biol (2009) 0.97
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline. J Am Chem Soc (2003) 0.96
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A. Chem Biol (2004) 0.95
Role of the cytochrome P450 NocL in nocardicin A biosynthesis. J Am Chem Soc (2002) 0.95
Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity. Am J Physiol Regul Integr Comp Physiol (2011) 0.95
Crystal structure and dimerization equilibria of PcoC, a methionine-rich copper resistance protein from Escherichia coli. J Biol Inorg Chem (2002) 0.95
Structure and ligand binding properties of the epoxidase component of styrene monooxygenase . Biochemistry (2010) 0.94
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng (2006) 0.94
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics. J Am Chem Soc (2010) 0.94
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry (2004) 0.94
Effect of n-octanesulphonylacetamide (OSA) on ATP and protein expression in Mycobacterium bovis BCG. J Antimicrob Chemother (2004) 0.94
Diversity of the metal-transporting P1B-type ATPases. J Biol Inorg Chem (2014) 0.94
Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis. Chem Biol (2012) 0.94
Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. Chem Commun (Camb) (2012) 0.93
Evidence that the β subunit of Chlamydia trachomatis ribonucleotide reductase is active with the manganese ion of its manganese(IV)/iron(III) cofactor in site 1. J Am Chem Soc (2012) 0.93
Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming. J Am Chem Soc (2014) 0.92
Mutational analysis of nocK and nocL in the nocardicin a producer Nocardia uniformis. J Bacteriol (2005) 0.92
Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase. Chembiochem (2012) 0.92
Mechanism of the C5 stereoinversion reaction in the biosynthesis of carbapenem antibiotics. Science (2014) 0.91
Dual pathways for copper uptake by methanotrophic bacteria. J Biol Chem (2011) 0.91
Structure of the redox sensor domain of Methylococcus capsulatus (Bath) MmoS. Biochemistry (2009) 0.91
Distribution and sub-cellular localization of the aflatoxin enzyme versicolorin B synthase in time-fractionated colonies of Aspergillus parasiticus. Arch Microbiol (2004) 0.91
Definition of the common and divergent steps in carbapenem β-lactam antibiotic biosynthesis. Chembiochem (2011) 0.90
Identification of a hemerythrin-like domain in a P1B-type transport ATPase. Biochemistry (2010) 0.90
Genome mining for methanobactins. BMC Biol (2013) 0.90
A flexible route to (5R)-thiolactomycin, a naturally occurring inhibitor of fatty acid synthesis. Org Lett (2002) 0.90
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proc Natl Acad Sci U S A (2013) 0.89
Active site comparisons and catalytic mechanisms of the hot dog superfamily. Chem Rev (2012) 0.89
Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin. J Am Chem Soc (2005) 0.88
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry (2009) 0.88