A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model.

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Published in Clin Vaccine Immunol on January 16, 2013

Authors

Nicola L Davies1, Joanne E Compson, Brendon Mackenzie, Victoria L O'Dowd, Amanda K F Oxbrow, James T Heads, Alison Turner, Kaushik Sarkar, Sarah L Dugdale, Mark Jairaj, Louis Christodoulou, David E O Knight, Amanda S Cross, Karine J M Hervé, Kerry L Tyson, Hanna Hailu, Carl B Doyle, Mark Ellis, Marco Kriek, Matthew Cox, Matthew J T Page, Adrian R Moore, Daniel J Lightwood, David P Humphreys

Author Affiliations

1: Discovery Biology, UCB Pharma Slough, Slough, Berkshire, United Kingdom.

Associated clinical trials:

A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) (MODIFY I) | NCT01241552

A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002) (MODIFY II) | NCT01513239

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