Published in Infect Immun on May 16, 2011
A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun (2012) 1.22
Fidaxomicin inhibits spore production in Clostridium difficile. Clin Infect Dis (2012) 1.15
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model. Antimicrob Agents Chemother (2012) 1.03
A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model. Clin Vaccine Immunol (2013) 1.03
Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrob Agents Chemother (2012) 0.99
Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches. Front Microbiol (2015) 0.97
Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect Immun (2014) 0.94
Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun (2014) 0.91
Prevention of Clostridium difficile spore formation by sub-inhibitory concentrations of tigecycline and piperacillin/tazobactam. BMC Infect Dis (2014) 0.88
Antibodies for treatment of Clostridium difficile infection. Clin Vaccine Immunol (2014) 0.87
Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice. Gut Pathog (2012) 0.87
Clostridium difficile drug pipeline: challenges in discovery and development of new agents. J Med Chem (2015) 0.86
MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile. Antimicrob Agents Chemother (2012) 0.85
Novel riboswitch-binding flavin analog that protects mice against Clostridium difficile infection without inhibiting cecal flora. Antimicrob Agents Chemother (2015) 0.84
Protection from Clostridium difficile infection in CD4 T Cell- and polymeric immunoglobulin receptor-deficient mice. Infect Immun (2013) 0.83
Humanized microbiota mice as a model of recurrent Clostridium difficile disease. Microbiome (2015) 0.82
Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment. BMC Infect Dis (2012) 0.82
The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection. Mol Immunol (2014) 0.81
Fate of ingested Clostridium difficile spores in mice. PLoS One (2013) 0.80
The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice. Immunology (2015) 0.80
Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment. Antimicrob Agents Chemother (2015) 0.80
Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC. Emerg Microbes Infect (2016) 0.80
Treatment of Clostridium difficile infection in mice with vancomycin alone is as effective as treatment with vancomycin and metronidazole in combination. BMJ Open Gastroenterol (2015) 0.80
The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain. Anaerobe (2015) 0.79
Intestinal epithelial restitution after TcdB challenge and recovery from Clostridium difficile infection in mice with alanyl-glutamine treatment. J Infect Dis (2013) 0.79
Using a Novel Lysin To Help Control Clostridium difficile Infections. Antimicrob Agents Chemother (2015) 0.78
A Detrimental Role of Immunosuppressive Drug, Dexamethasone, During Clostridium difficile Infection in Association with a Gastrointestinal Microbial Shift. J Microbiol Biotechnol (2016) 0.78
Semiquantitative analysis of clinical heat stress in Clostridium difficile strain 630 using a GeLC/MS workflow with emPAI quantitation. PLoS One (2014) 0.77
A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters. Hum Vaccin Immunother (2015) 0.77
Newly identified bacteriolytic enzymes that target a wide range of clinical isolates of Clostridium difficile. Biotechnol Bioeng (2016) 0.76
Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe (2015) 0.75
Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model. Evid Based Complement Alternat Med (2016) 0.75
Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute Clostridium difficile Infection. J Vaccines Vaccin (2016) 0.75
Protective Effect of Carvacrol against Gut Dysbiosis and Clostridium difficile Associated Disease in a Mouse Model. Front Microbiol (2017) 0.75
An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med (2005) 18.10
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med (2005) 16.59
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis (2007) 8.65
Clinical practice. Antibiotic-associated diarrhea. N Engl J Med (2002) 7.13
Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med (2000) 6.24
Effects of Clostridium difficile toxins given intragastrically to animals. Infect Immun (1985) 5.44
Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med (2006) 4.64
Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet (2001) 4.59
A mouse model of Clostridium difficile-associated disease. Gastroenterology (2008) 3.65
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36
Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease. Am J Gastroenterol (2002) 3.24
Antibiotic-associated colitis: effects of antibiotics on Clostridium difficile and the disease in hamsters. Rev Infect Dis (1980) 2.59
Epidemiology of recurrences or reinfections of Clostridium difficile-associated diarrhea. J Clin Microbiol (2000) 2.42
Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes. J Infect (2009) 2.33
Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters. Infect Immun (2006) 2.09
Recurrences of Clostridium difficile diarrhea not caused by the original infecting organism. J Infect Dis (1989) 2.08
Recurrence of symptoms in Clostridium difficile infection--relapse or reinfection? J Hosp Infect (1998) 2.00
Clostridium difficile colitis associated with chronic renal failure. Nephrol Dial Transplant (1998) 1.94
Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol (2010) 1.82
Pathogenesis of Clostridium difficile infection. J Antimicrob Chemother (1998) 1.72
Relapse versus reinfection with Clostridium difficile. Epidemiol Infect (1991) 1.69
Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection. Infect Immun (1994) 1.68
Antibodies to recombinant Clostridium difficile toxins A and B are an effective treatment and prevent relapse of C. difficile-associated disease in a hamster model of infection. Infect Immun (1998) 1.63
Ascites associated with antibiotic-associated pseudomembranous colitis. South Med J (1996) 1.51
Pseudomembranous colitis in Clostridium difficile-monoassociated rats. Infect Immun (1983) 1.51
Update on Clostridium difficile associated disease. Curr Opin Gastroenterol (2007) 1.44
Piglet models of acute or chronic Clostridium difficile illness. J Infect Dis (2010) 1.38
Mucosal damage mediated by clostridial toxin in experimental clindamycin-associated colitis. Gut (1980) 1.37
An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. J Microbiol Methods (2009) 1.34
Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strain. J Infect Dis (2010) 1.19
Molecular analysis of Clostridium difficile strains isolated from 18 cases of recurrent clostridium difficile-associated diarrhea. J Clin Microbiol (2003) 1.19
Recurrent Clostridium difficile infection: causality and therapeutic approaches. Int J Antimicrob Agents (2009) 1.14
Pathogenesis and treatment of Clostridium difficile infection. Postgrad Med J (2005) 1.04
Clindamycin-associated enterocolitis in guinea pigs: evidence for a bacterial toxin. Infect Immun (1979) 1.04
Liver abscess caused by Clostridium difficile. Scand J Infect Dis (2001) 0.95
Severe pseudomembranous enterocolitis in a child: case report and literature review. Pediatr Infect Dis J (1989) 0.94
Pseudomembranous colitis: report of a severe case with unusual clinical signs in a young nurse. Dis Colon Rectum (2000) 0.93
[Epidemiology, risk factors and prevention of Clostridium difficile nosocomial infections]. Pathol Biol (Paris) (2000) 0.77
Comparative metagenomics of microbial communities. Science (2005) 25.88
A genome-wide map of conserved microRNA targets in C. elegans. Curr Biol (2006) 10.14
The landscape of C. elegans 3'UTRs. Science (2010) 3.32
Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol (2012) 3.09
Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke (2012) 2.88
Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci U S A (2008) 2.73
A transient placental source of serotonin for the fetal forebrain. Nature (2011) 2.71
Use of qigong therapy in the detoxification of heroin addicts. Altern Ther Health Med (2002) 2.28
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. J Comp Neurol (2007) 2.17
Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1). Mol Cell Biol (2006) 2.02
Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models. J Infect Dis (2011) 1.98
Multiple SVM-RFE for gene selection in cancer classification with expression data. IEEE Trans Nanobioscience (2005) 1.91
Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium. BMC Microbiol (2008) 1.89
Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology (2010) 1.83
Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med (2012) 1.82
rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China. J Clin Microbiol (2006) 1.68
Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease. Exp Neurol (2006) 1.64
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev (2008) 1.56
Melanoma-specific marker expression in skin biopsy tissues as a tool to facilitate melanoma diagnosis. J Invest Dermatol (2010) 1.52
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A (2006) 1.46
Quantitative, spatial resolution of the epigenetic field effect in prostate cancer. Prostate (2008) 1.46
Bilateral stereotactic radiofrequency amygdalohippocampectomy for a patient with bilateral temporal lobe epilepsy. Epilepsia (2013) 1.40
Piglet models of acute or chronic Clostridium difficile illness. J Infect Dis (2010) 1.38
An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. J Microbiol Methods (2009) 1.34
Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res (2009) 1.32
TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.31
Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus. Mol Carcinog (2003) 1.30
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment. Neoplasia (2009) 1.27
Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci (2005) 1.26
Non-equilibrium allele frequency spectra via spectral methods. Theor Popul Biol (2011) 1.26
Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci (2005) 1.25
Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc Natl Acad Sci U S A (2013) 1.24
Rapid CT diagnosis of acute appendicitis with IV contrast material. Emerg Radiol (2005) 1.22
A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun (2012) 1.22
Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A. Infect Immun (2009) 1.21
Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport (2008) 1.21
Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem (2006) 1.20
Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat Med (2011) 1.19
Intracellular neutralization of shiga toxin 2 by an a subunit-specific human monoclonal antibody. Infect Immun (2008) 1.19
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue. Int J Cancer (2013) 1.16
Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury. Ann Neurol (2011) 1.15
Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. Hum Mol Genet (2006) 1.15
International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers. J Magn Reson Imaging (2010) 1.14
Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene. J Biol Chem (2004) 1.13
Perinatally administered bisphenol a as a potential mammary gland carcinogen in rats. Environ Health Perspect (2013) 1.13
Prevalence of nontuberculous mycobacteria infection, China, 2004-2009. Emerg Infect Dis (2012) 1.11
Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. Am J Hum Genet (2005) 1.10
Regulatory effects of hydrogen sulfide on IL-6, IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury. Exp Biol Med (Maywood) (2008) 1.08
Large-area compliant tactile sensors using printed carbon nanotube active-matrix backplanes. Adv Mater (2015) 1.07
The enterotoxicity of Clostridium difficile toxins. Toxins (Basel) (2010) 1.07
Correlating gene expression variation with cis-regulatory polymorphism in Saccharomyces cerevisiae. Genome Biol Evol (2010) 1.06
Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers. Cancer Immunol Immunother (2003) 1.05
Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal (2013) 1.04
Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res (2009) 1.04
Identifying sources and assessing potential risk of heavy metals in soils from direct exposure to children in a mine-impacted city, Changsha, China. J Environ Qual (2010) 1.03
Chromatin remodeling by DNA bending, not twisting. Proc Natl Acad Sci U S A (2005) 1.00
Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J (2009) 1.00
Tobacco use and dependence in Asian American and Pacific Islander adolescents: a review of the literature. J Ethn Subst Abuse (2007) 1.00
Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol (2005) 1.00
Laboratory-based surveillance of extensively drug-resistant tuberculosis, China. Emerg Infect Dis (2011) 0.99
Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology (2009) 0.99
Development of viral nanoparticles for efficient intracellular delivery. Nanoscale (2012) 0.99
Development of a multiplexed urine assay for prostate cancer diagnosis. Clin Chem (2008) 0.99
Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity. Blood (2003) 0.99
Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages. Microb Pathog (2009) 0.99
HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells. PLoS One (2008) 0.98
A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol (2005) 0.98
Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1. J Biol Chem (2002) 0.98
Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem (2003) 0.97
A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol Psychiatry (2009) 0.97
Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol (2012) 0.97
Relationship between self-reported task persistence and history of quitting smoking, plans for quitting smoking, and current smoking status in adolescents. Addict Behav (2006) 0.96
Trying to understand why horrible things happen: attribution, shame, and symptom development following sexual abuse. Child Maltreat (2002) 0.95
Permutation - based statistical tests for multiple hypotheses. Source Code Biol Med (2008) 0.95
Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors. Mol Endocrinol (2006) 0.94
Biomimetic entry to the sarpagan family of indole alkaloids: total synthesis of +-geissoschizine and +-N-methylvellosimine. J Am Chem Soc (2003) 0.94
Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem (2009) 0.94
Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology (2011) 0.94
Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling. J Biol Chem (2002) 0.93
A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One (2013) 0.93
A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug Metab Dispos (2003) 0.93
Short-term change in growth of uterine leiomyoma: tumor growth spurts. Fertil Steril (2010) 0.93
Potential health risk of arsenic and cadmium in groundwater near Xiangjiang River, China: a case study for risk assessment and management of toxic substances. Environ Monit Assess (2010) 0.93
Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. J Neurosci (2010) 0.92
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. J Biol Chem (2009) 0.92
Human piRNAs are under selection in Africans and repress transposable elements. Mol Biol Evol (2011) 0.92
Integration of genomic data for inferring protein complexes from global protein-protein interaction networks. IEEE Trans Syst Man Cybern B Cybern (2008) 0.91
5-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins. FASEB J (2011) 0.90
Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol. Pathog Dis (2013) 0.90
Use of environmental supports among patients with schizophrenia. Psychiatr Serv (2006) 0.90