Loss of HPV16 E2 Protein Expression Without Disruption of the E2 ORF Correlates with Carcinogenic Progression.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 3547325)

Published in Open Virol J on December 28, 2012

Authors

Yuezhen Xue1, Diana Lim, Liang Zhi, Pingping He, Jean-Pierre Abastado, Françoise Thierry

Author Affiliations

1: Institute of Medical Biology, 8A Biomedical grove, Immunos, ASTAR, 138648, Singapore.

Articles cited by this

Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol (2008) 15.90

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (1985) 11.11

Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J (1986) 7.60

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J Virol (1987) 6.65

Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer (2001) 3.61

The papillomavirus life cycle. J Clin Virol (2005) 3.41

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J Virol (1990) 2.90

Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci (2006) 2.56

Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract. Cancer Res (2004) 2.24

Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res (1999) 2.17

Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA. J Virol (1996) 1.91

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes Dev (2004) 1.90

Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers. J Virol (2003) 1.79

Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis. J Biol Chem (2005) 1.41

Transcriptional regulation of the papillomavirus oncogenes by cellular and viral transcription factors in cervical carcinoma. Virology (2008) 1.41

Integration of the HPV16 genome does not invariably result in high levels of viral oncogene transcripts. Oncogene (2007) 1.37

The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes. Cancer Res (2008) 1.30

Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma. J Pathol (2010) 1.30

HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma. Cancer Res (2010) 1.26

Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain. J Virol (2001) 1.19

Papillomavirus DNA replication - from initiation to genomic instability. Virology (2009) 1.15

Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. J Biol Chem (2011) 1.11

In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis. Cancer Res (2010) 1.10

A genomic approach reveals a novel mitotic pathway in papillomavirus carcinogenesis. Cancer Res (2004) 0.96

The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase. J Virol (2010) 0.93

Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res (2011) 0.91

The E2 protein of human papillomavirus type 16 is translated from a variety of differentially spliced polycistronic mRNAs. J Gen Virol (1999) 0.88

The HPV transcriptome in HPV16 positive cell lines. Mol Cell Probes (2011) 0.88

A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells. J Virol (2007) 0.87

Articles by these authors

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest (2010) 3.41

Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS One (2008) 2.28

Macrophage polarization to a unique phenotype driven by B cells. Eur J Immunol (2010) 2.25

Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes. J Virol (2005) 1.92

Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol (2011) 1.92

DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation. Blood (2003) 1.89

Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J Cell Biol (2006) 1.74

Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. Cancer Res (2011) 1.64

HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity (2002) 1.62

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma. Gut (2011) 1.56

Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients. J Hepatol (2009) 1.51

Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am J Physiol Lung Cell Mol Physiol (2006) 1.42

Nucleo-cytoplasmic shuttling of high risk human Papillomavirus E2 proteins induces apoptosis. J Biol Chem (2005) 1.41

Constrained intracellular survival of Mycobacterium tuberculosis in human dendritic cells. J Immunol (2003) 1.39

HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma. Cancer Res (2010) 1.26

Macrophages and cancer. Front Biosci (2008) 1.23

CC chemokine ligand 19 secreted by mature dendritic cells increases naive T cell scanning behavior and their response to rare cognate antigen. J Immunol (2005) 1.21

Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB. Am J Physiol Lung Cell Mol Physiol (2007) 1.19

Incidence, clinical features and impact on anti-tuberculosis treatment of anti-tuberculosis drug induced liver injury (ATLI) in China. PLoS One (2011) 1.18

Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein. Oncogene (2003) 1.17

Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J Leukoc Biol (2007) 1.17

Vaccination of melanoma patients using dendritic cells loaded with an allogeneic tumor cell lysate. Cancer Immunol Immunother (2005) 1.16

Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases. J Immunol (2008) 1.15

High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle (2005) 1.12

Chikungunya virus envelope-specific human monoclonal antibodies with broad neutralization potency. J Immunol (2011) 1.09

Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. Am J Physiol Lung Cell Mol Physiol (2006) 1.09

Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways. Am J Physiol Cell Physiol (2008) 1.06

A pivotal role for CXCL12 signaling in HPV-mediated transformation of keratinocytes: clues to understanding HPV-pathogenesis in WHIM syndrome. Cell Host Microbe (2010) 1.04

Dacarbazine promotes stromal remodeling and lymphocyte infiltration in cutaneous melanoma lesions. J Invest Dermatol (2011) 1.00

Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D. Blood (2013) 0.99

Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients. J Natl Cancer Inst (2012) 0.98

Ectopic cervical thymoma: a report of two cases of a rare entity frequently misdiagnosed on fine needle aspiration cytology and frozen section. Head Neck Pathol (2010) 0.98

HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo. J Clin Invest (2005) 0.97

Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses. BMC Genomics (2006) 0.97

DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells. J Virol (2006) 0.97

Expansion of cortical and medullary sinuses restrains lymph node hypertrophy during prolonged inflammation. J Immunol (2012) 0.95

Cell labeling approaches for fluorescence-based in vivo flow cytometry. Cytometry A (2011) 0.94

T cells contribute to tumor progression by favoring pro-tumoral properties of intra-tumoral myeloid cells in a mouse model for spontaneous melanoma. PLoS One (2011) 0.93

The human papillomavirus type 18 E2 protein is a cell cycle-dependent target of the SCFSkp2 ubiquitin ligase. J Virol (2010) 0.93

IL-2 production by virus- and tumor-specific human CD8 T cells is determined by their fine specificity. J Immunol (2004) 0.93

A comparison of imaging techniques to monitor tumor growth and cancer progression in living animals. Int J Mol Imaging (2011) 0.92

Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression. Am J Cancer Res (2011) 0.91

Differential expression of steroid 5alpha-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer. Endocr Relat Cancer (2010) 0.90

Role of PKC-delta on substance P-induced chemokine synthesis in pancreatic acinar cells. Am J Physiol Cell Physiol (2007) 0.90

Cross-presentation of human cytomegalovirus pp65 (UL83) to CD8+ T cells is regulated by virus-induced, soluble-mediator-dependent maturation of dendritic cells. J Virol (2002) 0.88

Reciprocal regulation of the survival and apoptosis of Th17 and Th1 cells in the colon. Inflamm Bowel Dis (2011) 0.88

Multiparameter precursor analysis of T-cell responses to antigen. J Immunol Methods (2003) 0.87

A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells. J Virol (2007) 0.87

Immune microenvironment in tumor progression: characteristics and challenges for therapy. J Oncol (2012) 0.87

Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1. J Immunol (2009) 0.87

IEX-1 deficiency protects against colonic cancer. Mol Cancer Res (2012) 0.87

Composition of MHC class II-enriched lipid microdomains is modified during maturation of primary dendritic cells. J Leukoc Biol (2003) 0.86

Histological features associated with occult lymph node metastasis in FIGO clinical stage I, grade I endometrioid carcinoma. Histopathology (2013) 0.85

HMG-I(Y) and the CBP/p300 coactivator are essential for human papillomavirus type 18 enhanceosome transcriptional activity. Mol Cell Biol (2003) 0.84

Immune predictors of cancer progression. Immunol Res (2012) 0.84

Aurora-A expression, hormone receptor status and clinical outcome in hormone related cancers. Pathology (2010) 0.83

Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes. Int J Cancer (2004) 0.82

Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands. Oncoimmunology (2013) 0.82

Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS One (2013) 0.81

Frequent alterations of the beta-catenin protein in cancer of the uterine cervix. Tumour Biol (2002) 0.81

The human papillomavirus E6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of TAp63β upon transformation. PLoS Pathog (2011) 0.81

HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han. Int J Dermatol (2004) 0.81

Paucilymphoid non-keratinizing nasopharyngeal carcinoma with prominent stromal desmoplasia--an unusual case reported with brief comments on uncommon histological variants. Int J Clin Exp Pathol (2011) 0.80

Human papillomavirus proteins as prospective therapeutic targets. Microb Pathog (2012) 0.80

Mutational analysis and molecular modeling of the binding of Staphylococcus aureus enterotoxin C2 to a murine T cell receptor Vbeta10 chain. Eur J Immunol (2002) 0.80

Targeted gene delivery to differentiated skeletal muscle: a tool to study dedifferentiation. Dev Dyn (2007) 0.80

Negative contrast Cerenkov luminescence imaging of blood vessels in a tumor mouse model using [68Ga]gallium chloride. EJNMMI Res (2014) 0.79

Endocervical involvement in endometrial adenocarcinoma is not prognostically significant and the pathologic assessment of the pattern of involvement is not reproducible. Gynecol Oncol (2012) 0.79

Photodynamic activity of plant extracts from Sarawak, Borneo. Chem Biodivers (2013) 0.78

HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation. Virology (2012) 0.78

Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA2 as a membrane-binding vector. FEBS Lett (2005) 0.77

Naive CD8+ T cell recruitment and proliferation are dependent on stage of dendritic cell maturation. Eur J Immunol (2003) 0.76

Myeloid cells: Prime drivers of tumor progression. Oncoimmunology (2012) 0.76

Selection of Mesenchymal-Like Metastatic Cells in Primary Tumors - An in silico Investigation. Front Immunol (2012) 0.76

Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Oncol Rep (2007) 0.76

Detection, enumeration, and characterization of immune cells infiltrating melanoma tumors. Methods Mol Biol (2013) 0.75

How to develop better screens for anti-cancer therapies? Oncoimmunology (2012) 0.75

Tumor-Immune interactions: implications for cancer therapy. Cell Cycle (2015) 0.75

[Clinical features and ETFDH mutations of children with late-onset glutaric aciduria type II: a report of two cases]. Zhongguo Dang Dai Er Ke Za Zhi (2017) 0.75

[Heritability of insulin sensitivity in twins]. Beijing Da Xue Xue Bao (2003) 0.75

Identification of a clinical-grade maturation factor for dendritic cells. J Immunother (2002) 0.75

In silico modeling of cancer cell dissemination and metastasis. Ann N Y Acad Sci (2013) 0.75