Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation.

PubWeight™: 0.87‹?›

🔗 View Article (PMC 3555419)

Published in Pulm Circ on October 01, 2012

Authors

David E Green1, Bum-Yong Kang, Tamara C Murphy, C Micheal Hart

Author Affiliations

1: Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA.

Articles citing this

Hypoxia mediates mutual repression between microRNA-27a and PPARγ in the pulmonary vasculature. PLoS One (2013) 0.97

PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21. PLoS One (2015) 0.81

Plasma Proteomic Study in Pulmonary Arterial Hypertension Associated with Congenital Heart Diseases. Sci Rep (2016) 0.78

MURC deficiency in smooth muscle attenuates pulmonary hypertension. Nat Commun (2016) 0.78

Role of Rho kinase and Na+/H+ exchange in hypoxia-induced pulmonary arterial smooth muscle cell proliferation and migration. Physiol Rep (2016) 0.77

Peroxisome Proliferator-Activated Receptor γ and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. Am J Respir Cell Mol Biol (2016) 0.77

TSP1-CD47 Signaling is Upregulated in Clinical Pulmonary Hypertension and Contributes to Pulmonary Arterial Vasculopathy and Dysfunction. Cardiovasc Res (2016) 0.77

Effects of chrysin (5,7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats. Chin Med (2015) 0.76

Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells. Am J Med Sci (2016) 0.75

Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung. Am J Respir Cell Mol Biol (2017) 0.75

PPARγ attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart. Pulm Circ (2017) 0.75

Thrombospondins: A Role in Cardiovascular Disease. Int J Mol Sci (2017) 0.75

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med (2007) 33.21

Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol (2009) 12.05

NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res (2000) 8.62

ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol (2009) 7.94

Pulmonary arterial hypertension. N Engl J Med (2004) 6.69

Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med (2006) 6.06

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal (2005) 4.74

Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2003) 4.56

Bone morphogenetic protein receptors and signal transduction. J Biochem (2009) 4.51

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest (1998) 4.00

Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95

Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69

Vascular NAD(P)H oxidases: specific features, expression, and regulation. Am J Physiol Regul Integr Comp Physiol (2003) 3.63

Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28

Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev (2000) 3.18

Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol (2000) 3.01

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation (2010) 2.85

NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol (2009) 2.83

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med (2008) 2.68

Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 2.62

Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation (2007) 2.60

The functions of thrombospondin-1 and-2. Curr Opin Cell Biol (2000) 2.56

The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta. J Biol Chem (1999) 2.43

TGF-beta signaling in vascular biology and dysfunction. Cell Res (2009) 2.25

Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox). Am J Physiol Lung Cell Mol Physiol (2005) 2.18

Novel homologs of gp91phox. Trends Biochem Sci (2000) 2.00

Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res (2003) 2.00

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J Cell Biol (1988) 1.94

Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model. Am J Respir Cell Mol Biol (2009) 1.88

Transforming growth factor-beta complexes with thrombospondin. Mol Biol Cell (1992) 1.74

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res (2012) 1.69

PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol (2010) 1.60

Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem (2001) 1.52

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3. Am J Physiol Lung Cell Mol Physiol (2008) 1.52

The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell (2010) 1.49

Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol (2008) 1.45

Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-beta. J Cell Biol (1990) 1.35

[Effects of peroxisome proliferator-activated receptor gamma ligands on monocrotaline-induced pulmonary hypertension in rats]. Nihon Kokyuki Gakkai Zasshi (2005) 1.29

Redox control of vascular smooth muscle proliferation. J Lab Clin Med (1998) 1.29

Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling. J Appl Physiol (1985) (2005) 1.25

Oxidative stress modulates PPAR gamma in vascular endothelial cells. Free Radic Biol Med (2010) 1.13

Beta3 integrins are upregulated after vascular injury and modulate thrombospondin- and thrombin-induced proliferation of cultured smooth muscle cells. Circulation (1998) 1.12

Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats. Respirology (2010) 1.12

Thrombospondin-1 is a potent mitogen and chemoattractant for human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (1997) 1.09

Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension. Respir Res (2005) 1.07

The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2011) 1.06

Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension. J Cardiothorac Surg (2010) 0.97

Hypoxia induces transforming growth factor-beta1 gene expression in the pulmonary artery of rats via hypoxia-inducible factor-1alpha. Acta Biochim Biophys Sin (Shanghai) (2007) 0.95

Autocrine thrombospondin partially mediates TGF-beta1- induced proliferation of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol (2000) 0.82

TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases. Curr Opin Pharmacol (2009) 0.81

Articles by these authors

PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol (2010) 1.60

The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Am J Respir Cell Mol Biol (2012) 1.34

Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance. Circ Cardiovasc Imaging (2010) 1.14

Oxidative stress modulates PPAR gamma in vascular endothelial cells. Free Radic Biol Med (2010) 1.13

Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res (2002) 1.11

The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol (2011) 1.06

Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK. J Biol Chem (2003) 1.05

Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2. J Cell Physiol (2006) 1.03

Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells. J Cell Biochem (2004) 0.98

Hypoxia downregulates PPARγ via an ERK1/2-NF-κB-Nox4-dependent mechanism in human pulmonary artery smooth muscle cells. Free Radic Biol Med (2013) 0.98

Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. PLoS One (2011) 0.97

Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Endocrinology (2003) 0.92

Is peroxisome proliferator-activated receptor gamma (PPARγ) a therapeutic target for the treatment of pulmonary hypertension? Pulm Circ (2011) 0.88

Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion. J Biol Chem (2003) 0.88

Deletion of LOX-1 attenuates renal injury following angiotensin II infusion. Kidney Int (2009) 0.88

Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase. J Biol Chem (2005) 0.87

PPARgamma as a potential therapeutic target in pulmonary hypertension. Ther Adv Respir Dis (2010) 0.87

AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol. Atherosclerosis (2010) 0.86

Statins and angiogenesis: is it about connections? Biochem Biophys Res Commun (2009) 0.85

The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells. Bone (2008) 0.85

IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo. Prostate (2006) 0.83

Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit. Int J Vasc Med (2011) 0.79

An AFLP-based linkage map of Japanese red pine (Pinus densiflora) using haploid DNA samples of megagametophytes from a single maternal tree. Mol Cells (2005) 0.75