Published in J Cell Sci on February 01, 2013
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Identification of domains required for developmentally regulated SNARE function in Saccharomyces cerevisiae. Genetics (2000) 1.61
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Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood (2008) 1.37
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Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol (2003) 1.28
v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Mol Cell Biol (1991) 1.26
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci (2010) 1.22
ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. Biochem Biophys Res Commun (2008) 1.22
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The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol (2007) 1.14
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood (2007) 1.13
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ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Mol Biol Cell (2003) 1.08
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Dissociation of recruitment and activation of the small G-protein Rac during Fcgamma receptor-mediated phagocytosis. J Biol Chem (2006) 0.99
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A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol (2010) 0.98
Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proc Natl Acad Sci U S A (2011) 0.98
Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization. J Biol Chem (2011) 0.96
Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA. Cell Signal (2011) 0.95
IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Lett (2010) 0.95
PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils. J Cell Sci (2011) 0.93
The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol (2011) 0.93
The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association. Cell Signal (2011) 0.93
Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton. Biochim Biophys Acta (2009) 0.93
The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal (2011) 0.91
Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases. Biochim Biophys Acta (2009) 0.90
Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis. Hum Reprod (2011) 0.90
Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity. J Biol Chem (2012) 0.88
Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. Cell Signal (2012) 0.85
PA binding of phosphatidylinositol 4-phosphate 5-kinase. Adv Enzyme Regul (2007) 0.84
Purification and biochemical properties of Rac1, 2, 3 and the splice variant Rac1b. Methods Enzymol (2006) 0.83
Identification of molecular switch regulating interactions of Janus kinase 3 with cytoskeletal proteins. J Biol Chem (2012) 0.83
Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth. J Biol Chem (2010) 0.82
Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins Other Lipid Mediat (2008) 0.81
A membrane-associated GDP/GTP exchange protein specific for Rho small GTP-binding protein - partial purification and characterization from rat brain. Oncogene (1996) 0.78
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood (2006) 1.44
Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J (2007) 1.36
Molecular crosstalk between p70S6k and MAPK cell signaling pathways. Biochem Biophys Res Commun (2002) 1.02
Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling. J Biol Chem (2010) 1.00
Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J Biol Chem (2011) 0.98
A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol (2010) 0.98
Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proc Natl Acad Sci U S A (2011) 0.98
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J Mol Biol (2007) 0.97
The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol (2010) 0.96
IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Lett (2010) 0.95
The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. Biochem Biophys Res Commun (2005) 0.94
Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem (2014) 0.94
The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association. Cell Signal (2011) 0.93
The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol (2011) 0.93
A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism. Mol Cell Biol (2011) 0.92
Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3). J Mol Biol (2011) 0.92
Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity. J Biol Chem (2012) 0.88
Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion. J Mol Biol (2012) 0.88
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal (2007) 0.86
Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function. J Biol Chem (2010) 0.85
Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. Cell Signal (2012) 0.85
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol (2009) 0.85
PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem Biophys Res Commun (2009) 0.84
Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem Biophys Res Commun (2007) 0.84
A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src. J Cell Sci (2015) 0.83
Phospholipase D (PLD) gene expression in human neutrophils and HL-60 differentiation. J Leukoc Biol (2005) 0.83
Cloning of PLD2 from baculovirus for studies in inflammatory responses. Methods Mol Biol (2012) 0.82
A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells. J Biol Chem (2013) 0.82
Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action. J Biol Chem (2011) 0.79
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells. BMC Microbiol (2013) 0.78
Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression. J Leukoc Biol (2013) 0.78
Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF. Small GTPases (2012) 0.77
Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF. Leuk Res (2005) 0.77