Published in Biochem Biophys Res Commun on June 24, 2005
The elucidation of novel SH2 binding sites on PLD2. Oncogene (2006) 1.15
New concepts in phospholipase D signaling in inflammation and cancer. ScientificWorldJournal (2010) 1.01
A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol (2010) 0.98
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J Mol Biol (2007) 0.97
The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol (2010) 0.96
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal (2011) 0.91
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal (2007) 0.86
Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem Biophys Res Commun (2007) 0.84
PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem Biophys Res Commun (2009) 0.84
Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells. Blood (2006) 0.83
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol (1994) 3.35
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol (1997) 3.22
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem (1995) 3.10
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem (2001) 2.65
Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem (2001) 2.60
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J (1997) 2.49
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem (2000) 2.32
Phospholipase D: molecular and cell biology of a novel gene family. Biochem J (2000) 2.27
Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Proc Natl Acad Sci U S A (2004) 2.15
Regulation of phospholipase D. Biochim Biophys Acta (1999) 1.76
Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). J Biol Chem (1996) 1.58
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. Biochem J (1997) 1.56
Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol Cell Biochem (1998) 1.55
Tyrosine dephosphorylation of glycogen synthase kinase-3 is involved in its extracellular signal-dependent inactivation. FEBS Lett (1996) 1.51
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem (1998) 1.46
Identification and characterization of a gene encoding phospholipase D activity in yeast. J Biol Chem (1996) 1.39
Structure and regulation of phospholipase D. Trends Pharmacol Sci (1996) 1.37
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene (1999) 1.29
PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation. J Biol Chem (1998) 1.18
Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain. J Biol Chem (1997) 1.18
Involvement of tyrosine phosphorylation and protein kinase C in the activation of phospholipase D by H2O2 in Swiss 3T3 fibroblasts. J Biol Chem (1998) 1.16
Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol (2003) 1.15
Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. Oncogene (1995) 1.11
Cloning and expression analysis of murine phospholipase D1. Biochem J (1997) 1.10
Rapamycin inhibits GM-CSF-induced neutrophil migration. FEBS Lett (2003) 1.10
Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. Oncogene (2004) 1.09
Association of the N- and C-terminal domains of phospholipase D. Contribution of the conserved HKD motifs to the interaction and the requirement of the association for Ser/Thr phosphorylation of the enzyme. J Biol Chem (2000) 1.08
Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. Biochemistry (2002) 1.08
Cloning and characterization of phospholipase D from rat brain. J Biol Chem (1997) 1.08
Characterization of human PLD2 and the analysis of PLD isoform splice variants. FASEB J (1998) 1.00
Human phospholipase D1 can be tyrosine-phosphorylated in HL-60 granulocytes. J Biol Chem (1997) 0.99
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. J Biol Chem (2002) 0.98
The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J Cell Biol (1991) 0.97
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol (2004) 0.95
Regulation of phospholipase D2 activity by protein kinase C alpha. J Biol Chem (2004) 0.94
Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification. Biochim Biophys Acta (2001) 0.91
Reconstitution of interactions between protein-tyrosine phosphatase CD45 and tyrosine-protein kinase p56(lck) in nonlymphoid cells. J Biol Chem (1997) 0.90
Cloning, differential regulation and tissue distribution of alternatively spliced isoforms of ADP-ribosylation-factor-dependent phospholipase D from rat liver. Biochem J (1998) 0.89
S6 kinase p90rsk in granulocyte-macrophage colony-stimulating factor-stimulated proliferative and mature hematopoietic cells. J Biol Chem (1996) 0.89
Regulation of phospholipase D by tyrosine kinases. Chem Phys Lipids (1996) 0.88
Role of phospholipase D activation in nervous system physiology and pathophysiology. J Neurochem (1995) 0.88
The regulation of antigen-receptor signaling by protein tyrosine phosphatases: a hole in the story. Curr Opin Immunol (1999) 0.86
Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. J Biol Chem (2001) 0.85
Measurements of phospholipases A2, C, and D (PLA2, PLC, and PLD). In vitro microassays, analysis of enzyme isoforms, and intact-cell assays. Methods Mol Biol (2003) 0.80
Immunoprecipitation of a phospholipase D activity with antiphosphotyrosine antibodies. J Interferon Cytokine Res (1995) 0.79
Activation of phospholipase D is not mediated by direct phosphorylation on tyrosine residues. Biochim Biophys Acta (2003) 0.77
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood (2006) 1.44
Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J (2007) 1.36
The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly. Mol Biol Cell (2006) 1.21
Molecular crosstalk between p70S6k and MAPK cell signaling pathways. Biochem Biophys Res Commun (2002) 1.02
Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling. J Biol Chem (2010) 1.00
Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J Biol Chem (2011) 0.98
A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol (2010) 0.98
Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proc Natl Acad Sci U S A (2011) 0.98
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J Mol Biol (2007) 0.97
The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts. Mol Cell Biol (2010) 0.96
IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3). FEBS Lett (2010) 0.95
Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem (2014) 0.94
The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol (2011) 0.93
The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association. Cell Signal (2011) 0.93
A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism. Mol Cell Biol (2011) 0.92
Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3). J Mol Biol (2011) 0.92
Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity. J Biol Chem (2012) 0.88
Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion. J Mol Biol (2012) 0.88
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner. Cell Signal (2007) 0.86
Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function. J Biol Chem (2010) 0.85
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation. Mol Cell Biol (2009) 0.85
Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras. Cell Signal (2012) 0.85
Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem Biophys Res Commun (2007) 0.84
PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem Biophys Res Commun (2009) 0.84
Phospholipase D (PLD) gene expression in human neutrophils and HL-60 differentiation. J Leukoc Biol (2005) 0.83
A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src. J Cell Sci (2015) 0.83
A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells. J Biol Chem (2013) 0.82
Tetracycline labeling as a measure of humeral head viability after 3- or 4-part proximal humerus fracture. J Shoulder Elbow Surg (2009) 0.80
Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action. J Biol Chem (2011) 0.79
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells. BMC Microbiol (2013) 0.78
Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expression. J Leukoc Biol (2013) 0.78
A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration. J Cell Sci (2013) 0.78
Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF. Small GTPases (2012) 0.77
Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF. Leuk Res (2005) 0.77