PubRank

Michael N Weedon

Author PubWeight™ 361.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007 37.88
2 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008 35.06
3 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007 32.97
4 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
5 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
6 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
7 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
8 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010 16.96
9 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
10 Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007 12.62
11 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010 12.27
12 Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003 8.19
13 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
14 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
15 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009 5.81
16 Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet 2012 5.55
17 Genomic inflation factors under polygenic inheritance. Eur J Hum Genet 2011 4.89
18 A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008 4.75
19 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008 4.57
20 Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 2007 3.84
21 Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 2006 3.79
22 Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes 2008 3.76
23 Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 2007 3.58
24 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010 3.37
25 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
26 Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach. Diabetes 2009 2.85
27 Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007 2.73
28 Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet 2009 2.58
29 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 2012 2.34
30 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011 2.21
31 A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet 2009 2.02
32 Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet 2011 1.83
33 Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013 1.72
34 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
35 Predicting human height by Victorian and genomic methods. Eur J Hum Genet 2009 1.69
36 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 2008 1.64
37 Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 2009 1.61
38 Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 2009 1.58
39 Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet 2007 1.52
40 A genome-wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet 2013 1.50
41 Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Diabetes 2008 1.33
42 Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance. Diabetes 2011 1.29
43 An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci 2007 1.27
44 Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 2003 1.24
45 A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab 2008 1.15
46 Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med 2006 1.15
47 Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab 2006 1.14
48 Next-generation sequencing reveals deep intronic cryptic ABCC8 and HADH splicing founder mutations causing hyperinsulinism by pseudoexon activation. Am J Hum Genet 2012 1.14
49 Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans. BMC Med Genet 2006 1.11
50 Adult height variants affect birth length and growth rate in children. Hum Mol Genet 2011 1.11
51 Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet 2010 1.10
52 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes 2013 1.06
53 Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One 2013 1.05
54 Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans. J Med Genet 2014 1.03
55 Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. J Clin Endocrinol Metab 2009 0.95
56 Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet 2011 0.94
57 Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects. Diabetes 2003 0.93
58 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2015 0.90
59 The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet 2006 0.89
60 The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a β cell phenotype. J Med Genet 2013 0.87
61 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes 2009 0.82
62 Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels. Eur J Hum Genet 2007 0.81
63 Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP 2006 0.80
64 Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. Diabetes 2006 0.79
65 Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity. Toxicol Appl Pharmacol 2002 0.79
66 A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia 2015 0.79
67 A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. J Negat Results Biomed 2006 0.76
68 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 2016 0.76
69 Tall stories: the fundamental difficulties of genetic association studies. Clin Endocrinol (Oxf) 2004 0.75