Published in Diabetes on June 30, 2008
Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med (2008) 9.68
The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nat Rev Endocrinol (2011) 5.55
Phenomics: the next challenge. Nat Rev Genet (2010) 4.20
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med (2009) 3.68
Decanalization and the origin of complex disease. Nat Rev Genet (2009) 3.12
From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes. PLoS Genet (2009) 2.99
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol (2009) 2.71
Genome-wide association studies in type 2 diabetes. Curr Diab Rep (2009) 2.60
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes (2009) 2.54
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ (2010) 2.53
Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet (2011) 2.48
Risk assessment tools for identifying individuals at risk of developing type 2 diabetes. Epidemiol Rev (2011) 2.01
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS One (2009) 1.86
Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) study. Diabetes (2010) 1.71
Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab (2008) 1.61
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proc Natl Acad Sci U S A (2010) 1.60
Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol (2009) 1.60
Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling. J Gen Intern Med (2011) 1.56
Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet (2010) 1.54
Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42,103 individuals. Gut (2012) 1.52
Perceived impact of diabetes genetic risk testing among patients at high phenotypic risk for type 2 diabetes. Diabetes Care (2011) 1.47
Genome-based prediction of common diseases: methodological considerations for future research. Genome Med (2009) 1.46
What is a functional locus? Understanding the genetic basis of complex phenotypic traits. Med Hypotheses (2011) 1.46
Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS One (2010) 1.43
Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose. Genet Epidemiol (2010) 1.34
Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care (2013) 1.34
Genomics of type 2 diabetes mellitus: implications for the clinician. Nat Rev Endocrinol (2009) 1.34
Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes. BMC Cancer (2010) 1.30
Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care (2009) 1.29
Improved risk prediction for Crohn's disease with a multi-locus approach. Hum Mol Genet (2011) 1.28
Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes (2008) 1.27
Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Diabetologia (2010) 1.27
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. PLoS Genet (2011) 1.27
Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. Hypertension (2010) 1.26
Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma. Thyroid (2013) 1.20
Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care (2012) 1.19
Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care (2012) 1.17
A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research. Curr Diab Rep (2011) 1.16
Missing heritability and GWAS utility. Obesity (Silver Spring) (2009) 1.15
Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Curr Genomics (2009) 1.14
Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus. PLoS One (2012) 1.13
Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review. Am J Epidemiol (2013) 1.11
Familial risks for type 2 diabetes in Sweden. Diabetes Care (2009) 1.10
Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. Hum Hered (2010) 1.10
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study. Hum Mol Genet (2010) 1.10
A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS). Diabetologia (2009) 1.08
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps. Diabetes (2009) 1.07
Being more realistic about the public health impact of genomic medicine. PLoS Med (2010) 1.06
Type 2 diabetes and obesity: genomics and the clinic. Hum Genet (2011) 1.04
Genetic risk profiling for prediction of type 2 diabetes. PLoS Curr (2011) 1.03
Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab Syndr Obes (2012) 1.01
Animal models of GWAS-identified type 2 diabetes genes. J Diabetes Res (2013) 1.01
Practical issues in building risk-predicting models for complex diseases. J Biopharm Stat (2010) 1.00
Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. Ann Behav Med (2010) 1.00
Combined effects of 17 common genetic variants on type 2 diabetes risk in a Han Chinese population. Diabetologia (2010) 1.00
Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population. PLoS One (2011) 1.00
SLC30A8 mutations in type 2 diabetes. Diabetologia (2014) 0.99
Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes (2009) 0.98
Genetics factors contributing to type 2 diabetes across ethnicities. J Diabetes Sci Technol (2009) 0.98
Annotating individual human genomes. Genomics (2011) 0.97
Determination of 14 circulating microRNAs in Swedes and Iraqis with and without diabetes mellitus type 2. PLoS One (2014) 0.95
Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiol Genomics (2010) 0.95
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Epidemiol (2011) 0.94
Translating genomics into improved population screening: hype or hope? Hum Genet (2011) 0.94
Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring. J Clin Invest (2014) 0.93
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility. Diabetologia (2010) 0.93
Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study. Aging (Albany NY) (2011) 0.91
Genomic risk models improve prediction of longitudinal lipid levels in children and young adults. Front Genet (2013) 0.89
Genetics of type 2 diabetes in European populations. J Diabetes (2012) 0.89
Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes. PLoS One (2013) 0.88
Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals. PLoS One (2012) 0.88
Body mass index, triglycerides, glucose, and blood pressure as predictors of type 2 diabetes in a middle-aged Norwegian cohort of men and women. Clin Epidemiol (2012) 0.88
Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study. BMC Proc (2009) 0.88
Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk. Mol Autism (2010) 0.88
The effect of multiple genetic variants in predicting the risk of type 2 diabetes. BMC Proc (2009) 0.87
Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W. Diabetol Metab Syndr (2010) 0.87
Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. J Hum Genet (2011) 0.87
Genomics of heart failure. Heart Fail Clin (2010) 0.87
Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation. Mol Biol Evol (2009) 0.87
Genetics of Type 2 Diabetes and Clinical Utility. Genes (Basel) (2015) 0.86
Identification of genetic loci involved in diabetes using a rat model of depression. Mamm Genome (2009) 0.86
Reading and language disorders: the importance of both quantity and quality. Genes (Basel) (2014) 0.86
Gene-gene and gene-environment interactions in the etiology of type 2 diabetes mellitus in the population of Hyderabad, India. Meta Gene (2015) 0.85
Impact of a Booklet about Diabetes Genetic Susceptibility and Its Prevention on Attitudes towards Prevention and Perceived Behavioral Change in Patients with Type 2 Diabetes and Their Offspring. Adv Prev Med (2010) 0.85
Population-based screening in the era of genomics. Per Med (2012) 0.84
A comparison of Bayesian and frequentist approaches to incorporating external information for the prediction of prostate cancer risk. Genet Epidemiol (2012) 0.84
Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes. PLoS One (2009) 0.83
Monogenic models: what have the single gene disorders taught us? Curr Diab Rep (2012) 0.83
Estimating the predictive ability of genetic risk models in simulated data based on published results from genome-wide association studies. Front Genet (2014) 0.83
An alternative to the search for single polymorphisms: toward molecular personality scales for the five-factor model. J Pers Soc Psychol (2010) 0.82
Translating associations between common kidney diseases and genetic variation into the clinic. Semin Nephrol (2010) 0.82
A multiclass likelihood ratio approach for genetic risk prediction allowing for phenotypic heterogeneity. Genet Epidemiol (2013) 0.82
Genetic susceptibility to type 2 diabetes and implications for therapy. J Diabetes Sci Technol (2009) 0.82
Clinical translation of genetic predictors for type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2009) 0.81
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice. PLoS One (2013) 0.81
Evaluating diagnostic accuracy of genetic profiles in affected offspring families. Stat Med (2010) 0.81
Public health genomics approach to type 2 diabetes. Diabetes (2008) 0.81
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Hum Genet (2011) 0.79
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med (2001) 56.11
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care (1997) 23.95
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet (2007) 19.18
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet (2006) 11.64
TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med (2006) 7.75
Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet (2007) 6.55
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest (2007) 5.02
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes (2007) 3.84
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med (2006) 3.75
Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet (2007) 3.58
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes (2007) 2.73
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes (2004) 2.52
The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med (2007) 2.34
Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Am J Hum Genet (2008) 2.20
The importance of TCF7L2. Diabet Med (2007) 1.28
Improved identification of patients with coronary artery disease by the use of new lipid and lipoprotein biomarkers. Am J Cardiol (2006) 1.02
Finding the missing heritability of complex diseases. Nature (2009) 67.95
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Metformin and reduced risk of cancer in diabetic patients. BMJ (2005) 13.04
Five years of GWAS discovery. Am J Hum Genet (2012) 12.97
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
An evaluation of statistical approaches to rare variant analysis in genetic association studies. Genet Epidemiol (2010) 10.54
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med (2004) 8.62
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94