Targeting the HGF/c-MET pathway in hepatocellular carcinoma.

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Published in Clin Cancer Res on February 06, 2013

Authors

Lipika Goyal1, Mandar D Muzumdar, Andrew X Zhu

Author Affiliations

1: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature (1987) 6.26

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Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature (1984) 5.85

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Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun (1984) 3.70

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Serum hepatocyte growth factor levels in liver diseases: clinical implications. Hepatology (1995) 1.08

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Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine. Jpn J Cancer Res (1995) 0.80

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