Epithelial-mesenchymal transition: a new target in anticancer drug discovery.

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Published in Nat Rev Drug Discov on January 29, 2016

Authors

Fabrizio Marcucci1, Giorgio Stassi2, Ruggero De Maria3

Author Affiliations

1: Scientific Directorate, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy. Present address: Department of Pharmacological and Biomolecular Sciences, University of Milan, via Trentacoste 2, 20133 Milan, Italy.
2: Department of Surgical and Oncological Sciences, University of Palermo, Via del Vespro 131, 90127 Palermo, Italy.
3: Scientific Directorate, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy.

Associated clinical trials:

A Study of Gemcitabine and Demcizumab (OMP-21M18) With or Without Abraxane® as 1st-line Treatment in Subjects With Locally Advanced or Metastatic Pancreatic Cancer | NCT01189929

A Study of Carboplatin and Pemetrexed Plus Demcizumab (OMP-21M18) in Subjects With Non-Squamous Non-Small Cell Lung Cancer | NCT01189968

A Phase 1 Dose Escalation Study of OMP-21M18 in Subjects With Solid Tumors | NCT00744562

A Study of FOLFIRI Plus OMP-21M18 as 1st or 2nd-line Treatment in Subjects With Metastatic Colorectal Cancer | NCT01189942

A Phase 1b/2 Study of OMP-59R5 in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer (ALPINE) | NCT01647828

A Dose Escalation Study of OMP-18R5 in Subjects With Solid Tumors | NCT01345201

A Dose Escalation Study of OMP-59R5 in Subjects With Solid Tumors | NCT01277146

Phase II Study of VS-6063 in Patients With KRAS Mutant Non-Small Cell Lung Cancer | NCT01951690

Phase I/Ib Study of Paclitaxel in Combination With VS-6063 in Patients With Advanced Ovarian Cancer | NCT01778803

Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma (COMMAND) | NCT01870609

A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer | NCT02005315

A Study of Vantictumab (OMP-18R5) in Combination With Docetaxel in Patients With Previously Treated NSCLC | NCT01957007

A Phase 1b/2 Study of OMP-59R5 in Combination With Etoposide and Platinum Therapy in Subjects With Untreated Extensive Stage Small Cell Lung Cancer (PINNACLE) (PINNACLE) | NCT01859741

A Study of Vantictumab (OMP-18R5) in Combination With Paclitaxel in Locally Recurrent or Metastatic Breast Cancer | NCT01973309

Window of Opportunity Study of VS-6063 (Defactinib) in Participants With Surgical Resectable Malignant Pleural Mesothelioma. | NCT02004028

Phase I Dose Escalation Study of VS-5584 in Subjects With Advanced Non-Hematologic Malignancies or Lymphoma | NCT01991938

A Study of Demcizumab Plus Paclitaxel in Subjects With Platinum Resistant Ovarian (SIERRA) | NCT01952249

A Study of BBI608 Administered in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Cancers | NCT02467361

Phase I Dose Escalation Study of VS-6063 in Japanese Subjects With Non-Hematologic Malignancies | NCT01943292

Study of Gemcitabine, Abraxane® Plus Placebo Versus Gemcitabine, Abraxane® Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With 1st-Line Metastatic Pancreatic Ductal Adenocarcinoma (YOSEMITE) | NCT02289898

A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer | NCT02231723

A Study of BBI608 Plus Weekly Paclitaxel to Treat Gastric and Gastro-Esophageal Junction Cancer (BRIGHTER) | NCT02178956

A Study of BGB324 in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer | NCT02424617

Multicenter Open-label Study of BGB324 as a Single Agent and in Combination With Cytarabine in Patients With AML | NCT02488408

A Study of Carboplatin, Pemetrexed Plus Placebo vs Carboplatin, Pemetrexed Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With Non-Squamous Non-Small Cell Lung Cancer (DENALI) | NCT02259582

Targeting the Hippo Transducer TAZ in Breast Cancer With Statins (TRINACRIA) | NCT02416427

A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer | NCT02024607

A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer | NCT01776307

Pre-operative Zoledronate in Triple Negative Breast Cancer | NCT02347163

A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma | NCT02315534

A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies | NCT02352558

A Study of BBI608 in Combination With Sorafenib, or BBI503 in Combination With Sorafenib in Adult Patients With Hepatocellular Carcinoma | NCT02279719

A Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies | NCT01325441

A Phase 1 Dose Escalation Study of VS-5584 Administered in Combination With VS-6063, in Subjects With Relapsed Malignant Mesothelioma | NCT02372227

BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Patients With Pretreated Advanced Colorectal Carcinoma | NCT01830621

A Study of BBI608 Administrated With Sorafenib in Adult Patients With Advanced Hepatocellular Carcinoma | NCT02358395

A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma | NCT02347917

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