Published in Integr Biol (Camb) on March 01, 2013
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomater (2014) 0.84
The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus. Front Immunol (2015) 0.81
Improving the design of the agarose spot assay for eukaryotic cell chemotaxis. RSC Adv (2014) 0.78
Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion. J Theor Biol (2017) 0.75
A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4. J Immunol (2017) 0.75
Analytical Prediction of the Spatiotemporal Distribution of Chemoattractants around Their Source: Theory and Application to Complement-Mediated Chemotaxis. Front Immunol (2017) 0.75
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell (1999) 12.50
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science (2002) 8.94
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Homing and cellular traffic in lymph nodes. Nat Rev Immunol (2003) 7.23
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity (2006) 7.22
Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med (1999) 6.09
Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol (2002) 5.37
Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annu Rev Cell Biol (1988) 5.30
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature (2006) 5.19
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu Rev Immunol (2005) 5.10
In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science (2008) 5.09
Reaction-diffusion model as a framework for understanding biological pattern formation. Science (2010) 4.72
Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol (2005) 4.59
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol (2005) 4.26
Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci U S A (2003) 4.22
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A (2003) 3.77
Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat Immunol (2007) 3.41
Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur J Immunol (1999) 3.04
Interstitial leukocyte migration and immune function. Nat Immunol (2008) 2.99
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med (2007) 2.81
Dynamics of neutrophil migration in lymph nodes during infection. Immunity (2008) 2.70
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol (2002) 2.55
Mechanisms of sensing chemical gradients by polymorphonuclear leukocytes. Nature (1974) 2.48
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell (2007) 2.48
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem (2004) 2.31
Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol (2003) 2.24
Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity (2010) 2.18
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur J Immunol (1998) 2.15
Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity (2010) 2.00
CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J Immunol (2007) 1.91
The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev (2003) 1.79
Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity (2009) 1.71
Moving targets: cell migration inhibitors as new anti-inflammatory therapies. Nat Immunol (2008) 1.68
Quantitative analysis of the 51Cr release cytotoxicity assay for cytotoxic lymphocytes. Cell Immunol (1974) 1.68
Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. J Biol Chem (2001) 1.57
Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proc Natl Acad Sci U S A (1997) 1.55
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess. Proc Natl Acad Sci U S A (2007) 1.54
Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol (2006) 1.53
A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol Rev (2003) 1.51
Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J Immunol (2000) 1.45
Homeostatic lymphoid chemokines synergize with adhesion ligands to trigger T and B lymphocyte chemokinesis. J Immunol (2006) 1.44
Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. Cancer Res (2009) 1.41
T cell chemotaxis in a simple microfluidic device. Lab Chip (2006) 1.40
Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol (2006) 1.37
Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19. Proc Natl Acad Sci U S A (2011) 1.36
Consequences of chemotactic peptide receptor modulation for leukocyte orientation. J Cell Biol (1981) 1.32
Cytokine-stimulated chemotaxis of human neutrophils in a 3-D conjoined fibrin gel assay. J Immunol Methods (1995) 1.32
Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest (2003) 1.27
Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4. J Immunol (2010) 1.25
Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation. J Immunol (2006) 1.25
Chemokines have diverse abilities to form solid phase gradients. Clin Immunol (2001) 1.22
Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. J Immunol (2008) 1.22
The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur J Immunol (2001) 1.22
Chemokines in host-parasite interactions in leishmaniasis. Trends Parasitol (2005) 1.18
Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation. Immunol Cell Biol (2005) 1.16
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J Exp Med (2005) 1.15
Autologous morphogen gradients by subtle interstitial flow and matrix interactions. Biophys J (2006) 1.13
Microfluidic technologies for temporal perturbations of chemotaxis. Annu Rev Biomed Eng (2010) 1.12
Directed cell migration via chemoattractants released from degradable microspheres. Biomaterials (2005) 1.11
Numerical simulations of angiogenesis in the cornea. Microvasc Res (2001) 1.10
Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood (2007) 1.09
EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC. Int Immunol (1998) 1.05
Controlled architectural and chemotactic studies of 3D cell migration. Biomaterials (2011) 0.97
Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres. Biomaterials (2011) 0.97
Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model. PLoS One (2010) 0.92
Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo. Adv Mater (2012) 0.91
Low-molecular-weight heparins inhibit CCL21-induced T cell adhesion and migration. J Pharmacol Exp Ther (2002) 0.91
Modeling the role of homologous receptor desensitization in cell gradient sensing. J Immunol (2008) 0.90
The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19. Biochem Biophys Res Commun (2006) 0.86
Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine? Allergy (2004) 0.83
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat Mater (2008) 4.81
T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol (2004) 3.85
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol (2004) 3.21
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater (2011) 2.71
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci (2002) 2.42
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proc Natl Acad Sci U S A (2011) 2.37
Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov (2011) 2.32
T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity (2011) 2.00
Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction. Proc Natl Acad Sci U S A (2012) 1.84
A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature (2004) 1.77
Engineering nano- and microparticles to tune immunity. Adv Mater (2012) 1.75
Layer-by-layer-assembled multilayer films for transcutaneous drug and vaccine delivery. ACS Nano (2009) 1.75
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles. Biomaterials (2012) 1.72
A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods (2010) 1.71
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat Med (2010) 1.71
Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles. Nano Lett (2007) 1.63
Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells. Proc Natl Acad Sci U S A (2006) 1.56
Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem (2003) 1.46
Homeostatic lymphoid chemokines synergize with adhesion ligands to trigger T and B lymphocyte chemokinesis. J Immunol (2006) 1.44
In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles. Proc Natl Acad Sci U S A (2011) 1.38
Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater (2013) 1.38
Interleukin-7 receptor signaling network: an integrated systems perspective. Cell Mol Immunol (2008) 1.22
In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles. Mol Pharm (2011) 1.17
Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol (2011) 1.14
Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A (2002) 1.13
Surface functionalization of living cells with multilayer patches. Nano Lett (2008) 1.13
Particulate vaccines: on the quest for optimal delivery and immune response. Drug Discov Today (2011) 1.10
Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA. Adv Mater (2010) 1.09
Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Sci Transl Med (2013) 1.09
Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b. J Virol (2013) 1.08
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med (2009) 1.08
Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Mol Ther (2005) 1.07
Drug delivery: One nanoparticle, one kill. Nat Mater (2011) 1.06
Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release (2011) 1.05
Localized immunotherapy via liposome-anchored Anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic antitumor immunity. Cancer Res (2013) 1.04
Membrane anchored immunostimulatory oligonucleotides for in vivo cell modification and localized immunotherapy. Angew Chem Int Ed Engl (2011) 1.04
Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist for multicomponent protein patterning. J Am Chem Soc (2004) 1.04
Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants. J Clin Invest (2015) 1.03
Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy. Biomaterials (2011) 1.02
Injectable dendritic cell-carrying alginate gels for immunization and immunotherapy. Biomaterials (2008) 1.02
Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers. Nano Lett (2013) 1.01
In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling. Biophys J (2011) 0.99
Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration. J Biomed Mater Res A (2008) 0.99
Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles. Biomacromolecules (2009) 0.98
Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine. PLoS One (2012) 0.98
Polymer-supported lipid shells, onions, and flowers. Soft Matter (2008) 0.98
Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres. Biomaterials (2011) 0.97
Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol (2010) 0.96
Enhancing Cell therapies from the Outside In: Cell Surface Engineering Using Synthetic Nanomaterials. Nano Today (2011) 0.96
Freely suspended cellular "backpacks" lead to cell aggregate self-assembly. Biomacromolecules (2010) 0.95
Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery. ACS Nano (2012) 0.93
Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors. Acta Biomater (2008) 0.92
Rapid conformational epitope mapping of anti-gp120 antibodies with a designed mutant panel displayed on yeast. J Mol Biol (2012) 0.91
Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination. Adv Funct Mater (2013) 0.91
Vaccine delivery with microneedle skin patches in nonhuman primates. Nat Biotechnol (2013) 0.89
Synthesis of protein-loaded hydrogel particles in an aqueous two-phase system for coincident antigen and CpG oligonucleotide delivery to antigen-presenting cells. Biomacromolecules (2005) 0.89
Large area two-dimensional B cell arrays for sensing and cell-sorting applications. Biomacromolecules (2004) 0.88
Beyond antigens and adjuvants: formulating future vaccines. J Clin Invest (2016) 0.87
Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy. Biomaterials (2009) 0.86
Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving. Anal Chem (2012) 0.83
Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes. ACS Nano (2014) 0.82
In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes. J Control Release (2013) 0.82
Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes. Nanoscale (2015) 0.82
Composition-tunable properties of amphiphilic comb copolymers containing protected methacrylic acid groups for multicomponent protein patterning. Langmuir (2006) 0.81
Design of lipid nanocapsule delivery vehicles for multivalent display of recombinant Env trimers in HIV vaccination. Bioconjug Chem (2014) 0.79
Creating patterned carbon nanotube catalysts through the microcontact printing of block copolymer micellar thin films. Langmuir (2006) 0.79
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest (2016) 0.79
Antigen delivery by lipid-enveloped PLGA microparticle vaccines mediated by in situ vesicle shedding. Biomacromolecules (2014) 0.78
Wound Healing Versus Regeneration: Role of the Tissue Environment in Regenerative Medicine. MRS Bull (2010) 0.78
Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules (2013) 0.77
Block copolymer micelles as nanocontainers for controlled release of proteins from biocompatible oil phases. Biomacromolecules (2009) 0.77
Nanoscience and Nanotechnology Cross Borders. ACS Nano (2017) 0.75
Erratum: High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry. Nat Commun (2017) 0.75