Published in Nat Immunol on July 11, 2004
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol (2008) 4.52
Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature (2010) 3.40
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J Exp Med (2010) 2.20
Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics. Proc Natl Acad Sci U S A (2005) 1.87
Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nat Immunol (2005) 1.85
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Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A (2006) 1.58
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity (2007) 1.52
Emergent dynamics of thymocyte development and lineage determination. PLoS Comput Biol (2006) 1.49
Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function. Proc Natl Acad Sci U S A (2005) 1.46
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Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci U S A (2007) 1.43
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Strength of PD-1 signaling differentially affects T-cell effector functions. Proc Natl Acad Sci U S A (2013) 1.42
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Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response. Biophys J (2006) 1.36
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery. Proc Natl Acad Sci U S A (2010) 1.28
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Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection. J Virol (2011) 1.17
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Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. J Immunol (2008) 1.12
A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol (2009) 1.11
Low ligand requirement for deletion and lack of synapses in positive selection enforce the gauntlet of thymic T cell maturation. Immunity (2008) 1.11
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T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med (2007) 1.06
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Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production. Mol Immunol (2007) 0.92
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Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun (2016) 0.91
Complexity and modularity of intracellular networks: a systematic approach for modelling and simulation. IET Syst Biol (2008) 0.90
SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation. J Biol Chem (2009) 0.90
A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn. J Immunol (2012) 0.89
Induction and stability of the anergic phenotype in T cells. Semin Immunol (2013) 0.87
Structural and biophysical insights into the role of CD4 and CD8 in T cell activation. Front Immunol (2013) 0.87
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The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla. J Immunol (2009) 0.84
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The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway. Sci Signal (2015) 0.83
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Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4(+) T Cell Proliferation. Am J Respir Cell Mol Biol (2017) 0.83
Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J Exp Med (2013) 0.83
T-cell activation: A queuing theory analysis at low agonist density. Biophys J (2006) 0.82
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Regulated movement of CD4 in and out of the immunological synapse. J Immunol (2008) 0.81
Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8. J Immunol (2011) 0.80
Computational investigations into the origins of short-term biochemical memory in T cell activation. PLoS One (2007) 0.80
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol (2014) 0.80
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Tubulin and actin interplay at the T cell and antigen-presenting cell interface. Front Immunol (2011) 0.80
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Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors. Trends Pharmacol Sci (2015) 0.79
Self help for T cells. Nat Immunol (2004) 0.79
Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef. Future Virol (2012) 0.78
Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A (2007) 0.77
A CB2-Selective Cannabinoid Suppresses T-Cell Activities and Increases Tregs and IL-10. J Neuroimmune Pharmacol (2015) 0.76
Adaptive immunity: Based on the dual recognition responses of αβT cells. Self Nonself (2010) 0.75
Recent advances in T-cell engineering for use in immunotherapy. F1000Res (2016) 0.75
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions. Proc Natl Acad Sci U S A (2016) 0.75
Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. J Immunol (2016) 0.75
Cellular level models as tools for cytokine design. Biotechnol Prog (2010) 0.75
Phosphorylation of a Tyrosine Residue on Zap70 by Lck and Its Subsequent Binding via an SH2 Domain May Be a Key Gatekeeper of T Cell Receptor Signaling In Vivo. Mol Cell Biol (2016) 0.75
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics (2016) 0.75
miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell (2007) 9.08
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Advances in methods and algorithms in a modern quantum chemistry program package. Phys Chem Chem Phys (2006) 6.51
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell (2006) 5.39
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity (2012) 5.26
Direct observation of ligand recognition by T cells. Nature (2002) 5.21
The immunological synapse balances T cell receptor signaling and degradation. Science (2003) 4.94
Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. Nat Mater (2008) 4.81
Cell type-specific gene expression differences in complex tissues. Nat Methods (2010) 4.75
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol (2008) 4.52
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nat Immunol (2009) 4.22
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature (2013) 3.90
Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol (2003) 3.88
T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol (2004) 3.85
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature (2005) 3.55
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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature (2010) 3.40
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Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity (2013) 3.38
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Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device. Proc Natl Acad Sci U S A (2009) 3.19
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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation. Mol Cell (2003) 2.61
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Directed migration of positively selected thymocytes visualized in real time. PLoS Biol (2005) 2.46
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A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol (2004) 2.20
The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity (2008) 2.13
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity (2007) 2.11
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