Published in Chem Biol on February 21, 2013
Activation of p38/JNK pathway is responsible for embelin induced apoptosis in lung cancer cells: transitional role of reactive oxygen species. PLoS One (2014) 0.86
Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. ACS Chem Biol (2015) 0.81
Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1. J Biol Chem (2015) 0.78
Serpin latency transition at atomic resolution. Proc Natl Acad Sci U S A (2014) 0.78
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy. Oncotarget (2016) 0.78
A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell Mol Med (2016) 0.75
Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1. Sci Rep (2016) 0.75
Histone Acetyltransferase PCAF is Required for All-trans Retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem (2017) 0.75
Embelin binds to human neuroserpin and impairs its polymerisation. Sci Rep (2016) 0.75
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Duplication and DNA segmental loss in the rice genome: implications for diploidization. New Phytol (2005) 3.65
Sexually transmitted disease prevalence and characteristics of market vendors in eastern China. Sex Transm Dis (2003) 2.02
Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure (2008) 1.93
Statistical inference of chromosomal homology based on gene colinearity and applications to Arabidopsis and rice. BMC Bioinformatics (2006) 1.91
Structure of human urokinase plasminogen activator in complex with its receptor. Science (2006) 1.84
Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol (2010) 1.71
Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes. Cardiovasc Res (2011) 1.64
Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood (2012) 1.26
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol (2008) 1.23
Carbon nanotubes as molecular transporters for walled plant cells. Nano Lett (2009) 1.22
Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells. Analyst (2009) 1.22
Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc (2011) 1.20
Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion. Am J Pathol (2009) 1.15
Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J Biol Chem (2010) 1.14
Plasminogen activator inhibitor-I and tumour growth, invasion, and metastasis. Thromb Haemost (2004) 1.11
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J Neurosci (2013) 1.10
Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin. J Struct Biol (2006) 1.07
Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics. Chem Biol (2004) 1.05
The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas. Am J Pathol (2003) 1.05
Evidence for a pre-latent form of the serpin plasminogen activator inhibitor-1 with a detached beta-strand 1C. J Biol Chem (2006) 1.04
Crystal structure of the urokinase receptor in a ligand-free form. J Mol Biol (2012) 1.03
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry (2005) 1.02
Cantilever sensor for nanomechanical detection of specific protein conformations. Nano Lett (2005) 1.02
An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. three-step synthesis of leucomelone. Org Lett (2009) 1.00
Amine-functionalized lanthanide-doped zirconia nanoparticles: optical spectroscopy, time-resolved fluorescence resonance energy transfer biodetection, and targeted imaging. J Am Chem Soc (2012) 0.99
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS J (2006) 0.98
A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. J Struct Biol (2007) 0.98
Activation of Arabidopsis seed hair development by cotton fiber-related genes. PLoS One (2011) 0.98
Copper ion-sensing transcription factor Mac1p post-translationally controls the degradation of its target gene product Ctr1p. J Biol Chem (2002) 0.97
Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol (2010) 0.97
Amine-functionalized lanthanide-doped KGdF4 nanocrystals as potential optical/magnetic multimodal bioprobes. J Am Chem Soc (2011) 0.97
The vitronectin binding area of plasminogen activator inhibitor-1, mapped by mutagenesis and protection against an inactivating organochemical ligand. FEBS Lett (2002) 0.96
Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem (2011) 0.96
Bio-distribution and metabolic paths of silica coated CdSeS quantum dots. Toxicol Appl Pharmacol (2008) 0.96
Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII. J Mol Biol (2007) 0.96
Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor. J Biol Chem (2011) 0.94
Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci (2008) 0.94
Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem (2010) 0.94
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents (2008) 0.94
Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells. Neoplasia (2011) 0.93
Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One (2011) 0.93
Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells. J Phys Chem B (2007) 0.93
Instantaneous preference was a stronger instrumental variable than 3- and 6-month prescribing preference for NSAIDs. J Clin Epidemiol (2008) 0.92
Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol (2005) 0.91
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem (2010) 0.91
A novel mode of intervention with serine protease activity: targeting zymogen activation. J Biol Chem (2008) 0.91
Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1. Biochem J (2003) 0.91
Contributions of meteorology to the phenology of cyanobacterial blooms: implications for future climate change. Water Res (2011) 0.91
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase. Exp Cell Res (2013) 0.91
Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1. Am J Clin Pathol (2004) 0.90
An anti-urokinase plasminogen activator receptor (uPAR) antibody: crystal structure and binding epitope. J Mol Biol (2006) 0.90
RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1. Biochemistry (2010) 0.90
Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain. J Biol Chem (2008) 0.89
Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori. FEBS Lett (2006) 0.89
Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy. Nanoscale (2014) 0.88
Structural mechanism of ring-opening reaction of glucose by human serum albumin. J Biol Chem (2013) 0.88
Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode. J Mol Biol (2011) 0.88
Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1. J Struct Biol (2007) 0.88
Structural basis of transport of lysophospholipids by human serum albumin. Biochem J (2009) 0.87
Mutational analysis of plasminogen activator inhibitor-1. Eur J Biochem (2003) 0.87
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. FEBS Lett (2004) 0.87
Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochem Pharmacol (2012) 0.87
Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Biochemistry (2007) 0.87
Quantification of microcystin-producing and non-microcystin producing Microcystis populations during the 2009 and 2010 blooms in Lake Taihu using quantitative real-time PCR. J Environ Sci (China) (2012) 0.87
Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells. Eur J Pharmacol (2012) 0.87
Vitronectin in human breast carcinomas. Biochim Biophys Acta (2003) 0.87
A urokinase-type plasminogen activator-inhibiting cyclic peptide with an unusual P2 residue and an extended protease binding surface demonstrates new modalities for enzyme inhibition. J Biol Chem (2005) 0.87
Lanthanide-doped LiLuF(4) upconversion nanoprobes for the detection of disease biomarkers. Angew Chem Int Ed Engl (2014) 0.87
Additivity in effects of vitronectin and monoclonal antibodies against alpha-helix F of plasminogen activator inhibitor-1 on its reactions with target proteinases. J Biol Chem (2004) 0.87
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome. J Biol Chem (2007) 0.86
Sub-10 nm lanthanide-doped CaF2 nanoprobes for time-resolved luminescent biodetection. Angew Chem Int Ed Engl (2013) 0.86
Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin. Biochemistry (2012) 0.86
Dissecting the effect of RNA aptamer binding on the dynamics of plasminogen activator inhibitor 1 using hydrogen/deuterium exchange mass spectrometry. ACS Chem Biol (2013) 0.86
The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation. Biochem J (2003) 0.86
Structural evidence of perfluorooctane sulfonate transport by human serum albumin. Chem Res Toxicol (2012) 0.86
Genetic polymorphism of GSTP1 and ERCC1 correlated with response to platinum-based chemotherapy in non-small cell lung cancer. Med Oncol (2014) 0.86
Small molecules from natural sources, targeting signaling pathways in diabetes. Biochim Biophys Acta (2010) 0.86
Biochemical importance of glycosylation of plasminogen activator inhibitor-1. Thromb Haemost (2003) 0.86
PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2. Thromb Haemost (2015) 0.86
BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles. Cancer Biol Ther (2007) 0.86