PubRank

Jane R Hanrahan

Author PubWeight™ 30.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorg Med Chem 2009 1.07
2 Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. Br J Pharmacol 2011 1.07
3 GABA(C) receptors as drug targets. Curr Drug Targets CNS Neurol Disord 2003 1.05
4 Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. J Pharmacol Exp Ther 2008 1.02
5 Modulation of ionotropic GABA receptors by natural products of plant origin. Adv Pharmacol 2006 1.00
6 A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chem Biol Drug Des 2008 0.95
7 Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology 2008 0.90
8 Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem 2008 0.88
9 Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review. Amino Acids 2013 0.87
10 Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine. J Ethnopharmacol 2009 0.86
11 Guanidino acids act as rho1 GABA(C) receptor antagonists. Neurochem Res 2009 0.86
12 Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochem Pharmacol 2012 0.86
13 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochem Pharmacol 2011 0.86
14 Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorg Med Chem Lett 2012 0.85
15 (3-Aminocyclopentyl)methylphosphinic acids: novel GABA(C) receptor antagonists. Neuropharmacology 2006 0.84
16 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. Eur J Pharmacol 2005 0.83
17 Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses. Neuropharmacology 2004 0.83
18 γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. J Neurochem 2010 0.83
19 Factors influencing pharmacy services in opioid substitution treatment. Drug Alcohol Rev 2013 0.82
20 Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors. Br J Pharmacol 2012 0.82
21 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol 2012 0.82
22 Medicinal chemistry of ρ GABAC receptors. Future Med Chem 2011 0.82
23 Differentiating enantioselective actions of GABOB: a possible role for threonine 244 in the binding site of GABA(C) ρ(1) receptors. ACS Chem Neurosci 2012 0.81
24 The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochem Res 2009 0.81
25 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists. J Med Chem 2009 0.80
26 Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia. Curr Med Chem 2015 0.80
27 Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res 2010 0.80
28 Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs. J Ethnopharmacol 2013 0.80
29 Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol 2004 0.79
30 Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain. J Neuroimmune Pharmacol 2015 0.78
31 Structurally diverse GABA antagonists interact differently with open and closed conformational states of the ρ1 receptor. ACS Chem Neurosci 2012 0.78
32 Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: application to four-step synthesis of gabazine (SR-95531). Org Biomol Chem 2010 0.77
33 Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates. J Med Chem 2013 0.76
34 Identification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA(A) receptors. ChemMedChem 2011 0.76
35 Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues. J Phys Chem A 2005 0.75
36 Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochem Res 2013 0.75
37 Studies on pyridazine azide cyclisation reactions. Org Biomol Chem 2004 0.75
38 Fitness to practise in pharmacy: a study of impairment in professional practice. Int J Clin Pharm 2012 0.75
39 Experimental and theoretical charge distribution in (Z)-N-methyl-C-phenylnitrone. Org Biomol Chem 2003 0.75
40 Experimental and theoretical charge density distribution in a host-guest system: synthetic terephthaloyl receptor complexed to adipic acid. J Phys Chem A 2012 0.75