Published in Chem Commun (Camb) on March 12, 2013
Investigating the selectivity of metalloenzyme inhibitors. J Med Chem (2013) 0.99
Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity. Biochemistry (2014) 0.81
Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin. Endocrinology (2014) 0.81
A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2014) 0.78
Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis. Pharmacol Res (2016) 0.76
Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors. J Am Chem Soc (2013) 0.75
Efficacy and cytotoxicity in cell culture of novel α-hydroxytropolone inhibitors of Hepatitis B virus ribonuclease H. Antiviral Res (2017) 0.75
Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol (2007) 4.83
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Chelator fragment libraries for targeting metalloproteinases. ChemMedChem (2010) 1.02
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Novel inhibitors of the Pseudomonas aeruginosa virulence factor LasB: a potential therapeutic approach for the attenuation of virulence mechanisms in pseudomonal infection. Antimicrob Agents Chemother (2011) 0.96
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Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med (2011) 10.03
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Revised nomenclature for avian telencephalon and some related brainstem nuclei. J Comp Neurol (2004) 3.69
Avian brains and a new understanding of vertebrate brain evolution. Nat Rev Neurosci (2005) 3.29
Paralysis after transforaminal epidural injection and previous spinal surgery. Reg Anesth Pain Med (2004) 3.06
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science (2002) 2.51
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
Herpes zoster (shingles) and postherpetic neuralgia. Mayo Clin Proc (2009) 2.35
Clinical practice guideline: hoarseness (dysphonia). Otolaryngol Head Neck Surg (2009) 2.31
Infection control by antibody disruption of bacterial quorum sensing signaling. Chem Biol (2007) 2.24
Evidence for ozone formation in human atherosclerotic arteries. Science (2003) 2.22
Brilliant Sm, Eu, Tb, and Dy chiral lanthanide complexes with strong circularly polarized luminescence. J Am Chem Soc (2007) 2.14
Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A (2004) 2.05
The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology (2013) 2.02
Computational inference of neural information flow networks. PLoS Comput Biol (2006) 1.95
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. Science (2008) 1.93
Postsynthetic modification of metal-organic frameworks. Chem Soc Rev (2009) 1.93
Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm(3+), Eu(3+), Tb(3+), Dy(3+). J Am Chem Soc (2003) 1.91
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A (2007) 1.85
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol (2009) 1.84
Identification of a potent botulinum neurotoxin a protease inhibitor using in situ lead identification chemistry. Org Lett (2006) 1.81
The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison. Angew Chem Int Ed Engl (2008) 1.80
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. Science (2008) 1.79
Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors. J Comb Chem (2006) 1.79
Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility. Chem Biol (2007) 1.78
A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns (2007) 1.77
Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns. J Comp Neurol (2013) 1.76
Treating cocaine addiction with viruses. Proc Natl Acad Sci U S A (2004) 1.75
Radiofrequency neurotomy for low back pain: evidence-based procedural guidelines. Pain Med (2005) 1.56
Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species. Angew Chem Int Ed Engl (2012) 1.55
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int (2010) 1.54
Allergic reactions during anesthesia at a large United States referral center. Anesth Analg (2011) 1.54
Genes that confer the identity of the renin cell. J Am Soc Nephrol (2011) 1.52
Highly variable chloroplast markers for evaluating plant phylogeny at low taxonomic levels and for DNA barcoding. PLoS One (2012) 1.49
The unique HCV genotype distribution and the discovery of a novel subtype 6u among IDUs co-infected with HIV-1 in Yunnan, China. J Med Virol (2008) 1.49
Fluorescent cocaine probes: a tool for the selection and engineering of therapeutic antibodies. J Am Chem Soc (2005) 1.48
Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry (2006) 1.48
To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition. Biochim Biophys Acta (2009) 1.48
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. J Hypertens (2012) 1.47
A vaccine strategy that induces protective immunity against heroin. J Med Chem (2011) 1.47
An analysis of the accuracy of the CyberKnife: a robotic frameless stereotactic radiosurgical system. Neurosurgery (2003) 1.47
Zinc-binding groups modulate selective inhibition of MMPs. ChemMedChem (2008) 1.47
New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups. J Am Chem Soc (2004) 1.46
Vaccination against weight gain. Proc Natl Acad Sci U S A (2006) 1.45
The design of inhibitors for medicinally relevant metalloproteins. ChemMedChem (2007) 1.44
Association of mild to moderate kidney dysfunction with coronary artery calcification in patients with suspected coronary artery disease. Cardiology (2012) 1.44
Tongue engorgement with prolonged use of the esophageal-tracheal Combitube. Ann Emerg Med (2004) 1.43
Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A (2011) 1.43
Exploring origins: was John Bonica's model of modern-day pain management influenced by John Lundy's earlier work? Reg Anesth Pain Med (2007) 1.42
N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways. J Biol Chem (2006) 1.42
Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. J Am Coll Surg (2007) 1.41
Postsynthetic modification of metal-organic frameworks--a progress report. Chem Soc Rev (2010) 1.40
Immunopharmacotherapy: vaccination strategies as a treatment for drug abuse and dependence. Pharmacol Biochem Behav (2009) 1.39
MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacol Biochem Behav (2007) 1.39
Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations. Chem Commun (Camb) (2008) 1.37
Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem (2004) 1.37
Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery. Mol Pharm (2007) 1.35
Examination of novel zinc-binding groups for use in matrix metalloproteinase inhibitors. Inorg Chem (2003) 1.35
Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. Ann Thorac Surg (2003) 1.34
Histidine kinases as targets for new antimicrobial agents. Bioorg Med Chem (2002) 1.33
CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. J Neurosci (2010) 1.33
Impact of distinct chemical structures for the development of a methamphetamine vaccine. J Am Chem Soc (2011) 1.31
Synthesis and biological validation of a ubiquitous quorum-sensing molecule. Angew Chem Int Ed Engl (2004) 1.29
Hydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approach. Angew Chem Int Ed Engl (2010) 1.29
Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. J Neurosci (2007) 1.29
The Genome Database for Rosaceae (GDR): year 10 update. Nucleic Acids Res (2013) 1.28
Potent, selective pyrone-based inhibitors of stromelysin-1. J Am Chem Soc (2005) 1.28
Metal binding studies and EPR spectroscopy of the manganese transport regulator MntR. Biochemistry (2006) 1.28
Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress. Am J Physiol Endocrinol Metab (2010) 1.27
The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. ACS Chem Biol (2006) 1.26
The Contribution of DOPA to Substrate-Peptide Adhesion and Internal Cohesion of Mussel-Inspired Synthetic Peptide Films. Adv Funct Mater (2010) 1.26
A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol Pharm (2010) 1.26
Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc Natl Acad Sci U S A (2009) 1.26
Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model. Chem Commun (Camb) (2006) 1.25
Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation. PLoS Genet (2011) 1.24
Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A (2013) 1.24
Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J Clin Invest (2005) 1.24
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis. Proc Natl Acad Sci U S A (2004) 1.21
A credit-card library approach for disrupting protein-protein interactions. Bioorg Med Chem (2005) 1.20
Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose. Pharmacol Biochem Behav (2005) 1.19
Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors. Bioorg Med Chem Lett (2007) 1.19
A high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry. Biomed Chromatogr (2013) 1.19
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther (2011) 1.18
A bioinorganic perspective on matrix metalloproteinase inhibition. Curr Top Med Chem (2004) 1.18
A method for the generation of combinatorial antibody libraries using pIX phage display. Proc Natl Acad Sci U S A (2002) 1.18
The elastin network: its relationship with collagen and cells in articular cartilage as visualized by multiphoton microscopy. J Anat (2009) 1.17
Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity. J Biol Inorg Chem (2005) 1.17
Interspecies and interkingdom communication mediated by bacterial quorum sensing. Chem Soc Rev (2008) 1.17
MicroRNA-143 inhibits tumor growth and angiogenesis and sensitizes chemosensitivity to oxaliplatin in colorectal cancers. Cell Cycle (2013) 1.16
Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem (2010) 1.15
Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. J Am Chem Soc (2010) 1.14
An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. J Am Chem Soc (2008) 1.14
Aptamer selection by high-throughput sequencing and informatic analysis. Biotechniques (2011) 1.14
Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. Brain Res (2012) 1.13
A new role for old ligands: discerning chelators for zinc metalloproteinases. J Am Chem Soc (2006) 1.13
Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing. J Am Chem Soc (2006) 1.13