A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene.

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Published in J Biol Chem on March 13, 2013

Authors

Hui Wei1, Tapan K Bera, Alan S Wayne, Laiman Xiang, Simona Colantonio, Oleg Chertov, Ira Pastan

Author Affiliations

1: Laboratory of Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

Associated clinical trials:

CAT-8015 in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma | NCT00659425

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