A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP).

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMID 23490032)

Published in Int J Stroke on March 12, 2013

Authors

Götz Thomalla1, Jochen B Fiebach, Leif Østergaard, Salvador Pedraza, Vincent Thijs, Norbert Nighoghossian, Pascal Roy, Keith W Muir, Martin Ebinger, Bastian Cheng, Ivana Galinovic, Tae-Hee Cho, Josep Puig, Florent Boutitie, Claus Z Simonsen, Matthias Endres, Jens Fiehler, Christian Gerloff, WAKE-UP investigators

Author Affiliations

1: Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Articles citing this

Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev (2014) 1.76

Intraventricular hemorrhage expansion in patients with spontaneous intracerebral hemorrhage. Neurology (2015) 1.42

Mechanical Thrombectomy in Stroke. Dtsch Arztebl Int (2015) 1.33

Wake-up stroke and stroke of unknown onset: a critical review. Front Neurol (2014) 0.98

Prehospital stroke care: new prospects for treatment and clinical research. Neurology (2013) 0.92

Wake-up stroke: clinical characteristics, imaging findings, and treatment option - an update. Front Neurol (2014) 0.88

Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. Int J Stroke (2014) 0.86

THrombolysis for Acute Wake-up and unclear-onset Strokes with alteplase at 0·6 mg/kg (THAWS) Trial. Int J Stroke (2014) 0.84

Neuroimaging as a Selection Tool and Endpoint in Clinical and Pre-clinical Trials. Transl Stroke Res (2016) 0.80

Acute ischemic stroke imaging: a practical approach for diagnosis and triage. Int J Cardiovasc Imaging (2015) 0.78

Association between the perfusion/diffusion and diffusion/FLAIR mismatch: data from the AXIS2 trial. J Cereb Blood Flow Metab (2015) 0.78

What to do With Wake-Up Stroke. Neurohospitalist (2015) 0.78

IV thrombolysis for treatment of patients with stroke upon awakening: Yes? No? Neurol Clin Pract (2015) 0.77

Imaging-based management of acute ischemic stroke patients: current neuroradiological perspectives. Korean J Radiol (2015) 0.77

An update in sleep neurology: the latest bedtime stories. J Neurol (2014) 0.76

Association Between Time From Stroke Onset and Fluid-Attenuated Inversion Recovery Lesion Intensity Is Modified by Status of Collateral Circulation. Stroke (2016) 0.75

Evaluation of Cerebral Perfusion in Patients Undergoing Intravenous Recombinant Tissue Plasminogen Activator Thrombolysis. Neurol Med Chir (Tokyo) (2015) 0.75

Automated real-time text messaging as a means for rapidly identifying acute stroke patients for clinical trials. Trials (2014) 0.75

Modeling the Cost Effectiveness of Neuroimaging-Based Treatment of Acute Wake-Up Stroke. PLoS One (2016) 0.75

Wake-up Strokes Are Similar to Known-Onset Morning Strokes in Severity and Outcome. J Neurol Neurol Disord (2014) 0.75

Are the current MRI criteria using the DWI-FLAIR mismatch concept for selection of patients with wake-up stroke to thrombolysis excluding too many patients? Scand J Trauma Resusc Emerg Med (2015) 0.75

Emergency Neurological Life Support: Acute Ischemic Stroke. Neurocrit Care (2017) 0.75

Fully automated stroke tissue estimation using random forest classifiers (FASTER). J Cereb Blood Flow Metab (2016) 0.75

The challenge of basilar artery occlusion wake-up stroke: too late for intravenous thrombolysis? Neurol Sci (2016) 0.75

The Chinese Stroke Association scientific statement: intravenous thrombolysis in acute ischaemic stroke. Stroke Vasc Neurol (2017) 0.75

Articles by these authors

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2015) 7.99

Follicular lymphoma international prognostic index. Blood (2004) 7.20

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 6.71

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet (2015) 6.13

Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med (2014) 5.44

The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet (2011) 5.17

Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain (2005) 4.99

Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62

Improving the assessment of outcomes in stroke: use of a structured interview to assign grades on the modified Rankin Scale. Stroke (2002) 4.30

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet (2003) 4.19

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol (2008) 3.98

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93

Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol (2008) 3.91

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke (2009) 3.55

Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke (2006) 3.49

Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix. Magn Reson Med (2003) 3.44

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40

Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol (2009) 3.36

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol (2011) 3.18

Brain oscillatory substrates of visual short-term memory capacity. Curr Biol (2009) 3.15

Reliability of clinical guidelines in the detection of patients at risk following mild head injury: results of a prospective study. J Neurosurg (2004) 3.10

The influence of percutaneous atrial septal defect closure on the occurrence of migraine. Eur Heart J (2005) 3.06

Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol (2009) 2.99

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med (2012) 2.65

Prehospital thrombolysis in acute stroke: results of the PHANTOM-S pilot study. Neurology (2012) 2.60

Comparative overview of brain perfusion imaging techniques. Stroke (2005) 2.59

Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation (2003) 2.59

Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol (2002) 2.54

Neuroenhancement of the aging brain: restoring skill acquisition in old subjects. Ann Neurol (2012) 2.54

Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study. Lancet Neurol (2008) 2.53

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 2.50

The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain (2012) 2.49

Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1,290 patients. Cancer (2010) 2.46

MRI versus CT-based thrombolysis treatment within and beyond the 3 h time window after stroke onset: a cohort study. Lancet Neurol (2006) 2.42

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet (2013) 2.42

Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke (2013) 2.36

Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients. Stroke (2007) 2.36

Comparison of CT and CT angiography source images with diffusion-weighted imaging in patients with acute stroke within 6 hours after onset. Stroke (2002) 2.33

Comparison of perfusion computed tomography and computed tomography angiography source images with perfusion-weighted imaging and diffusion-weighted imaging in patients with acute stroke of less than 6 hours' duration. Stroke (2004) 2.24

Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits MMP-9-mediated blood-brain-barrier breakdown in a mouse model for ischemic stroke. Circ Res (2013) 2.21

Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res (2006) 2.21

Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds. Ann Neurol (2011) 2.15

Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (> or =80 years) stroke patients. Stroke (2005) 2.13

NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke (2007) 2.13

Smoking-thrombolysis paradox: recanalization and reperfusion rates after intravenous tissue plasminogen activator in smokers with ischemic stroke. Stroke (2013) 2.11

Peritoneal carcinomatosis from gastric cancer: a multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy. Ann Surg Oncol (2010) 2.10

How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke (2008) 2.09

Severe renal impairment is associated with symptomatic intracerebral hemorrhage after thrombolysis for ischemic stroke. Stroke (2013) 2.07

Perfusion-weighted imaging/diffusion-weighted imaging mismatch on MRI can now be used to select patients for recombinant tissue plasminogen activator beyond 3 hours: pro. Stroke (2005) 2.06

Fluid-attenuated inversion recovery evolution within 12 hours from stroke onset: a reliable tissue clock? Stroke (2009) 1.99

Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke (2005) 1.94

MRI monitoring of neuroinflammation in mouse focal ischemia. Stroke (2006) 1.91

Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart. Nat Med (2008) 1.91

Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke (2003) 1.90

Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra? Stroke (2003) 1.90

Randomized, controlled trial of insulin for acute poststroke hyperglycemia. Ann Neurol (2010) 1.90

Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology (2014) 1.85

Diffusion-weighted MR imaging in the acute phase of transient ischemic attacks. AJNR Am J Neuroradiol (2002) 1.83

Prediction of malignant middle cerebral artery infarction by early perfusion- and diffusion-weighted magnetic resonance imaging. Stroke (2003) 1.82

The role of multiple contralesional motor areas for complex hand movements after internal capsular lesion. J Neurosci (2006) 1.82

Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke. Stroke (2002) 1.78

What is the relevance of obtaining multiple blood samples for culture? A comprehensive model to optimize the strategy for diagnosing bacteremia. Clin Infect Dis (2002) 1.76

The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism. J Cereb Blood Flow Metab (2011) 1.76

Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis (2006) 1.75

Modeling dendrite density from magnetic resonance diffusion measurements. Neuroimage (2006) 1.74

Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke. Stroke (2004) 1.73

Can hospital discharge databases be used to follow ischemic stroke incidence? Stroke (2013) 1.73

Interstitial pneumonitis after oxaliplatin treatment in colorectal cancer. Clin Transl Oncol (2005) 1.72

Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging. Ann Neurol (2008) 1.71

Reliability of the modified Rankin Scale across multiple raters: benefits of a structured interview. Stroke (2005) 1.70

Vascular effects of diet supplementation with plant sterols. J Am Coll Cardiol (2008) 1.68

Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab (2010) 1.68

Acute stroke imaging research roadmap. Stroke (2008) 1.66

MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients. Stroke (2007) 1.66

Meta-analysis of continuous outcomes combining individual patient data and aggregate data. Stat Med (2008) 1.65

Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome? Stroke (2007) 1.65

Negative fluid-attenuated inversion recovery imaging identifies acute ischemic stroke at 3 hours or less. Ann Neurol (2009) 1.64

Patients with acute stroke treated with intravenous tPA 3-6 hours after stroke onset: correlations between MR angiography findings and perfusion- and diffusion-weighted imaging in the DEFUSE study. Radiology (2008) 1.64