Acute stroke imaging research roadmap.

Current status of endovascular stroke treatment. Circulation (2011) 2.42

CT perfusion mean transit time maps optimally distinguish benign oligemia from true "at-risk" ischemic penumbra, but thresholds vary by postprocessing technique. AJNR Am J Neuroradiol (2011) 1.68

Acute stroke magnetic resonance imaging: current status and future perspective. Neuroradiology (2009) 1.59

Acute Stroke Imaging Research Roadmap II. Stroke (2013) 1.47

CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform. Stroke (2011) 1.38

Accuracy and reliability assessment of CT and MR perfusion analysis software using a digital phantom. Radiology (2012) 1.11

Defining an Acidosis-Based Ischemic Penumbra from pH-Weighted MRI. Transl Stroke Res (2011) 1.11

Predicting language improvement in acute stroke patients presenting with aphasia: a multivariate logistic model using location-weighted atlas-based analysis of admission CT perfusion scans. AJNR Am J Neuroradiol (2010) 1.07

Combined spin- and gradient-echo perfusion-weighted imaging. Magn Reson Med (2011) 1.05

Wake-up stroke: clinical and neuroimaging characteristics. Cerebrovasc Dis (2010) 0.97

Automated versus manual post-processing of perfusion-CT data in patients with acute cerebral ischemia: influence on interobserver variability. Neuroradiology (2009) 0.97

Pretreatment blood-brain barrier damage and post-treatment intracranial hemorrhage in patients receiving intravenous tissue-type plasminogen activator. Stroke (2014) 0.94

The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg (2013) 0.90

Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients. PLoS One (2012) 0.90

MR perfusion imaging in acute ischemic stroke. Neuroimaging Clin N Am (2011) 0.89

CT perfusion in acute stroke: know the mimics, potential pitfalls, artifacts, and technical errors. Emerg Radiol (2013) 0.88

Susceptibility of Tmax to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms. J Cereb Blood Flow Metab (2010) 0.88

Advanced multimodal CT/MRI approaches to hyperacute stroke diagnosis, treatment, and monitoring. Ann N Y Acad Sci (2012) 0.88

Research and technology in neurocritical care. Neurocrit Care (2012) 0.86

Vessel size imaging reveals pathological changes of microvessel density and size in acute ischemia. J Cereb Blood Flow Metab (2011) 0.84

The vascular mean transit time: a surrogate for the penumbra flow threshold? J Cereb Blood Flow Metab (2010) 0.82

Clinical relevance and practical implications of trials of perfusion and angiographic imaging in patients with acute ischaemic stroke: a multicentre cohort imaging study. J Neurol Neurosurg Psychiatry (2013) 0.82

Multiparametric magnetic resonance imaging of brain disorders. Top Magn Reson Imaging (2010) 0.81

Effect of extended CT perfusion acquisition time on ischemic core and penumbra volume estimation in patients with acute ischemic stroke due to a large vessel occlusion. PLoS One (2015) 0.81

Perfusion-CT guided intravenous thrombolysis in patients with unknown-onset stroke: a randomized, double-blind, placebo-controlled, pilot feasibility trial. Neuroradiology (2011) 0.81

MRI of blood-brain barrier permeability in cerebral ischemia. Transl Stroke Res (2012) 0.80

Acute ischemic stroke treatment, part 1: patient selection "the 50% barrier and the capillary index score". Front Neurol (2015) 0.79

Is CT-Based Perfusion and Collateral Imaging Sensitive to Time Since Stroke Onset? Front Neurol (2015) 0.79

Pharmacological and non-pharmacological recanalization strategies in acute ischemic stroke. Front Neurol (2011) 0.77

Radiation dose evaluation in multidetector-row CT imaging for acute stroke with an anthropomorphic phantom. Br J Radiol (2010) 0.77

Wake-up (or wake-up for) stroke: a treatable stroke. Neuroradiol J (2013) 0.76

Comparison of partial volume effects in arterial and venous contrast curves in CT brain perfusion imaging. PLoS One (2014) 0.75

Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes. Stroke (2016) 0.75

Management of Acute Hypertensive Response in Patients With Ischemic Stroke. Neurohospitalist (2016) 0.75

Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling. Stroke (2016) 0.75

Mobile platform for treatment of stroke: A case study of tele-assistance. Health Informatics J (2015) 0.75

Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia. J Vis Exp (2017) 0.75

Severe cerebral hypovolemia on perfusion CT and lower body weight are associated with parenchymal haemorrhage after thrombolysis. Neuroradiology (2016) 0.75

Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med (2011) 28.99

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med (2008) 28.42

Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med (2006) 18.25

Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med (2013) 14.78

A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63

Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2013) 14.49

Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med (2011) 12.76

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet (2010) 12.21

Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med (2015) 12.06

Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet (2007) 10.74

Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke (2010) 10.66

Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol (2006) 10.51

A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97

Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med (2015) 9.58

Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med (2005) 9.58

Stroke. Lancet (2008) 9.51

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol (2008) 9.02

Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet (2007) 8.68

Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke (2008) 8.45

Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med (2012) 8.19

Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke (2005) 8.05

Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature (2007) 8.03

Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet (2012) 7.89

Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke (2003) 7.75

Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 7.48

Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med (2008) 7.25

1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23

National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke (2006) 6.94

Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain (2005) 6.81

Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science (2007) 6.75

Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke (2009) 6.62

Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol (2007) 6.15

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med (2008) 6.08

Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol (2009) 6.02

MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol (2012) 5.91

Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke. N Engl J Med (2014) 5.79

Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med (2008) 5.77

2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke (2015) 5.64

Behavioral equipoise: a way to resolve ethical stalemates in clinical research. Am J Bioeth (2011) 5.26

Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition. Stroke (2005) 5.18

European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace (2013) 5.16

Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association. Stroke (2012) 5.13

The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison. Lancet (2007) 4.99

Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA (2004) 4.82

Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ (2010) 4.74

Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. JAMA (2011) 4.46

The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke (2004) 4.39

Pooling of animal experimental data reveals influence of study design and publication bias. Stroke (2004) 4.37

Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet (2008) 4.14

Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts. Circulation (2012) 4.10

White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study. Cereb Cortex (2005) 4.07

Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest (2008) 4.01

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol (2008) 3.98

Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch Gen Psychiatry (2005) 3.94

Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol (2008) 3.91

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 3.87

A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med (2012) 3.81

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

NXY-059 for the treatment of acute ischemic stroke. N Engl J Med (2007) 3.70

Carotid artery stenosis: gray-scale and Doppler US diagnosis--Society of Radiologists in Ultrasound Consensus Conference. Radiology (2003) 3.59

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol (2003) 3.58

Statistical analysis of the primary outcome in acute stroke trials. Stroke (2012) 3.52

Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial. Stroke (2010) 3.43

National US estimates of recombinant tissue plasminogen activator use: ICD-9 codes substantially underestimate. Stroke (2008) 3.40

Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment. Neuroreport (2002) 3.31

Good laboratory practice: preventing introduction of bias at the bench. Stroke (2008) 3.27

Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke (2008) 3.21

Very early administration of progesterone for acute traumatic brain injury. N Engl J Med (2014) 3.20

Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab (2005) 3.20

Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med (2002) 3.18

DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4·5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol (2011) 3.18

Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest (2004) 3.11